发明申请
US20090099157A1 TETRAHYDRO-PYRAZOLO-PYRIDINE THIOETHER MODULATORS OF CATHEPSIN S
审中-公开
四氢吡喃类吡嗪类三氯乙烯调节剂
- 专利标题： TETRAHYDRO-PYRAZOLO-PYRIDINE THIOETHER MODULATORS OF CATHEPSIN S
- 专利标题（中）： 四氢吡喃类吡嗪类三氯乙烯调节剂
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申请号： US12031551申请日： 2008-02-14
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公开(公告)号： US20090099157A1公开(公告)日： 2009-04-16
- 发明人: Michael K. Ameriks , Kristen L. Arienti , James P. Edwards , Cheryl A. Grice , Todd K. Jones , Alice Lee-Dutra , Jing Liu , Neelakandha S. Mani , Danielle K. Neff , Alvah T. Wickboldt , John J.M. Wiener
- 申请人： Michael K. Ameriks , Kristen L. Arienti , James P. Edwards , Cheryl A. Grice , Todd K. Jones , Alice Lee-Dutra , Jing Liu , Neelakandha S. Mani , Danielle K. Neff , Alvah T. Wickboldt , John J.M. Wiener
- 主分类号： A61K31/551
- IPC分类号： A61K31/551 ; C07D471/04 ; A61K31/5377 ; A61P9/10 ; A61P37/08 ; A61K31/437
摘要：
Tetrahydro-pyrazolo-pyridine thioether compounds are described, which are useful as cathepsin S modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by cathepsin S activity, such as psoriasis, pain, multiple sclerosis, atherosclerosis, and rheumatoid arthritis.