-
公开(公告)号：US20090099157A1
公开(公告)日：2009-04-16
申请号：US12031551
申请日：2008-02-14
申请人： Michael K. Ameriks , Kristen L. Arienti , James P. Edwards , Cheryl A. Grice , Todd K. Jones , Alice Lee-Dutra , Jing Liu , Neelakandha S. Mani , Danielle K. Neff , Alvah T. Wickboldt , John J.M. Wiener
发明人： Michael K. Ameriks , Kristen L. Arienti , James P. Edwards , Cheryl A. Grice , Todd K. Jones , Alice Lee-Dutra , Jing Liu , Neelakandha S. Mani , Danielle K. Neff , Alvah T. Wickboldt , John J.M. Wiener
IPC分类号： A61K31/551 , C07D471/04 , A61K31/5377 , A61P9/10 , A61P37/08 , A61K31/437
CPC分类号： C07D471/04
摘要： Tetrahydro-pyrazolo-pyridine thioether compounds are described, which are useful as cathepsin S modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by cathepsin S activity, such as psoriasis, pain, multiple sclerosis, atherosclerosis, and rheumatoid arthritis.
摘要翻译： 描述了四氢吡唑并吡啶硫醚化合物，其可用作组织蛋白酶S调节剂。 这些化合物可用于治疗由组织蛋白酶S活性介导的疾病状态，病症和病症的药物组合物和方法，例如银屑病，疼痛，多发性硬化，动脉粥样硬化和类风湿性关节炎。
-
公开(公告)号：US20110218338A1
公开(公告)日：2011-09-08
申请号：US13084226
申请日：2011-04-11
申请人： Hui Cai , Frank Chavez , James P. Edwards , Anne E. Fitzgerald , Jing Liu , Neelakandha S. Mani , Danielle K. Neff , Michele C. Rizzolio , Brad M. Savall , Deborah M. Smith , Jennifer D. Venable , Jianmei Wei , Ronald L. Wolin
发明人： Hui Cai , Frank Chavez , James P. Edwards , Anne E. Fitzgerald , Jing Liu , Neelakandha S. Mani , Danielle K. Neff , Michele C. Rizzolio , Brad M. Savall , Deborah M. Smith , Jennifer D. Venable , Jianmei Wei , Ronald L. Wolin
IPC分类号： C07D403/14 , C07D403/04 , C07D413/14 , C07D405/14
CPC分类号： C07D498/04 , C07D239/48 , C07D239/70 , C07D239/95 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/14 , C07D471/04 , C07D487/04 , C07D487/08 , C07D487/10 , C07D519/00
摘要： 2-Aminopyrimidine compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritus.
摘要翻译： 描述了2-氨基嘧啶化合物，其可用作H 4受体调节剂。 这些化合物可用于治疗由H 4受体活性介导的疾病状态，病症和病症的药物组合物和方法，例如过敏，哮喘，自身免疫性疾病和瘙痒症。
-
公开(公告)号：US20080194577A1
公开(公告)日：2008-08-14
申请号：US12070051
申请日：2008-02-14
申请人： Hui Cai , Frank Chavez , James P. Edwards , Anne E. Fitzgerald , Jing Liu , Neelakandha S. Mani , Danielle K. Neff , Michele C. Rizzolio , Brad M. Savall , Deborah M. Smith , Jennifer D. Venable , Jianmei Wei , Ronald L. Wolin
发明人： Hui Cai , Frank Chavez , James P. Edwards , Anne E. Fitzgerald , Jing Liu , Neelakandha S. Mani , Danielle K. Neff , Michele C. Rizzolio , Brad M. Savall , Deborah M. Smith , Jennifer D. Venable , Jianmei Wei , Ronald L. Wolin
IPC分类号： A61K31/496 , C07D239/48 , A61K31/505 , A61P37/08 , C07K14/705 , A61P17/00 , A61P29/00 , C07D403/04
CPC分类号： C07D498/04 , C07D239/48 , C07D239/70 , C07D239/95 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/14 , C07D471/04 , C07D487/04 , C07D487/08 , C07D487/10 , C07D519/00
摘要： 2-Aminopyrimidine compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritis.
摘要翻译： 描述了2-氨基嘧啶化合物，其可用作H 4 S 5受体调节剂。 这样的化合物可以用于治疗由H 4 S受体活性介导的疾病状态，病症和病症的药物组合物和方法，例如过敏，哮喘，自身免疫疾病和瘙痒症。
-
公开(公告)号：US20110160452A1
公开(公告)日：2011-06-30
申请号：US13043420
申请日：2011-03-08
申请人： Hui Cai , Frank Chavez , James P. Edwards , Anne E. Fitzgerald , Jing Liu , Neelakandha S. Mani , Danielle K. Neff , Michele C. Rizzolio , Brad M. Savall , Deborah M. Smith , Jennifer D. Venable , Jianmai Wei , Ronald L. Wolin
发明人： Hui Cai , Frank Chavez , James P. Edwards , Anne E. Fitzgerald , Jing Liu , Neelakandha S. Mani , Danielle K. Neff , Michele C. Rizzolio , Brad M. Savall , Deborah M. Smith , Jennifer D. Venable , Jianmai Wei , Ronald L. Wolin
IPC分类号： C07D403/04 , C07D401/04 , C07D403/14 , C07D498/04
CPC分类号： C07D498/04 , C07D239/48 , C07D239/70 , C07D239/95 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/14 , C07D471/04 , C07D487/04 , C07D487/08 , C07D487/10 , C07D519/00
摘要： 2-Aminopyrimidine compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritis.
-
公开(公告)号：US07250427B2
公开(公告)日：2007-07-31
申请号：US11168107
申请日：2005-06-27
IPC分类号： A61K31/4184 , C07D235/12
CPC分类号： C07D403/12 , C07D235/18 , C07D401/12
摘要： Aryl substituted benzimidazole and imidazo[4,5]pyridine ethers are described as inhibitors of Cds1 and useful as adjuvants to chemotherapy or radiation therapy in the treatment of cancer.
摘要翻译： 芳基取代的苯并咪唑和咪唑并[4,5]吡啶醚被描述为Cds1的抑制剂，可用作治疗癌症的化学疗法或放射治疗的佐剂。
-
公开(公告)号：US08937075B2
公开(公告)日：2015-01-20
申请号：US13456165
申请日：2012-04-25
IPC分类号： A01N43/90 , A61K31/519 , C07D491/00 , C07D495/00 , C07D495/04 , C07D493/04 , C07D519/00
CPC分类号： C07D495/04 , C07D493/04 , C07D519/00
摘要： Thieno- and furo-pyrimidine compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the modulation of histamine H4 receptor activity and for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as inflammation.
-
公开(公告)号：US08927555B2
公开(公告)日：2015-01-06
申请号：US13456180
申请日：2012-04-25
IPC分类号： A01N43/90 , A61K31/519 , C07D491/00 , C07D495/00 , C07D495/04 , C07D493/04 , C07D519/00
CPC分类号： C07D495/04 , C07D493/04 , C07D519/00
摘要： Thieno- and furo-pyrimidine compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the modulation of histamine H4 receptor activity and for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as inflammation.
摘要翻译： 描述了噻吩和呋喃嘧啶化合物，其可用作H 4受体调节剂。 这些化合物可用于调节组胺H 4受体活性的药物组合物和方法，以及用于治疗由H 4受体活性如炎症介导的疾病状态，病症和病况。
-
8.发明申请THIENO- ADN FURO-PYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR 审中-公开组胺H4受体的THIENO-ADN FURO-PYRIMIDINE调节剂公开(公告)号：US20120214792A1
公开(公告)日：2012-08-23
申请号：US13456180
申请日：2012-04-25
IPC分类号： A61K31/519 , C07D491/048 , C07D243/08 , A61K31/551 , A61P37/08 , A61P11/06 , A61P27/02 , A61P11/00 , A61P9/10 , A61P19/02 , A61P1/00 , A61P1/04 , A61P17/06 , A61P17/00 , A61P37/06 , A61P7/06 , C07D495/04
CPC分类号： C07D495/04 , C07D493/04 , C07D519/00
摘要： Thieno- and furo-pyrimidine compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the modulation of histamine H4 receptor activity and for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as inflammation.
摘要翻译： 描述了噻吩和呋喃嘧啶化合物，其可用作H 4受体调节剂。 这些化合物可用于调节组胺H 4受体活性的药物组合物和方法，以及用于治疗由H 4受体活性如炎症介导的疾病状态，病症和病况。
-
公开(公告)号：US08440654B2
公开(公告)日：2013-05-14
申请号：US13456148
申请日：2012-04-25
IPC分类号： C07D491/04 , C07D243/08 , A61K31/519 , A61K31/5513 , A61K31/5025 , A61K31/501 , A61P29/00
CPC分类号： C07D495/04 , C07D493/04 , C07D519/00
摘要： Thieno- and furo-pyrimidine compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the modulation of histamine H4 receptor activity and for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as inflammation.
-
公开(公告)号：US20120208793A1
公开(公告)日：2012-08-16
申请号：US13456165
申请日：2012-04-25
IPC分类号： A61K31/497 , A61K31/4995 , A61K31/519 , C07D491/048 , C07D495/04 , A61K31/4985 , A61P29/00 , A61P37/08 , A61P17/00 , A61P11/06 , A61P27/04 , A61P11/00 , A61P9/10 , A61P19/02 , A61P25/00 , A61P1/00 , A61P17/06 , A61P27/02 , A61P3/10 , A61P7/06 , A61K31/5513
CPC分类号： C07D495/04 , C07D493/04 , C07D519/00
摘要： Thieno- and furo-pyrimidine compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the modulation of histamine H4 receptor activity and for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as inflammation.
-
-
-
-
-
-
-
-
-
搜索结果
14 条记录 (耗时 0.054 秒)
