公开(公告)号：US20090099157A1

公开(公告)日：2009-04-16

申请号：US12031551

申请日：2008-02-14

Applicant: Michael K. Ameriks ,  Kristen L. Arienti ,  James P. Edwards ,  Cheryl A. Grice ,  Todd K. Jones ,  Alice Lee-Dutra ,  Jing Liu ,  Neelakandha S. Mani ,  Danielle K. Neff ,  Alvah T. Wickboldt ,  John J.M. Wiener

Inventor： Michael K. Ameriks ,  Kristen L. Arienti ,  James P. Edwards ,  Cheryl A. Grice ,  Todd K. Jones ,  Alice Lee-Dutra ,  Jing Liu ,  Neelakandha S. Mani ,  Danielle K. Neff ,  Alvah T. Wickboldt ,  John J.M. Wiener

IPC: A61K31/551 ,  C07D471/04 ,  A61K31/5377 ,  A61P9/10 ,  A61P37/08 ,  A61K31/437

CPC classification number: C07D471/04

Abstract: Tetrahydro-pyrazolo-pyridine thioether compounds are described, which are useful as cathepsin S modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by cathepsin S activity, such as psoriasis, pain, multiple sclerosis, atherosclerosis, and rheumatoid arthritis.

Abstract translation: 描述了四氢吡唑并吡啶硫醚化合物，其可用作组织蛋白酶S调节剂。 这些化合物可用于治疗由组织蛋白酶S活性介导的疾病状态，病症和病症的药物组合物和方法，例如银屑病，疼痛，多发性硬化，动脉粥样硬化和类风湿性关节炎。

公开(公告)号：US20160039790A1

公开(公告)日：2016-02-11

申请号：US14777492

申请日：2014-03-13

Applicant: Wenying CHAI ,  Curt A. DVORAK ,  Wendy ECCLES ,  James P. EDWARDS ,  Steven D. GOLDBERG ,  Paul J. KRAWCZUK ,  Alec D. LEBSACK ,  Jing LIU ,  Daniel J. PIPPEL ,  Zachary S. SALES ,  Virginia M. TANIS ,  Mark S. TICHENOR ,  John J.M. WIENER ,  JANSSEN PHARMACEUTICA NV

Inventor： Wenying Chai ,  Curt A. Dvorak ,  Wendy Eccles ,  James P. Edwards ,  Steven D. Goldberg ,  Paul J. Krawczuk ,  Alec D. Lebsack ,  Jing Liu ,  Daniel J. Pippel ,  Zachary S. Sales ,  Virginia M. Tanis ,  Mark S. Tichenor ,  John J. M. Wiener

IPC: C07D401/12 ,  C07D401/14 ,  C07D403/14 ,  C07D403/12

CPC classification number: C07D401/12 ,  A61K31/4184 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/506 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14

Abstract: The present invention relates to compounds of Formula (I), and solvates, hydrates, and pharmaceutically acceptable salts thereof, wherein X1, X1′, X1″, R1, R2 and R3 are as defined herein, useful as FLAP modulators. The invention also relates to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention.

公开(公告)号：US20100280240A1

公开(公告)日：2010-11-04

申请号：US12833621

申请日：2010-07-09

Applicant: Brett D. Allison ,  Laurent Gomez ,  Cheryl A. Grice ,  Michael D. Hack ,  Brain J. Morrow ,  S. Timothy Motley ,  Alejandro Santillan, JR. ,  Karen J. Shaw ,  Kimberly L. Schwarz ,  Liu Y. Tang ,  Hariharan Venkatesan ,  John J.M. Wiener

Inventor： Brett D. Allison ,  Laurent Gomez ,  Cheryl A. Grice ,  Michael D. Hack ,  Brain J. Morrow ,  S. Timothy Motley ,  Alejandro Santillan, JR. ,  Karen J. Shaw ,  Kimberly L. Schwarz ,  Liu Y. Tang ,  Hariharan Venkatesan ,  John J.M. Wiener

IPC: C07D487/04 ,  C07D471/04 ,  C07D417/14 ,  C07D403/14 ,  C07D498/04

CPC classification number: A61K31/4375 ,  A61K31/444 ,  A61K31/4453 ,  A61K31/4709 ,  A61K31/498 ,  A61K31/538 ,  A61K31/5383 ,  A61K31/5415 ,  A61K31/55 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04

Abstract: Antibacterial compounds, compositions containing them, and methods of use for the inhibition of bacterial activity and the treatment, prevention or inhibition of bacterial infection.

Abstract translation: 抗菌化合物，含有它们的组合物，以及用于抑制细菌活性和治疗，预防或抑制细菌感染的方法。

公开(公告)号：US20100274004A1

公开(公告)日：2010-10-28

申请号：US12833682

申请日：2010-07-09

Applicant: Brett D. Allison ,  Laurent Gomez ,  Cheryl A. Grice ,  Michael D. Hack ,  Brian J. Morrow ,  S. Timothy Motley ,  Alejandro Santillan, JR. ,  Karen J. Shaw ,  Kimberly L. Schwarz ,  Liu Y. Tang ,  Hariharan Venkatesan ,  John J.M. Wiener

Inventor： Brett D. Allison ,  Laurent Gomez ,  Cheryl A. Grice ,  Michael D. Hack ,  Brian J. Morrow ,  S. Timothy Motley ,  Alejandro Santillan, JR. ,  Karen J. Shaw ,  Kimberly L. Schwarz ,  Liu Y. Tang ,  Hariharan Venkatesan ,  John J.M. Wiener

IPC: C07D487/04 ,  C07D471/04 ,  C07D417/14 ,  C07D403/14 ,  C07D498/04

CPC classification number: A61K31/4375 ,  A61K31/444 ,  A61K31/4453 ,  A61K31/4709 ,  A61K31/498 ,  A61K31/538 ,  A61K31/5383 ,  A61K31/5415 ,  A61K31/55 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04

Abstract: Antibacterial compounds, compositions containing them, and methods of use for the inhibition of bacterial activity and the treatment, prevention or inhibition of bacterial infection.

Abstract translation: 抗菌化合物，含有它们的组合物，以及用于抑制细菌活性和治疗，预防或抑制细菌感染的方法。