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公开(公告)号：US20090099157A1
公开(公告)日：2009-04-16
申请号：US12031551
申请日：2008-02-14
申请人： Michael K. Ameriks , Kristen L. Arienti , James P. Edwards , Cheryl A. Grice , Todd K. Jones , Alice Lee-Dutra , Jing Liu , Neelakandha S. Mani , Danielle K. Neff , Alvah T. Wickboldt , John J.M. Wiener
发明人： Michael K. Ameriks , Kristen L. Arienti , James P. Edwards , Cheryl A. Grice , Todd K. Jones , Alice Lee-Dutra , Jing Liu , Neelakandha S. Mani , Danielle K. Neff , Alvah T. Wickboldt , John J.M. Wiener
IPC分类号： A61K31/551 , C07D471/04 , A61K31/5377 , A61P9/10 , A61P37/08 , A61K31/437
CPC分类号： C07D471/04
摘要： Tetrahydro-pyrazolo-pyridine thioether compounds are described, which are useful as cathepsin S modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by cathepsin S activity, such as psoriasis, pain, multiple sclerosis, atherosclerosis, and rheumatoid arthritis.
摘要翻译： 描述了四氢吡唑并吡啶硫醚化合物，其可用作组织蛋白酶S调节剂。 这些化合物可用于治疗由组织蛋白酶S活性介导的疾病状态，病症和病症的药物组合物和方法，例如银屑病，疼痛，多发性硬化，动脉粥样硬化和类风湿性关节炎。
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公开(公告)号：US20080194577A1
公开(公告)日：2008-08-14
申请号：US12070051
申请日：2008-02-14
申请人： Hui Cai , Frank Chavez , James P. Edwards , Anne E. Fitzgerald , Jing Liu , Neelakandha S. Mani , Danielle K. Neff , Michele C. Rizzolio , Brad M. Savall , Deborah M. Smith , Jennifer D. Venable , Jianmei Wei , Ronald L. Wolin
发明人： Hui Cai , Frank Chavez , James P. Edwards , Anne E. Fitzgerald , Jing Liu , Neelakandha S. Mani , Danielle K. Neff , Michele C. Rizzolio , Brad M. Savall , Deborah M. Smith , Jennifer D. Venable , Jianmei Wei , Ronald L. Wolin
IPC分类号： A61K31/496 , C07D239/48 , A61K31/505 , A61P37/08 , C07K14/705 , A61P17/00 , A61P29/00 , C07D403/04
CPC分类号： C07D498/04 , C07D239/48 , C07D239/70 , C07D239/95 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/14 , C07D471/04 , C07D487/04 , C07D487/08 , C07D487/10 , C07D519/00
摘要： 2-Aminopyrimidine compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritis.
摘要翻译： 描述了2-氨基嘧啶化合物，其可用作H 4 S 5受体调节剂。 这样的化合物可以用于治疗由H 4 S受体活性介导的疾病状态，病症和病症的药物组合物和方法，例如过敏，哮喘，自身免疫疾病和瘙痒症。
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公开(公告)号：US20110218338A1
公开(公告)日：2011-09-08
申请号：US13084226
申请日：2011-04-11
申请人： Hui Cai , Frank Chavez , James P. Edwards , Anne E. Fitzgerald , Jing Liu , Neelakandha S. Mani , Danielle K. Neff , Michele C. Rizzolio , Brad M. Savall , Deborah M. Smith , Jennifer D. Venable , Jianmei Wei , Ronald L. Wolin
发明人： Hui Cai , Frank Chavez , James P. Edwards , Anne E. Fitzgerald , Jing Liu , Neelakandha S. Mani , Danielle K. Neff , Michele C. Rizzolio , Brad M. Savall , Deborah M. Smith , Jennifer D. Venable , Jianmei Wei , Ronald L. Wolin
IPC分类号： C07D403/14 , C07D403/04 , C07D413/14 , C07D405/14
CPC分类号： C07D498/04 , C07D239/48 , C07D239/70 , C07D239/95 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/14 , C07D471/04 , C07D487/04 , C07D487/08 , C07D487/10 , C07D519/00
摘要： 2-Aminopyrimidine compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritus.
摘要翻译： 描述了2-氨基嘧啶化合物，其可用作H 4受体调节剂。 这些化合物可用于治疗由H 4受体活性介导的疾病状态，病症和病症的药物组合物和方法，例如过敏，哮喘，自身免疫性疾病和瘙痒症。
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4.发明授权Benzofuro- and benzothienopyrimidine modulators of the histamine H4 receptor 有权组胺H4受体的苯并呋喃和苯并噻吩并嘧啶调节剂公开(公告)号：US07576092B2
公开(公告)日：2009-08-18
申请号：US11827354
申请日：2007-07-10
申请人： Frank Chavez , Michael P. Curtis , James P. Edwards , Anne E. Fitzgerald , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Jing Liu , Neelakandha S. Mani , Brad M. Savall
发明人： Frank Chavez , Michael P. Curtis , James P. Edwards , Anne E. Fitzgerald , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Jing Liu , Neelakandha S. Mani , Brad M. Savall
IPC分类号： A01N43/54 , A61K31/505 , C07D239/00 , C07D471/00 , C07D487/00 , C07D491/00
CPC分类号： C07D491/048 , C07D491/147 , C07D495/04 , C07D519/00
摘要： Benzofuro- and benzothienopyrimidine compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritis.
摘要翻译： 描述了苯并呋喃和苯并噻吩并嘧啶化合物，其可用作H 4受体调节剂。 这些化合物可用于治疗由H 4受体活性介导的疾病状态，病症和病症的药物组合物和方法，例如过敏，哮喘，自身免疫性疾病和瘙痒症。
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公开(公告)号：US20110160452A1
公开(公告)日：2011-06-30
申请号：US13043420
申请日：2011-03-08
申请人： Hui Cai , Frank Chavez , James P. Edwards , Anne E. Fitzgerald , Jing Liu , Neelakandha S. Mani , Danielle K. Neff , Michele C. Rizzolio , Brad M. Savall , Deborah M. Smith , Jennifer D. Venable , Jianmai Wei , Ronald L. Wolin
发明人： Hui Cai , Frank Chavez , James P. Edwards , Anne E. Fitzgerald , Jing Liu , Neelakandha S. Mani , Danielle K. Neff , Michele C. Rizzolio , Brad M. Savall , Deborah M. Smith , Jennifer D. Venable , Jianmai Wei , Ronald L. Wolin
IPC分类号： C07D403/04 , C07D401/04 , C07D403/14 , C07D498/04
CPC分类号： C07D498/04 , C07D239/48 , C07D239/70 , C07D239/95 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/14 , C07D471/04 , C07D487/04 , C07D487/08 , C07D487/10 , C07D519/00
摘要： 2-Aminopyrimidine compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritis.
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公开(公告)号：US20160039790A1
公开(公告)日：2016-02-11
申请号：US14777492
申请日：2014-03-13
申请人： Wenying CHAI , Curt A. DVORAK , Wendy ECCLES , James P. EDWARDS , Steven D. GOLDBERG , Paul J. KRAWCZUK , Alec D. LEBSACK , Jing LIU , Daniel J. PIPPEL , Zachary S. SALES , Virginia M. TANIS , Mark S. TICHENOR , John J.M. WIENER , JANSSEN PHARMACEUTICA NV
发明人： Wenying Chai , Curt A. Dvorak , Wendy Eccles , James P. Edwards , Steven D. Goldberg , Paul J. Krawczuk , Alec D. Lebsack , Jing Liu , Daniel J. Pippel , Zachary S. Sales , Virginia M. Tanis , Mark S. Tichenor , John J. M. Wiener
IPC分类号： C07D401/12 , C07D401/14 , C07D403/14 , C07D403/12
CPC分类号： C07D401/12 , A61K31/4184 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/506 , C07D401/14 , C07D403/12 , C07D403/14
摘要： The present invention relates to compounds of Formula (I), and solvates, hydrates, and pharmaceutically acceptable salts thereof, wherein X1, X1′, X1″, R1, R2 and R3 are as defined herein, useful as FLAP modulators. The invention also relates to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention.
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公开(公告)号：US20090076268A1
公开(公告)日：2009-03-19
申请号：US12283604
申请日：2008-09-12
IPC分类号： C07D491/048 , C07D307/91
CPC分类号： C07D491/04 , C07D307/91
摘要： This invention concerns the synthesis of polycyclic structural components of pharmacological compounds, including the synthesis of fused benzofuro-heterocycles, through selective palladium-catalyzed cross-coupling and intramolecular cyclization.
摘要翻译： 本发明涉及通过选择性钯催化的交叉偶联和分子内环化来合成药物化合物的多环结构组分，包括合成稠合的苯并呋喃 - 杂环。
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公开(公告)号：US20160046600A1
公开(公告)日：2016-02-18
申请号：US14777481
申请日：2014-03-13
申请人： Wenying CHAI , Charlotte DECKHUT , Curt A. DVORAK , Wendy ECCLES , James P. EDWARDS , Steven D. GOLDBERG , Paul J. KRAWCZUK , Alec D. LEBSACK , Jing LIU , Virginia M. TANIS , Kyle T. TARANTINO , JANSSEN PHARMACEUTICA NV
发明人： Wenying Chai , Charlotte Deckhut , Curt A. Dvorak , Wendy Eccles , James P. Edwards , Steven D. Goldberg , Paul J. Krawczuk , Alec D. Lebsack , Jing Liu , Virginia M. Tanis , Kyle T. Tarantino
IPC分类号： C07D401/12 , C07D405/14 , C07D417/12 , C07D417/14 , C07D413/14 , C07D401/14
CPC分类号： C07D417/14 , A61K31/428 , A61K31/4709 , A61K31/4725 , A61K31/506 , A61K31/5377 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/12
摘要： The present invention relates to compounds of Formula (I), and solvates, hydrates, and pharmaceutically acceptable salts thereof, wherein ring A, R1, R5 and R6 are as defined herein, useful as FLAP modulators. The invention also relates to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention.
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公开(公告)号：US10992555B2
公开(公告)日：2021-04-27
申请号：US12791704
申请日：2010-06-01
申请人： Kishor Kakatkar , Roy Nakashima , Rosanna Lee , Jing Liu , Derek Sanders , Rangaswamy Jagannathan , David Messina
发明人： Kishor Kakatkar , Roy Nakashima , Rosanna Lee , Jing Liu , Derek Sanders , Rangaswamy Jagannathan , David Messina
摘要： Network monitoring views can be recorded, replayed and shared. A monitoring system receives monitoring data, in response to which a monitoring view can be constructed. The monitoring data is maintained in memory or mass storage. One or more monitoring views can later be constructed in response to user preferences, even if those users would not have known to select those particular preferences or construct those particular monitoring views at the time. The monitoring views constructed in response to that monitoring data can be presented to users in a simulation of the problem, as if it were occurring at that time. Users can send particular monitoring views to others, with both the effects that the monitoring view can be preserved as part of a trouble report, and the persons receiving the monitoring view can have useful insight into what problem the user has pointed to.
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公开(公告)号：US09607509B2
公开(公告)日：2017-03-28
申请号：US14681122
申请日：2015-04-08
申请人： Jing Liu , Junpeng Hu , Yinling Ni , Yongxun Li , Siyi Chen , Jun Liu
发明人： Jing Liu , Junpeng Hu , Yinling Ni , Yongxun Li , Siyi Chen , Jun Liu
CPC分类号： G08G1/0125 , G01S1/026 , G08G1/0116 , G08G1/0129 , G08G1/017 , G08G1/0175 , G08G1/144 , G08G1/147
摘要： A framework for identifying parking areas from vehicle trajectory data is described herein. Vehicle trajectory data collected from a sensor network having a plurality of sensor stations for detecting vehicles is provided. The vehicle trajectory data is pre-processed to generate a tracking table of vehicles and analyzed to determine an interstation parking area between first and second sensor stations of interest based on input parameters from a user.
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