发明申请
US20100040636A1 Manipulation of Regulatory T Cell and Dc Function By Targeting Neuritin Gene Using Antibodies, Agonists and Antagonists
审中-公开
通过使用抗体，激动剂和拮抗剂靶向神经元基因来操纵调节性T细胞和Dc功能
- 专利标题： Manipulation of Regulatory T Cell and Dc Function By Targeting Neuritin Gene Using Antibodies, Agonists and Antagonists
- 专利标题（中）： 通过使用抗体，激动剂和拮抗剂靶向神经元基因来操纵调节性T细胞和Dc功能
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申请号： US11991693申请日： 2006-09-11
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公开(公告)号： US20100040636A1公开(公告)日： 2010-02-18
- 发明人: Hong Yu , Drew Pardoll , Xiaoya Pan , Charles George Drake , Jonathan D. Powell , Ching-Tai Huang
- 申请人： Hong Yu , Drew Pardoll , Xiaoya Pan , Charles George Drake , Jonathan D. Powell , Ching-Tai Huang
- 申请人地址： US MD Baltimore
- 专利权人： The Johns Hopkins University
- 当前专利权人： The Johns Hopkins University
- 当前专利权人地址： US MD Baltimore
- 国际申请： PCT/US06/35324 WO 20060911
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; A61K35/12 ; A61K38/16 ; C07K16/00 ; A61P31/00 ; C07H21/00 ; A61P35/00 ; C12N15/63 ; A61P37/06 ; A01K67/027 ; C12Q1/02
摘要：
We demonstrate herein that neuritin controls the homeostasis of regulatory T cells in an antigen dependent manner. Based on this discovery, we describe herein the application of neuritin as a therapeutic agent to manipulate antigen specific regulatory T cells in various disease settings is described. Thus manipulation of Treg cells and DCs through neuritin can be used to enhance immunotherapy of autoimmune diseases, cancer and infectious diseases, as well as enhance lymphocyte engraftment in settings of donor lymphocyte infusion, bone marrow transplant, as well as other types of transplants, and adoptive transfer.
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