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1.发明申请Manipulation of Regulatory T Cell and Dc Function By Targeting Neuritin Gene Using Antibodies, Agonists and Antagonists 审中-公开通过使用抗体，激动剂和拮抗剂靶向神经元基因来操纵调节性T细胞和Dc功能公开(公告)号：US20100040636A1
公开(公告)日：2010-02-18
申请号：US11991693
申请日：2006-09-11
申请人： Hong Yu , Drew Pardoll , Xiaoya Pan , Charles George Drake , Jonathan D. Powell , Ching-Tai Huang
发明人： Hong Yu , Drew Pardoll , Xiaoya Pan , Charles George Drake , Jonathan D. Powell , Ching-Tai Huang
IPC分类号： A61K39/395 , A61K35/12 , A61K38/16 , C07K16/00 , A61P31/00 , C07H21/00 , A61P35/00 , C12N15/63 , A61P37/06 , A01K67/027 , C12Q1/02
CPC分类号： C07K14/475 , A01K67/0275 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2267/0325 , A61K38/00 , A61K48/00 , C07K16/22 , C07K2319/30 , C12N15/8509 , C12N2510/00 , C12N2830/008 , G01N33/505
摘要： We demonstrate herein that neuritin controls the homeostasis of regulatory T cells in an antigen dependent manner. Based on this discovery, we describe herein the application of neuritin as a therapeutic agent to manipulate antigen specific regulatory T cells in various disease settings is described. Thus manipulation of Treg cells and DCs through neuritin can be used to enhance immunotherapy of autoimmune diseases, cancer and infectious diseases, as well as enhance lymphocyte engraftment in settings of donor lymphocyte infusion, bone marrow transplant, as well as other types of transplants, and adoptive transfer.
摘要翻译： 我们在这里证明神经细胞以抗原依赖的方式控制调节性T细胞的体内平衡。 基于这一发现，我们在这里描述了神经元作为治疗剂在各种疾病设置中操作抗原特异性调节性T细胞的应用。 因此，通过神经氨酸处理Treg细胞和DC可用于增强自身免疫性疾病，癌症和感染性疾病的免疫治疗，以及在供体淋巴细胞输注，骨髓移植以及其他类型的移植环境中增强淋巴细胞移植，以及 收养转让。
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公开(公告)号：US20140205578A1
公开(公告)日：2014-07-24
申请号：US14126994
申请日：2012-06-15
申请人： Jonathan D. Powell , Bo Xiao , Paul Worley , Gregg M. Delgoffe , Adam Waickman
发明人： Jonathan D. Powell , Bo Xiao , Paul Worley , Gregg M. Delgoffe , Adam Waickman
IPC分类号： C12N9/64
CPC分类号： C12N9/6445 , A61K38/4853 , C12Q1/37 , C12Y304/21034 , C12Y304/21035 , G01N33/5023 , G01N2333/96455 , G01N2800/042
摘要： Described herein are methods for increasing insulin sensitivity and for treating Diabetes (Type I and Type II). Also described herein are methods for increasing the amount of brown fat in a subject and for treating metabolic disorders, including obesity.
摘要翻译： 本文描述了增加胰岛素敏感性和治疗糖尿病（I型和II型）的方法。 本文还描述了增加受试者中棕色脂肪的量和用于治疗包括肥胖症在内的代谢紊乱的方法。
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3.发明申请公开(公告)号：US20110027295A1
公开(公告)日：2011-02-03
申请号：US12676741
申请日：2008-09-08
CPC分类号： A61K31/53 , A61K38/177 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/40 , A61K2300/00
摘要： Described are uses of A2a adenosine receptor antagonists and agonists to provide long term modulation of immune responses. A2a receptor antagonists in particular are provided to enhance immune responses by reducing T-cell mediated tolerance to antigenic stimuli and agonists are provided to enhance effectiveness of immunosuppressive agents. The application provides methods of treatment and prevention based on the long term effects of the compounds on T cell responses.
摘要翻译： 描述了A2a腺苷受体拮抗剂和激动剂用于提供免疫应答的长期调节的用途。 提供A2a受体拮抗剂以通过降低T细胞介导的对抗原刺激的耐受性来增强免疫应答，并提供激动剂以增强免疫抑制剂的有效性。 该应用基于化合物对T细胞应答的长期作用提供了治疗和预防的方法。
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4.发明授权公开(公告)号：US09585957B2
公开(公告)日：2017-03-07
申请号：US12676741
申请日：2008-09-08
IPC分类号： A61K39/00 , A61P37/00 , A61P35/00 , A61K45/06 , A61K39/395
CPC分类号： A61K31/53 , A61K38/177 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/40 , A61K2300/00
摘要： Described are uses of A2a adenosine receptor antagonists and agonists to provide long term modulation of immune responses. A2a receptor antagonists in particular are provided to enhance immune responses by reducing T-cell mediated tolerance to antigenic stimuli and agonists are provided to enhance effectiveness of immunosuppressive agents. The application provides methods of treatment and prevention based on the long term effects of the compounds on T cell responses.
摘要翻译： 描述了A2a腺苷受体拮抗剂和激动剂用于提供免疫应答的长期调节的用途。 提供A2a受体拮抗剂以通过降低T细胞介导的对抗原刺激的耐受性来增强免疫应答，并提供激动剂以增强免疫抑制剂的有效性。 该应用基于化合物对T细胞应答的长期作用提供了治疗和预防的方法。
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