发明申请
US20100160280A1 AMINOPYRIDINE AND CARBOXYPYRIDINE COMPOUNDS AS PHOSPHODIESTERASE 10 INHIBITORS
有权
氨基吡啶和羧基吡啶化合物作为磷酸二酯酶10抑制剂
- 专利标题: AMINOPYRIDINE AND CARBOXYPYRIDINE COMPOUNDS AS PHOSPHODIESTERASE 10 INHIBITORS
- 专利标题(中): 氨基吡啶和羧基吡啶化合物作为磷酸二酯酶10抑制剂
-
申请号: US12639931申请日: 2009-12-16
-
公开(公告)号: US20100160280A1公开(公告)日: 2010-06-24
- 发明人: Jennifer R. Allen , Ning Chen , James R. Falsey , Michael Frohn , Paul Harrington , Essa Hu , Matthew R. Kaller , Roxanne Kunz , Stephanie J. Mercede , Thomas T. Nguyen , Alexander J. Pickrell , Andreas Reichelt , Shannon Rumfelt , Robert M. Rzasa , Kelvin Sham , Aaron C. Siegmund , Christopher M. Tegley , Guomin Yao
- 申请人: Jennifer R. Allen , Ning Chen , James R. Falsey , Michael Frohn , Paul Harrington , Essa Hu , Matthew R. Kaller , Roxanne Kunz , Stephanie J. Mercede , Thomas T. Nguyen , Alexander J. Pickrell , Andreas Reichelt , Shannon Rumfelt , Robert M. Rzasa , Kelvin Sham , Aaron C. Siegmund , Christopher M. Tegley , Guomin Yao
- 申请人地址: US CA Thousand Oaks
- 专利权人: AMGEN INC.
- 当前专利权人: AMGEN INC.
- 当前专利权人地址: US CA Thousand Oaks
- 主分类号: A61K31/397
- IPC分类号: A61K31/397 ; C07D213/22 ; A61K31/444 ; C07D213/62 ; C07D413/14 ; A61K31/5377 ; C07D401/02 ; A61K31/506 ; C07D403/14 ; A61K31/4545 ; A61K31/496 ; C07D267/10 ; A61K31/553 ; C07D243/08 ; A61K31/551 ; A61P25/00
摘要:
Pyridine and pyrimidine compounds: or a pharmaceutically acceptable salt thereof, wherein m, n, R1, R2, R3, R4, R5, R6, R7, X1, X2, X3, X4, X5, X6, X7, X8, and Y are as defined in the specification; or a pharmaceutically acceptable salt thereof, wherein ring A, m, n, y, R2, R3, R4, R5, R6, R7, R8, R9, X1, X2, and ring A are as defined in the specification; and or a pharmaceutically acceptable salt thereof, wherein m, n, y, R2, R3, R4, R5, R6, R7, R9, X1, X2, and ring A are as defined in the specification; compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.
公开/授权文献
信息查询