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16 条记录 (耗时 0.032 秒)

    Phthalazine compounds as p38 map kinase modulators and methods of use thereof
    1.
    发明授权
    Phthalazine compounds as p38 map kinase modulators and methods of use thereof 有权
    酞嗪化合物作为p38映射激酶调节剂及其使用方法

    公开(公告)号：US08497269B2

    公开(公告)日：2013-07-30

    申请号：US13123889

    申请日：2009-10-07

    申请人： Andrew Tasker ,  James R. Falsey ,  Robert M. Rzasa ,  Bradley J. Herberich ,  Dawei Zhang

    发明人： Andrew Tasker ,  James R. Falsey ,  Robert M. Rzasa ,  Bradley J. Herberich ,  Dawei Zhang

    IPC分类号： C07D487/04 ,  A61K31/50 ,  A01N43/58

    CPC分类号： C07D401/12 ,  C07D237/30 ,  C07D237/32 ,  C07D237/34 ,  C07D401/04 ,  C07D403/04 ,  C07D413/04

    摘要： The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I wherein A4, L, R1, R2, R3, R5 and m are as defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, uses of such compounds and compositions for treatment of p38 map kinase mediated diseases including rheumatoid arthritis, psoriasis, chronic obstructive pulmonary disease, ankylosing spondylitis, pain and other inflammatory disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I.

    摘要翻译： 本发明包括一类新的可用于预防和治疗蛋白激酶介导的疾病，包括炎症和相关病症的化合物。 该化合物具有通式I，其中A4，L，R1，R2，R3，R5和m如本文所定义。 本发明还包括药物组合物，其包含一种或多种式I化合物，用于治疗p38地图激酶介导的疾病包括类风湿性关节炎，牛皮癣，慢性阻塞性肺病，强直性脊柱炎，疼痛和其它炎症性疾病的化合物和组合物的用途，如 以及可用于制备式I化合物的中间体和方法。

    Vanilloid receptor ligands and their use in treatments
    2.
    发明授权
    Vanilloid receptor ligands and their use in treatments 失效
    香草素受体配体及其在治疗中的应用

    公开(公告)号：US07511044B2

    公开(公告)日：2009-03-31

    申请号：US11056568

    申请日：2005-02-11

    申请人： Hui-Ling Wang ,  Chenera Balan ,  Elizabeth M. Doherty ,  James R. Falsey ,  Vijay Keshav Gore ,  Jodie Katon ,  Mark H. Norman

    发明人： Hui-Ling Wang ,  Chenera Balan ,  Elizabeth M. Doherty ,  James R. Falsey ,  Vijay Keshav Gore ,  Jodie Katon ,  Mark H. Norman

    IPC分类号： C07D403/04 ,  A61K31/496

    CPC分类号： C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04

    摘要： Pyrimidine ethers and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

    摘要翻译： 嘧啶醚和含有它们的组合物，用于治疗急性，炎性和神经性疼痛，牙痛，一般头痛，偏头痛，丛集性头痛，混合血管和非血管性综合征，紧张性头痛，一般炎症，关节炎，风湿性疾病，骨关节炎 ，炎症性肠病，炎症性眼病，炎症性或不稳定性膀胱病，银屑病，皮肤炎症成分炎症，慢性炎性病症，炎性疼痛及相关的痛觉过敏和异常性疼痛，神经性疼痛及相关的痛觉过敏和异常性疼痛，糖尿病性神经病疼痛，灼痛，交感神经痛 维持疼痛，输血综合征，哮喘，上皮组织损伤或功能障碍，单纯疱疹，呼吸系统内脏运动紊乱，泌尿生殖道，胃肠道或血管区域，伤口，烧伤，过敏性皮肤反应，瘙痒，白癜风，一般胃肠道疾病，胃溃疡， 杜 腹部溃疡，腹泻，坏死因子诱导的胃损伤，毛发生长，血管舒缩或过敏性鼻炎，支气管疾病或膀胱疾病。

    Thieno-[2,3-d]pyrimidine and thieno-pyridazine compounds and methods of use
    4.
    发明授权
    Thieno-[2,3-d]pyrimidine and thieno-pyridazine compounds and methods of use 失效
    噻吩并[2,3-d]嘧啶和噻吩并哒嗪化合物及其使用方法

    公开(公告)号：US08247409B2

    公开(公告)日：2012-08-21

    申请号：US12616646

    申请日：2009-11-11

    申请人： Fang-Tsao Hong ,  James R. Falsey ,  Seifu Tadesse ,  Andrew Tasker

    发明人： Fang-Tsao Hong ,  James R. Falsey ,  Seifu Tadesse ,  Andrew Tasker

    IPC分类号： A61K31/5052 ,  A61K31/5377 ,  C07D413/14 ,  C07D487/04 ,  A61P17/00 ,  A61P19/00 ,  A61P25/00 ,  A61P31/12 ,  A61P11/00

    CPC分类号： C07D495/04

    摘要： The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I wherein A1, A2, B, R2 and R3 are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, uses of such compounds and compositions for treatment of kinase mediated diseases including rheumatoid arthritis, psoriasis and other inflammation disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I.

    摘要翻译： 本发明包括一类新的可用于预防和治疗蛋白激酶介导的疾病，包括炎症和相关病症的化合物。 该化合物具有通式I，其中A1，A2，B，R2和R3在本文中定义。 本发明还包括药物组合物，其包含一种或多种式I化合物，这些化合物和组合物用于治疗激酶介导的疾病包括类风湿性关节炎，牛皮癣和其它炎症疾病的用途，以及可用于制备 一级方程式

    Thieno-[2,3-d]Pyrimidine and Thieno-Pyridazine Compounds and Methods of Use
    10.
    发明申请
    Thieno-[2,3-d]Pyrimidine and Thieno-Pyridazine Compounds and Methods of Use 失效
    噻吩并[2,3-d]嘧啶和噻吩并哒嗪化合物及其使用方法

    公开(公告)号：US20100125074A1

    公开(公告)日：2010-05-20

    申请号：US12616646

    申请日：2009-11-11

    申请人： Fang-Tsao Hong ,  James R. Falsey ,  Robert M. Rzasa ,  Seifu Tadesse ,  Andrew Tasker

    发明人： Fang-Tsao Hong ,  James R. Falsey ,  Robert M. Rzasa ,  Seifu Tadesse ,  Andrew Tasker

    IPC分类号： A61K31/5025 ,  C07D413/14 ,  C07D487/04 ,  A61K31/5377 ,  A61P17/00 ,  A61P19/00 ,  A61P25/00 ,  A61P31/12 ,  A61P11/00

    CPC分类号： C07D495/04

    摘要： The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I wherein A1, A2, B, R2 and R3 are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, uses of such compounds and compositions for treatment of kinase mediated diseases including rheumatoid arthritis, psoriasis and other inflammation disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I.

    摘要翻译： 本发明包括一类新的可用于预防和治疗蛋白激酶介导的疾病，包括炎症和相关病症的化合物。 该化合物具有通式I，其中A1，A2，B，R2和R3在本文中定义。 本发明还包括药物组合物，其包含一种或多种式I化合物，这些化合物和组合物用于治疗激酶介导的疾病包括类风湿性关节炎，牛皮癣和其它炎症疾病的用途，以及可用于制备 一级方程式