发明申请
- 专利标题: PROCESS FOR PREPARING METHACRYLIC ACID OR METHACRYLIC ESTERS
- 专利标题(中): 制备甲基丙烯酸或甲基丙烯酸酯的方法
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申请号: US12602593申请日: 2008-05-30
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公开(公告)号: US20100291644A1公开(公告)日: 2010-11-18
- 发明人: Achim Marx , Markus Poetter , Stefan Buchholz , Alexander May , Hermann Siegert , Birgit Alber , Georg Fuchs , Lothar Eggeling
- 申请人: Achim Marx , Markus Poetter , Stefan Buchholz , Alexander May , Hermann Siegert , Birgit Alber , Georg Fuchs , Lothar Eggeling
- 申请人地址: DE Darmstadt
- 专利权人: Evonik Roehm GmbH
- 当前专利权人: Evonik Roehm GmbH
- 当前专利权人地址: DE Darmstadt
- 优先权: EPPCT/EP2007/055394 20070601
- 国际申请: PCT/EP08/56707 WO 20080530
- 主分类号: C12P7/62
- IPC分类号: C12P7/62 ; C12P7/40 ; C12P7/44
摘要:
The present invention relates to a process for the preparation of methacrylic acid or methacrylic esters, comprising the process steps of IA) preparation of 3-hydroxyisobutyric acid by a process comprising the process step of bringing a cell which has been genetically modified in comparison with its wild type in such a way that it is capable of forming more 3-hydroxyisobutyric acid, or polyhydroxyalkanoates based on 3-hydroxyisobutyric acid in comparison with its wild type, into contact with a nutrient medium comprising, as carbon source, carbohydrates, glycerol, carbon dioxide, methanol, L-valine or L-glutamate under conditions under which 3-hydroxyisobutyric acid or polyhydroxyalkanoates based on 3-hydroxyisobutyric acid are formed from the carbon source, if appropriate, isolation of the 3-hydroxyisobutyric acid from the nutrient medium and also, if appropriate, neutralization of the 3-hydroxyisobutyric acid, IB) dehydration of the 3-hydroxyisobutyric acid with formation of methacrylic acid and also, where appropriate, esterification methacrylic acid. The invention also relates to a process for the preparation of polymethacrylic acid or polymethacrylic esters.
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