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    PROCESS FOR PREPARING METHACRYLIC ACID OR METHACRYLIC ESTERS
    1.
    发明申请
    PROCESS FOR PREPARING METHACRYLIC ACID OR METHACRYLIC ESTERS 有权
    制备甲基丙烯酸或甲基丙烯酸酯的方法

    公开(公告)号：US20100291644A1

    公开(公告)日：2010-11-18

    申请号：US12602593

    申请日：2008-05-30

    申请人： Achim Marx ,  Markus Poetter ,  Stefan Buchholz ,  Alexander May ,  Hermann Siegert ,  Birgit Alber ,  Georg Fuchs ,  Lothar Eggeling

    发明人： Achim Marx ,  Markus Poetter ,  Stefan Buchholz ,  Alexander May ,  Hermann Siegert ,  Birgit Alber ,  Georg Fuchs ,  Lothar Eggeling

    IPC分类号： C12P7/62 ,  C12P7/40 ,  C12P7/44

    CPC分类号： C12P7/42 ,  C08F120/06 ,  C08F120/10 ,  C12N9/0008 ,  C12N9/001 ,  C12N9/1096 ,  C12N9/16 ,  C12N9/88 ,  C12P7/40 ,  C12P7/52 ,  C12P7/625 ,  C12Y102/04004 ,  C12Y103/99012 ,  C12Y206/01042 ,  C12Y301/02004 ,  C12Y402/01017

    摘要： The present invention relates to a process for the preparation of methacrylic acid or methacrylic esters, comprising the process steps of IA) preparation of 3-hydroxyisobutyric acid by a process comprising the process step of bringing a cell which has been genetically modified in comparison with its wild type in such a way that it is capable of forming more 3-hydroxyisobutyric acid, or polyhydroxyalkanoates based on 3-hydroxyisobutyric acid in comparison with its wild type, into contact with a nutrient medium comprising, as carbon source, carbohydrates, glycerol, carbon dioxide, methanol, L-valine or L-glutamate under conditions under which 3-hydroxyisobutyric acid or polyhydroxyalkanoates based on 3-hydroxyisobutyric acid are formed from the carbon source, if appropriate, isolation of the 3-hydroxyisobutyric acid from the nutrient medium and also, if appropriate, neutralization of the 3-hydroxyisobutyric acid, IB) dehydration of the 3-hydroxyisobutyric acid with formation of methacrylic acid and also, where appropriate, esterification methacrylic acid. The invention also relates to a process for the preparation of polymethacrylic acid or polymethacrylic esters.

    摘要翻译： 本发明涉及一种制备甲基丙烯酸或甲基丙烯酸酯的方法，其包括以下工艺步骤：IA）通过包括以下步骤的方法制备3-羟基异丁酸，所述方法包括将经遗传修饰的细胞与其 野生型，使得其能够形成更多的3-羟基异丁酸或与其野生型相比基于3-羟基异丁酸的聚羟基链烷酸酯与营养培养基接触，所述营养培养基包含作为碳源的碳水化合物，甘油，碳 二氧化物，甲醇，L-缬氨酸或L-谷氨酸盐，其中3-羟基异丁酸或基于3-羟基异丁酸的聚羟基链烷酸酯由碳源形成的条件下，如果合适，则从营养培养基中分离出3-羟基异丁酸， 如果适当，中和3-羟基异丁酸，IB）3-羟基异丁酸脱水形成甲基丙烯酸 酸，并且在适当的情况下酯化甲基丙烯酸。 本发明还涉及一种制备聚甲基丙烯酸或聚甲基丙烯酸酯的方法。

    Process for preparing methacrylic acid or methacrylic esters
    2.
    发明授权
    Process for preparing methacrylic acid or methacrylic esters 有权
    制备甲基丙烯酸或甲基丙烯酸酯的方法

    公开(公告)号：US09234218B2

    公开(公告)日：2016-01-12

    申请号：US12602593

    申请日：2008-05-30

    申请人： Achim Marx ,  Markus Poetter ,  Stefan Buchholz ,  Alexander May ,  Hermann Siegert ,  Birgit Alber ,  Georg Fuchs ,  Lothar Eggeling

    发明人： Achim Marx ,  Markus Poetter ,  Stefan Buchholz ,  Alexander May ,  Hermann Siegert ,  Birgit Alber ,  Georg Fuchs ,  Lothar Eggeling

    IPC分类号： C12P7/42 ,  C12P7/52 ,  C12N9/02 ,  C12P7/40 ,  C12P7/62 ,  C08F120/06 ,  C08F120/10 ,  C12N9/10 ,  C12N9/16 ,  C12N9/88

    CPC分类号： C12P7/42 ,  C08F120/06 ,  C08F120/10 ,  C12N9/0008 ,  C12N9/001 ,  C12N9/1096 ,  C12N9/16 ,  C12N9/88 ,  C12P7/40 ,  C12P7/52 ,  C12P7/625 ,  C12Y102/04004 ,  C12Y103/99012 ,  C12Y206/01042 ,  C12Y301/02004 ,  C12Y402/01017

    摘要： The present invention relates to a process for the preparation of methacrylic acid or methacrylic esters, comprising the process steps of IA) preparation of 3-hydroxyisobutyric acid by a process comprising the process step of bringing a cell which has been genetically modified in comparison with its wild type in such a way that it is capable of forming more 3-hydroxyisobutyric acid, or polyhydroxyalkanoates based on 3-hydroxyisobutyric acid in comparison with its wild type, into contact with a nutrient medium comprising, as carbon source, carbohydrates, glycerol, carbon dioxide, methanol, L-valine or L-glutamate under conditions under which 3-hydroxyisobutyric acid or polyhydroxyalkanoates based on 3-hydroxyisobutyric acid are formed from the carbon source, if appropriate, isolation of the 3-hydroxyisobutyric acid from the nutrient medium and also, if appropriate, neutralization of the 3-hydroxyisobutyric acid, IB) dehydration of the 3-hydroxyisobutyric acid with formation of methacrylic acid and also, where appropriate, esterification methacrylic acid. The invention also relates to a process for the preparation of polymethacrylic acid or polymethacrylic esters.

    摘要翻译： 本发明涉及一种制备甲基丙烯酸或甲基丙烯酸酯的方法，其包括以下工艺步骤：IA）通过包括以下步骤的方法制备3-羟基异丁酸，所述方法包括将经遗传修饰的细胞与其 野生型，使得其能够形成更多的3-羟基异丁酸或与其野生型相比基于3-羟基异丁酸的聚羟基链烷酸酯与营养培养基接触，所述营养培养基包含作为碳源的碳水化合物，甘油，碳 二氧化物，甲醇，L-缬氨酸或L-谷氨酸盐，其中3-羟基异丁酸或基于3-羟基异丁酸的聚羟基链烷酸酯由碳源形成的条件下，如果合适，则从营养培养基中分离出3-羟基异丁酸， 如果适当，中和3-羟基异丁酸，IB）3-羟基异丁酸脱水形成甲基丙烯酸 酸，并且在适当的情况下酯化甲基丙烯酸。 本发明还涉及一种制备聚甲基丙烯酸或聚甲基丙烯酸酯的方法。

    Microbiological Production of 3-Hydroxypropionic Acid
    4.
    发明申请
    Microbiological Production of 3-Hydroxypropionic Acid 审中-公开
    微生物生产3-羟基丙酸

    公开(公告)号：US20090325248A1

    公开(公告)日：2009-12-31

    申请号：US12067266

    申请日：2006-10-09

    申请人： Achim Marx ,  Volker F. Wendisch ,  Doris Rittmann ,  Stefan Buchholz

    发明人： Achim Marx ,  Volker F. Wendisch ,  Doris Rittmann ,  Stefan Buchholz

    IPC分类号： C12P7/52 ,  C12N1/20 ,  C12N15/74

    CPC分类号： C12P7/40 ,  C12P7/42 ,  C12P7/44

    摘要： The present invention relates to a cell which is genetically modified in relation to its wild type and which exhibits at least one of the properties a) or b): a) an increased activity by comparison with its wild type of an enzyme E1 which catalyzes the conversion of pyruvate into oxaloacetate, or of an enzyme E1b which catalyzes the conversion of phosphoenolpyruvate into oxaloacetate, b) an increased activity by comparison with its wild type of an enzyme E2 which catalyzes the conversion of aspartate into beta-alanine, where, besides properties a) or b), the cell is characterized by at least one of the properties c) or d) c) the genetically modified cell is able to export beta-alanine out of the cell, d) the genetically modified cell is able to convert beta-alanine into 3-hydroxypropionic acid. The invention also relates to methods for producing a genetically modified cell, to the genetically modified cells obtainable by this method, to methods for producing 3-hydroxypropionic acid, to a method for producing acrylic acid, to a method for producing polyacrylates, to a method for producing acrylic esters, and to the use of cells for producing 3-hydroxypropionic acid.

    摘要翻译： 本发明涉及一种相对于其野生型进行遗传修饰的细胞，其表现出以下特征中的至少一种：a）或b）：a）通过与其野生型的酶E1相比增加活性，所述酶E1催化 或丙酮酸转化为草酰乙酸的酶E1b或催化磷酸烯醇丙酮酸转化为草酰乙酸的酶E1b; b）通过与其野生型的催化天冬氨酸转化成β-丙氨酸的酶E2的活性相比增加活性， a）或b），所述细胞的特征在于c）或d）中的至少一个c）所述遗传修饰的细胞能够将β-丙氨酸从细胞中出来，d）转基因细胞能够转化 β-丙氨酸转化为3-羟基丙酸。 本发明还涉及生产聚丙烯酸酯的方法，生产丙烯酸的方法，生产聚丙烯酸酯的方法，生产聚丙烯酸酯的方法，生产聚丙烯酸酯的方法，生产聚丙烯酸酯的方法 用于制备丙烯酸酯，以及用于生产3-羟基丙酸的细胞。

    Process for preparing optically active beta-aminocarboxylic acids from racemic n-acylated beta-aminocarboxylic acids
    6.
    发明申请
    Process for preparing optically active beta-aminocarboxylic acids from racemic n-acylated beta-aminocarboxylic acids 审中-公开
    从外消旋的N-酰化β-氨基羧酸制备光学活性β-氨基羧酸的方法

    公开(公告)号：US20050153401A1

    公开(公告)日：2005-07-14

    申请号：US10508088

    申请日：2003-03-07

    申请人： Harald Groger ,  Harald Trauthwein ,  Karlheinz Drauz ,  Stefan Buchholz ,  Christiane Sacherer ,  Helge Werner

    发明人： Harald Groger ,  Harald Trauthwein ,  Karlheinz Drauz ,  Stefan Buchholz ,  Christiane Sacherer ,  Helge Werner

    IPC分类号： C12P41/00 ,  C12R1/69 ,  C12P13/04

    CPC分类号： C12P41/007

    摘要： A process is described for preparing optically active β-atninocarboxylic acids from racemic N-acylated β-aminocarboxylic acids by cnantiosclccthc hydrolysis of the N-acylated β-aminocarboxylic acid in the presence of a hydrolase by way of biocatalyst, wherein the N-acyl substituent of the N-acylated β-aminocarboxylic acid (I) exhibits Structure I in which R1, R2 are each selected, independently of one another, from H, halogen, alkiyl residues, OH, alkoxy residues and aryloxy residues; R3 is selected from halogen, alkoxy residues and aryloxy residues; (II) Structure IIA or IIB or the structure of the corresponding salts or (III) Structure III or the structure of the corresponding salt.

    摘要翻译： 描述了一种用于通过在水解酶存在下通过生物催化剂的N-酰化β-氨基羧酸水解N-外酰基化的β-氨基羧酸来制备光学活性β-阿魏酸的方法，其中N-酰基取代基 的N-酰化的β-氨基羧酸（I）表现出结构I，其中R 1，R 2各自彼此独立地选自H，卤素， 烷基残基，OH，烷氧基残基和芳氧基残基; R 3选自卤素，烷氧基残基和芳氧基残基; （II）结构IIA或IIB或相应盐的结构或（III）结构III或相应盐的结构。

    Citric ester mixtures and their use
    9.
    发明授权
    Citric ester mixtures and their use 失效
    柠檬酸酯混合物及其用途

    公开(公告)号：US08431638B2

    公开(公告)日：2013-04-30

    申请号：US12990225

    申请日：2009-05-05

    申请人： Michael Grass ,  Stefan Buchholz ,  Wilfried Bueschken

    发明人： Michael Grass ,  Stefan Buchholz ,  Wilfried Bueschken

    IPC分类号： C08K5/10

    CPC分类号： C07C69/704 ,  C08K5/0016 ,  C08K5/11

    摘要： The present invention relates to mixtures of citric esters of the formula I, in which each of R1, R2 and R3 is an aliphatic C5 or C9 moiety, wherein the average chain length of the aliphatic moieties in the mixture is in the range from greater than 5 to 7, and the average degree of branching of the aliphatic C9 moieties is in the range from 0.9 to 2.2. The present invention also relates to the use of the citric ester mixture as a plasticizer in plastics compositions.

    摘要翻译： 本发明涉及式I的柠檬酸酯的混合物，其中R 1，R 2和R 3各自为脂族C 5或C 9部分，其中混合物中脂族部分的平均链长在大于 5至7，并且脂族C 9部分的平均支化度在0.9至2.2的范围内。 本发明还涉及柠檬酸酯混合物作为塑料组合物中的增塑剂的用途。

    CITRIC ESTER MIXTURES AND THEIR USE
    10.
    发明申请
    CITRIC ESTER MIXTURES AND THEIR USE 失效
    CITRIC ESTER MIXTURES及其使用

    公开(公告)号：US20110046283A1

    公开(公告)日：2011-02-24

    申请号：US12990225

    申请日：2009-05-05

    申请人： Michael Grass ,  Stefan Buchholz ,  Wilfried Bueschken

    发明人： Michael Grass ,  Stefan Buchholz ,  Wilfried Bueschken

    IPC分类号： C08K5/12 ,  C08K5/11 ,  C09K3/00

    CPC分类号： C07C69/704 ,  C08K5/0016 ,  C08K5/11

    摘要： The present invention relates to mixtures of citric esters of the formula I, in which each of R1, R2 and R3 is an aliphatic C5 or C9 moiety, characterized in that the average chain length of the aliphatic moieties in the mixture is in the range from greater than 5 to 7, and the average degree of branching of the aliphatic C9 moieties is in the range from 0.9 to 2.2.The present invention also relates to the use of the citric ester mixture according to the invention as plasticizer in plastics compositions.The present invention also relates to a composition comprising the citric ester mixture according to the invention in a mixture with further components, comprising plasticizers from the group of the alkyl esters of aromatic polycarboxylic acids, of the cyclohexanepolycarboxylic acids, of benzoic acid or of adipic acid, and also to the use of this type of plasticizer composition in plastics compositions, in adhesives, in sealing compounds, in coatings, in paints, in plastisols or in inks. Plastics products produced from the plasticizers according to the invention can be, for example: profiles, gaskets, food packaging, foils, toys, medical items, roof sheeting, synthetic leather, floor coverings, underbody protection, coated textiles, wallpapers, cables and wire sheathing.

    摘要翻译： 本发明涉及式I的柠檬酸酯的混合物，其中R 1，R 2和R 3各自为脂族C 5或C 9部分，其特征在于混合物中脂族部分的平均链长在 大于5至7，并且脂族C 9部分的平均支化度在0.9至2.2的范围内。 本发明还涉及根据本发明的柠檬酸酯混合物在塑料组合物中作为增塑剂的用途。 本发明还涉及包含根据本发明的柠檬酸酯混合物与其它组分的混合物的组合物，其包含来自芳族多元羧酸的烷基酯，环己烷多羧酸，苯甲酸或己二酸的增塑剂 ，以及在塑料组合物，粘合剂，密封化合物，涂料，涂料，增塑溶胶或油墨中使用这种类型的增塑剂组合物。 根据本发明的由增塑剂生产的塑料产品可以是例如型材，垫圈，食品包装，箔，玩具，医疗用品，屋顶板，合成皮革，地板覆盖物，底部保护，涂布纺织品，壁纸，电缆和线 护套