发明申请
US20100317625A1 NOVEL SULFONAMIDOMETHYLPHOSPHONATE INHIBITORS OF BETA-LACTAMASE
审中-公开
β-乳酸酶的新型磺酰亚胺磷酸盐抑制剂
- 专利标题： NOVEL SULFONAMIDOMETHYLPHOSPHONATE INHIBITORS OF BETA-LACTAMASE
- 专利标题（中）： β-乳酸酶的新型磺酰亚胺磷酸盐抑制剂
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申请号： US12301793申请日： 2007-05-21
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公开(公告)号： US20100317625A1公开(公告)日： 2010-12-16
- 发明人: Frank Dininno , Milton L. Hammond , Kevin Dykstra , Seongkon Kim , Qiang Tan , Katherine Young , Jeffrey Donald Hermes , Stephane Raeppel , Michael Mannion , Nancy Z. Zhou , Frederic Gaudette , Arkadii Vaisburg , Jubrail Rahil , Nafsika Georgopapadakou
- 申请人： Frank Dininno , Milton L. Hammond , Kevin Dykstra , Seongkon Kim , Qiang Tan , Katherine Young , Jeffrey Donald Hermes , Stephane Raeppel , Michael Mannion , Nancy Z. Zhou , Frederic Gaudette , Arkadii Vaisburg , Jubrail Rahil , Nafsika Georgopapadakou
- 国际申请： PCT/US2007/011977 WO 20070521
- 主分类号： A61K31/675
- IPC分类号： A61K31/675 ; C07F9/6553 ; A61K31/67 ; C07F9/6561 ; C07F9/6539 ; C07F9/655 ; A61K31/665 ; A61P31/04
摘要：
This invention provides novel β-lactamase inhibitors of the aryl- and heteroaryl-sulfonamidomethylphosphonate monoester class. The compounds inhibit three classes of β-lactamases and synergize the antibacterial effects of β-lactam antibiotics (e.g., imipenem and ceftazimdime) against those micro-organisms normally resistant to the β-lactam antibiotics as a result of the presence of the β-lactamases.
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