发明申请
US20110003384A1 COMPOSITIONS AND METHODS OF USE FOR MGD-CSF IN DISEASE TREATMENT
有权
MGD-CSF在疾病治疗中的组合物和使用方法
- 专利标题: COMPOSITIONS AND METHODS OF USE FOR MGD-CSF IN DISEASE TREATMENT
- 专利标题(中): MGD-CSF在疾病治疗中的组合物和使用方法
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申请号: US12370559申请日: 2009-02-12
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公开(公告)号: US20110003384A1公开(公告)日: 2011-01-06
- 发明人: Dirk BEHRENS , Elizabeth Bosch , Stephen K. Doberstein , Robert Forgan Halenbeck , Kevin Hestir , Min Mei Huang , Ernestine Lee , Haishan Lin , Thomas Linnemann , Shannon Marshall , Justin G. P. Wong , Ge Wu , Aileen Zhou , Cindy Leo , Lewis T. Williams
- 申请人: Dirk BEHRENS , Elizabeth Bosch , Stephen K. Doberstein , Robert Forgan Halenbeck , Kevin Hestir , Min Mei Huang , Ernestine Lee , Haishan Lin , Thomas Linnemann , Shannon Marshall , Justin G. P. Wong , Ge Wu , Aileen Zhou , Cindy Leo , Lewis T. Williams
- 专利权人: Five Prime Therapeutics, Inc.
- 当前专利权人: Five Prime Therapeutics, Inc.
- 主分类号: C12N5/071
- IPC分类号: C12N5/071
摘要:
Disclosed is a newly identified secreted molecule, identified herein as “monocyte, granulocyte, and dendritic cell colony stimulating factor” (MGD-CSF), the polypeptide sequence, and polynucleotides encoding the polypeptide sequence. Also provided is a procedure for producing the polypeptide by recombinant techniques employing, for example, vectors and host cells. Additionally, procedures are described to modify the disclosed novel molecules of the invention to prepare fusion molecules. Also disclosed are methods for using the polypeptides and active fragments thereof for treatment of a variety of diseases, including, for example, cancer, autoimmune and inflammatory diseases, infectious diseases, and recurrent pregnancy loss.