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公开(公告)号：US08575312B2
公开(公告)日：2013-11-05
申请号：US13446254
申请日：2012-04-13
申请人： Dirk Behrens , Elizabeth Bosch , Stephen K. Doberstein , Robert Forgan Halenbeck , Kevin Hestir , Min Mei Huang , Ernestine Lee , Haishan Lin , Thomas Linnemann , Shannon Marshall , Justin G. P. Wong , Ge Wu , Aileen Zhou , Cindy Leo , Lewis T. Williams
发明人： Dirk Behrens , Elizabeth Bosch , Stephen K. Doberstein , Robert Forgan Halenbeck , Kevin Hestir , Min Mei Huang , Ernestine Lee , Haishan Lin , Thomas Linnemann , Shannon Marshall , Justin G. P. Wong , Ge Wu , Aileen Zhou , Cindy Leo , Lewis T. Williams
IPC分类号： C07K14/00
CPC分类号： C07K16/243 , A61K38/00 , C07K14/53
摘要： Disclosed is a newly identified secreted molecule, identified herein as “monocyte, granulocyte, and dendritic cell colony stimulating factor” (MGD-CSF), the polypeptide sequence, and polynucleotides encoding the polypeptide sequence. Also provided is a procedure for producing the polypeptide by recombinant techniques employing, for example, vectors and host cells. Additionally, procedures are described to modify the disclosed novel molecules of the invention to prepare fusion molecules. Also disclosed are methods for using the polypeptides and active fragments thereof for treatment of a variety of diseases, including, for example, cancer, autoimmune and inflammatory diseases, infectious diseases, and recurrent pregnancy loss.
摘要翻译： 公开了一种新鉴定的分泌型分子，本文称为“单核细胞，粒细胞和树突细胞集落刺激因子”（MGD-CSF），多肽序列和编码多肽序列的多核苷酸。 还提供了通过使用例如载体和宿主细胞的重组技术产生多肽的方法。 另外，描述了修饰所公开的本发明新颖分子以制备融合分子的方法。 还公开了将多肽及其活性片段用于治疗各种疾病（包括例如癌症，自身免疫性和炎性疾病，感染性疾病和复发性妊娠损失）的方法。
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公开(公告)号：US20110003384A1
公开(公告)日：2011-01-06
申请号：US12370559
申请日：2009-02-12
申请人： Dirk BEHRENS , Elizabeth Bosch , Stephen K. Doberstein , Robert Forgan Halenbeck , Kevin Hestir , Min Mei Huang , Ernestine Lee , Haishan Lin , Thomas Linnemann , Shannon Marshall , Justin G. P. Wong , Ge Wu , Aileen Zhou , Cindy Leo , Lewis T. Williams
发明人： Dirk BEHRENS , Elizabeth Bosch , Stephen K. Doberstein , Robert Forgan Halenbeck , Kevin Hestir , Min Mei Huang , Ernestine Lee , Haishan Lin , Thomas Linnemann , Shannon Marshall , Justin G. P. Wong , Ge Wu , Aileen Zhou , Cindy Leo , Lewis T. Williams
IPC分类号： C12N5/071
CPC分类号： C07K16/243 , A61K38/00 , C07K14/53
摘要： Disclosed is a newly identified secreted molecule, identified herein as “monocyte, granulocyte, and dendritic cell colony stimulating factor” (MGD-CSF), the polypeptide sequence, and polynucleotides encoding the polypeptide sequence. Also provided is a procedure for producing the polypeptide by recombinant techniques employing, for example, vectors and host cells. Additionally, procedures are described to modify the disclosed novel molecules of the invention to prepare fusion molecules. Also disclosed are methods for using the polypeptides and active fragments thereof for treatment of a variety of diseases, including, for example, cancer, autoimmune and inflammatory diseases, infectious diseases, and recurrent pregnancy loss.
摘要翻译： 公开了一种新鉴定的分泌型分子，本文称为“单核细胞，粒细胞和树突细胞集落刺激因子”（MGD-CSF），多肽序列和编码多肽序列的多核苷酸。 还提供了通过使用例如载体和宿主细胞的重组技术产生多肽的方法。 另外，描述了修饰所公开的本发明新颖分子以制备融合分子的方法。 还公开了将多肽及其活性片段用于治疗各种疾病（包括例如癌症，自身免疫性和炎性疾病，感染性疾病和复发性妊娠损失）的方法。
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公开(公告)号：US08178109B2
公开(公告)日：2012-05-15
申请号：US12370559
申请日：2009-02-12
申请人： Dirk Behrens , Elizabeth Bosch , Stephen K. Doberstein , Robert Forgan Halenbeck , Kevin Hestir , Min Mei Huang , Ernestine Lee , Haishan Lin , Thomas Linnemann , Shannon Marshall , Justin G. P. Wong , Ge Wu , Aileen Zhou , Cindy Leo , Lewis T. Williams
发明人： Dirk Behrens , Elizabeth Bosch , Stephen K. Doberstein , Robert Forgan Halenbeck , Kevin Hestir , Min Mei Huang , Ernestine Lee , Haishan Lin , Thomas Linnemann , Shannon Marshall , Justin G. P. Wong , Ge Wu , Aileen Zhou , Cindy Leo , Lewis T. Williams
IPC分类号： A61K39/00
CPC分类号： C07K16/243 , A61K38/00 , C07K14/53
摘要： Disclosed is a newly identified secreted molecule, identified herein as “monocyte, granulocyte, and dendritic cell colony stimulating factor” (MGD-CSF), the polypeptide sequence, and polynucleotides encoding the polypeptide sequence. Also provided is a procedure for producing the polypeptide by recombinant techniques employing, for example, vectors and host cells. Additionally, procedures are described to modify the disclosed novel molecules of the invention to prepare fusion molecules. Also disclosed are methods for using the polypeptides and active fragments thereof for treatment of a variety of diseases, including, for example, cancer, autoimmune and inflammatory diseases, infectious diseases, and recurrent pregnancy loss.
摘要翻译： 公开了一种新鉴定的分泌型分子，本文称为“单核细胞，粒细胞和树突细胞集落刺激因子”（MGD-CSF），多肽序列和编码多肽序列的多核苷酸。 还提供了通过使用例如载体和宿主细胞的重组技术产生多肽的方法。 另外，描述了修饰所公开的本发明新颖分子以制备融合分子的方法。 还公开了将多肽及其活性片段用于治疗各种疾病（包括例如癌症，自身免疫性和炎性疾病，感染性疾病和复发性妊娠损失）的方法。
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公开(公告)号：US20120258071A1
公开(公告)日：2012-10-11
申请号：US13446254
申请日：2012-04-13
申请人： Dirk Behrens , Elizabeth Bosch , Stephen K. Doberstein , Robert Forgan Halenbeck , Kevin Hestir , Min Mei Huang , Ernestine Lee , Haishan Lin , Thomas Linnemann , Shannon Marshall , Justin G. P. Wong , Ge Wu , Aileen Zhou , Cindy Leo , Lewis T. Williams
发明人： Dirk Behrens , Elizabeth Bosch , Stephen K. Doberstein , Robert Forgan Halenbeck , Kevin Hestir , Min Mei Huang , Ernestine Lee , Haishan Lin , Thomas Linnemann , Shannon Marshall , Justin G. P. Wong , Ge Wu , Aileen Zhou , Cindy Leo , Lewis T. Williams
CPC分类号： C07K16/243 , A61K38/00 , C07K14/53
摘要： Disclosed is a newly identified secreted molecule, identified herein as “monocyte, granulocyte, and dendritic cell colony stimulating factor” (MGD-CSF), the polypeptide sequence, and polynucleotides encoding the polypeptide sequence. Also provided is a procedure for producing the polypeptide by recombinant techniques employing, for example, vectors and host cells. Additionally, procedures are described to modify the disclosed novel molecules of the invention to prepare fusion molecules. Also disclosed are methods for using the polypeptides and active fragments thereof for treatment of a variety of diseases, including, for example, cancer, autoimmune and inflammatory diseases, infectious diseases, and recurrent pregnancy loss.
摘要翻译： 公开了一种新鉴定的分泌型分子，本文鉴定为单核细胞，粒细胞和树突细胞集落刺激因子（MGD-CSF），多肽序列和编码多肽序列的多核苷酸。 还提供了通过使用例如载体和宿主细胞的重组技术产生多肽的方法。 另外，描述了修饰所公开的本发明新颖分子以制备融合分子的方法。 还公开了将多肽及其活性片段用于治疗各种疾病（包括例如癌症，自身免疫性和炎性疾病，感染性疾病和复发性妊娠损失）的方法。
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公开(公告)号：US20070264277A1
公开(公告)日：2007-11-15
申请号：US11632319
申请日：2005-07-21
申请人： Dirk Behrens , Elizabeth Bosch , Stephen Doberstein , Robert Halenbeck , Kevin Hestir , Min Huang , Ernestine Lee , Haishan Lin , Thomas Linnemann , Shannon Marshall , Justin Wong , Ge Wu , Aileen Zhou
发明人： Dirk Behrens , Elizabeth Bosch , Stephen Doberstein , Robert Halenbeck , Kevin Hestir , Min Huang , Ernestine Lee , Haishan Lin , Thomas Linnemann , Shannon Marshall , Justin Wong , Ge Wu , Aileen Zhou
IPC分类号： A61K39/00 , A61K38/00 , C07H21/00 , C07K14/00 , C07K16/18 , C12N15/00 , C12N15/87 , C12N5/06 , C12P1/00 , G01N33/53
CPC分类号： C07K16/243 , A61K38/00 , C07K14/53
摘要： Disclosed is a newly identified secreted molecule, identified herein as “monocyte, granulocyte, and dendritic cell colony stimulating factor” (MGD-CSF), the polypeptide sequence, and polynucleotides encoding the polypeptide sequence. Also provided is a procedure for producing the polypeptide by recombinant techniques employing, for example, vectors and host cells. Additionally, procedures are described to modify the disclosed novel molecules of the invention to prepare fusion molecules. Also disclosed are methods for using the polypeptides and active fragments thereof for treatment of a variety of diseases, including, for example, cancer, autoimmune and inflammatory diseases, infectious diseases, and recurrent pregnancy loss.
摘要翻译： 公开了一种新鉴定的分泌型分子，本文称为“单核细胞，粒细胞和树突细胞集落刺激因子”（MGD-CSF），多肽序列和编码多肽序列的多核苷酸。 还提供了通过使用例如载体和宿主细胞的重组技术产生多肽的方法。 另外，描述了修饰所公开的本发明新颖分子以制备融合分子的方法。 还公开了将多肽及其活性片段用于治疗各种疾病（包括例如癌症，自身免疫性和炎性疾病，感染性疾病和复发性妊娠损失）的方法。
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6.发明申请Leader Sequences For Directing Secretion of Polypeptides and Methods For Production Thereof 审中-公开用于引导多肽分泌的前导序列及其生产方法公开(公告)号：US20080286834A1
公开(公告)日：2008-11-20
申请号：US11883065
申请日：2006-01-27
CPC分类号： C07K14/47
摘要： The present invention provides leader sequences that are useful for the production of heterologous secretable polypeptides; heterologous secreted polypeptides; nucleic acid constructs that encode such leader sequences and heterologous secreted polynucleotides; vectors that contain such nucleic acid constructs; recombinant host cells that contain such nucleic acid constructs; vectors, polypeptides, and methods of making and using such secreted polypeptides with such heterologous leader sequences.
摘要翻译： 本发明提供可用于产生异源可分泌多肽的前导序列; 异源分泌多肽; 编码这种前导序列和异源分泌多核苷酸的核酸构建体; 含有此类核酸构建体的载体; 含有此类核酸构建体的重组宿主细胞; 载体，多肽，以及使用这种分泌的多肽与这种异源前导序列的方法。
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7.发明申请Novel Apo2L and IL-24 Polypeptides, Polynucleotides, and Methods of Their Use 审中-公开新型Apo2L和IL-24多肽，多核苷酸及其使用方法公开(公告)号：US20080242603A1
公开(公告)日：2008-10-02
申请号：US10589561
申请日：2005-02-18
申请人： Yan Wang , Amy L. Tsui Collins , Kevin Hestir , Ernestine Lee , Forgan Robert Halenbeck , Elizabeth Bosch , Thomas Linnemann , Lewis Thomas Williams
发明人： Yan Wang , Amy L. Tsui Collins , Kevin Hestir , Ernestine Lee , Forgan Robert Halenbeck , Elizabeth Bosch , Thomas Linnemann , Lewis Thomas Williams
CPC分类号： C07K14/70575 , C07K14/54
摘要： Disclosed are newly identified Interleukin 24 and APO2L splice variant molecules, their polypeptide sequences, and the polynucleotides encoding the polypeptide sequences. Also provided is a procedure for producing such polypeptides by recombinant techniques employing, for example, vectors and host cells, and, for example, heterologous secretory leader sequences. Also disclosed are methods for using such polypeptides and modulators thereof for the treatment of diseases, including cancer, immune diseases, infectious diseases, and ischemic diseases.
摘要翻译： 公开了新鉴定的白细胞介素24和APO2L剪接变体分子，其多肽序列和编码多肽序列的多核苷酸。 还提供了通过使用例如载体和宿主细胞以及例如异源分泌前导序列的重组技术产生此类多肽的方法。 还公开了使用这些多肽及其调节剂用于治疗包括癌症，免疫疾病，感染性疾病和缺血性疾病在内的疾病的方法。
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8.发明申请Compositions and Methods for Treating Diseases, Disorders, or Conditions Characterized by Myelin Degeneration, Myelin Deficiency or Loss 审中-公开治疗由髓磷脂退化，髓鞘缺乏或损失表征的疾病，疾病或病症的组合物和方法公开(公告)号：US20100210829A1
公开(公告)日：2010-08-19
申请号：US12530447
申请日：2008-03-07
IPC分类号： C07H21/04
CPC分类号： C07K14/4713 , C07K14/47
摘要： Provided herein are novel polypeptides, polynucleotides and compositions containing such, and to methods useful in treating diseases, disorders, or conditions of the central nervous system (CNS) associated with demyelination. The novel polypeptides, polynucleotides stimulate oligodendrocyte precursor cell (OPC), and are capable of promoting myelination or remyelination in a subject.
摘要翻译： 本文提供了新型多肽，多核苷酸和含有此类物质的组合物，以及可用于治疗与脱髓鞘相关的中枢神经系统（CNS）的疾病，病症或病症的方法。 新型多肽，多核苷酸刺激少突胶质细胞前体细胞（OPC），并且能够促进受试者的髓鞘形成或髓鞘再生。
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公开(公告)号：US20070160816A1
公开(公告)日：2007-07-12
申请号：US10580702
申请日：2004-11-26
申请人： Thomas Linnemann
发明人： Thomas Linnemann
IPC分类号： B32B3/00
CPC分类号： B44C5/0476 , B32B27/04 , B32B2038/0076 , B32B2305/30 , B32B2307/554 , B32B2317/125 , B32B2391/00 , B32B2451/00 , B44C5/0469 , Y10T428/24876
摘要： A method is described for producing a decorative laminate including: providing a decorative layer, applying a mixture of a thermohardening synthetic resin and hard particles to said layer, pressing the decorative layer and the mixture in a hot press at a press temperature in order to obtain a laminate, the mixture also containing a wax whose melting point is less than approximately 140° C. and/or by more than approximately 50° C. lower than the press temperature. A decorative laminate, a decorative laminate board and a method for producing a decorative prepreg sheet are also disclosed.
摘要翻译： 描述了一种用于生产装饰层压板的方法，其包括：提供装饰层，将热硬化合成树脂和硬质颗粒的混合物施加到所述层，在加压温度下在热压机中挤压装饰层和混合物，以获得 该混合物还含有熔点小于约140℃和/或比压制温度低约50℃的蜡。 还公开了装饰层压板，装饰性层压板以及装饰性预浸薄板的制造方法。
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公开(公告)号：US4960136A
公开(公告)日：1990-10-02
申请号：US335825
申请日：1989-04-10
申请人： Thomas Linnemann , Kurt Linnemann
发明人： Thomas Linnemann , Kurt Linnemann
CPC分类号： E04H1/1277 , A47K3/286 , A61G7/0005
摘要： A disposable decontamination device, comprising a foldable frame expandable to define a rectangular shape sized to accommodate a patient, a fluid resistant fabric formed into a basin sized to enclose said frame when positioning a patient on a backboard in one said basin and a collection vessel and drain means for transferring fluid from said basin to said vessel.
摘要翻译： 一种一次性净化装置，包括可膨胀以限定尺寸适于容纳患者的矩形形状的可折叠框架，当将患者定位在一个所述盆中的背板上时形成为尺寸设计成包围所述框架的流体抵抗织物和收集容器， 用于将流体从所述盆传送到所述容器的排出装置。
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