Invention Application
- Patent Title: ANTI-VEGF ANTIBODIES
- Patent Title (中): 抗VEGF抗体
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Application No.: US12768089Application Date: 2010-04-27
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Publication No.: US20110052575A1Publication Date: 2011-03-03
- Inventor: Manuel Baca , James A. Wells , Leonard G. Presta , Henry B. Lowman , Yvonne Man-yee Chen
- Applicant: Manuel Baca , James A. Wells , Leonard G. Presta , Henry B. Lowman , Yvonne Man-yee Chen
- Applicant Address: US CA South San Francisco
- Assignee: Genentech, Inc.
- Current Assignee: Genentech, Inc.
- Current Assignee Address: US CA South San Francisco
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/22 ; A61P35/00
Abstract:
Humanized and variant anti-VEGF antibodies and various uses therefor are disclosed. The anti-VEGF antibodies have strong binding affinities for VEGF; inhibit VEGF-induced proliferation of endothelial cells in vitro; and inhibit tumor growth in vivo.
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