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公开(公告)号:US20110052575A1
公开(公告)日:2011-03-03
申请号:US12768089
申请日:2010-04-27
IPC分类号: A61K39/395 , C07K16/22 , A61P35/00
CPC分类号: C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/92
摘要: Humanized and variant anti-VEGF antibodies and various uses therefor are disclosed. The anti-VEGF antibodies have strong binding affinities for VEGF; inhibit VEGF-induced proliferation of endothelial cells in vitro; and inhibit tumor growth in vivo.
摘要翻译: 公开了人源化和变异的抗VEGF抗体及其各种用途。 抗VEGF抗体对VEGF具有很强的结合亲和力; 体外抑制VEGF诱导的内皮细胞增殖; 并在体内抑制肿瘤生长。
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公开(公告)号:US07060269B1
公开(公告)日:2006-06-13
申请号:US09723752
申请日:2000-11-27
IPC分类号: A61K39/395
CPC分类号: C07K16/22 , A61K38/00 , C07K16/005 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/569 , C07K2317/73 , C07K2317/92
摘要: Humanized and variant anti-VEGF antibodies and various uses therefor are disclosed. The anti-VEGF antibodies have strong binding affinities for VEGF; inhibit VEGF-induced proliferation of endothelial cells in vitro; and inhibit tumor growth in vivo.
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公开(公告)号:US20080226629A1
公开(公告)日:2008-09-18
申请号:US12056724
申请日:2008-03-27
IPC分类号: A61K31/395 , C07K16/22
CPC分类号: C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/92
摘要: Humanized and variant anti-VEGF antibodies and various uses therefor are disclosed. The anti-VEGF antibodies have strong binding affinities for VEGF; inhibit VEGF-induced proliferation of endothelial cells in vitro; and inhibit tumor growth in vivo.
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公开(公告)号:US07297334B2
公开(公告)日:2007-11-20
申请号:US10974591
申请日:2004-10-26
IPC分类号: A61K39/395
CPC分类号: C07K16/22 , A61K38/00 , C07K16/005 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/569 , C07K2317/73 , C07K2317/92
摘要: Humanized and variant anti-VEGF antibodies and various uses therefor are disclosed. The anti-VEGF antibodies have strong binding affinities for VEGF; inhibit VEGF-induced proliferation of endothelial cells in vitro; and inhibit tumor growth in vivo.
摘要翻译: 公开了人源化和变异的抗VEGF抗体及其各种用途。 抗VEGF抗体对VEGF具有很强的结合亲和力; 体外抑制VEGF诱导的内皮细胞增殖; 并在体内抑制肿瘤生长。
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公开(公告)号:US07169901B2
公开(公告)日:2007-01-30
申请号:US10234671
申请日:2002-09-03
IPC分类号: C07K16/00
CPC分类号: C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/92
摘要: Humanized and variant anti-VEGF antibodies and various uses therefor are disclosed. The anti-VEGF antibodies have strong binding affinities for VEGF; inhibit VEGF-induced proliferation of endothelial cells in vitro; and inhibit tumor growth in vivo.
摘要翻译: 公开了人源化和变异的抗VEGF抗体及其各种用途。 抗VEGF抗体对VEGF具有很强的结合亲和力; 体外抑制VEGF诱导的内皮细胞增殖; 并在体内抑制肿瘤生长。
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公开(公告)号:US06608028B1
公开(公告)日:2003-08-19
申请号:US09723251
申请日:2000-11-27
申请人: Yvonne Man-yee Chen , Ross G. Clark , Andrea G. Cochran , Henry B. Lowman , Iain C. A. F. Robinson , Nicholas J. Skelton
发明人: Yvonne Man-yee Chen , Ross G. Clark , Andrea G. Cochran , Henry B. Lowman , Iain C. A. F. Robinson , Nicholas J. Skelton
IPC分类号: A61K3810
CPC分类号: C07K7/08 , A61K38/30 , C07K14/4743 , C07K14/65 , C07K2319/00 , Y10S930/12 , Y10S930/26 , Y10S930/27 , A61K2300/00
摘要: Peptides are provided that inhibit the interaction of an IGF with any one of its binding proteins and not to a human IGF receptor. These IGF agonist peptides are useful to increase serum and tissue levels of active IGFs in a mammal.
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公开(公告)号:US06420518B1
公开(公告)日:2002-07-16
申请号:US09337227
申请日:1999-06-22
申请人: Yvonne Man-yee Chen , Ross G. Clark , Andrea G. Cochran , Henry B. Lowman , Iain C. A. F. Robinson , Nicholas J. Skelton
发明人: Yvonne Man-yee Chen , Ross G. Clark , Andrea G. Cochran , Henry B. Lowman , Iain C. A. F. Robinson , Nicholas J. Skelton
IPC分类号: C07K764
CPC分类号: C07K7/08 , A61K38/30 , C07K14/4743 , C07K14/65 , C07K2319/00 , Y10S930/12 , Y10S930/26 , Y10S930/27 , A61K2300/00
摘要: Peptides are provided that inhibit the interaction of an IGF with any one of its binding proteins and not to a human IGF receptor. These IGF agonist peptides are useful to increase serum and tissue levels of active IGFs in a mammal.
摘要翻译: 提供了抑制IGF与其任何一种结合蛋白而不是人IGF受体的相互作用的肽。 这些IGF激动剂肽可用于增加哺乳动物中活性IGF的血清和组织水平。
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公开(公告)号:US06750321B1
公开(公告)日:2004-06-15
申请号:US09723185
申请日:2000-11-27
申请人: Yvonne Man-yee Chen , Ross G. Clark , Andrea G. Cochran , Henry B. Lowman , Iain C. A. F. Robinson , Nicolas J. Skelton
发明人: Yvonne Man-yee Chen , Ross G. Clark , Andrea G. Cochran , Henry B. Lowman , Iain C. A. F. Robinson , Nicolas J. Skelton
IPC分类号: C07K750
CPC分类号: C07K7/08 , A61K38/00 , A61K38/30 , C07K14/4743 , C07K14/65 , C07K2319/00 , Y10S930/27 , A61K2300/00
摘要: Peptides are provided that inhibit the interaction of an IGF with any one of its binding proteins and not to a human IGF receptor. These IGF agonist peptides are useful to increase serum and tissue levels of active IGFs in a mammal.
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公开(公告)号:US06743894B1
公开(公告)日:2004-06-01
申请号:US09723254
申请日:2000-11-27
申请人: Yvonne Man-yee Chen , Ross G. Clark , Andrea G. Cochran , Henry B. Lowman , Iain C. A. F Robinson , Nicholas J. Skelton
发明人: Yvonne Man-yee Chen , Ross G. Clark , Andrea G. Cochran , Henry B. Lowman , Iain C. A. F Robinson , Nicholas J. Skelton
IPC分类号: C07K754
CPC分类号: C07K7/08 , A61K38/00 , A61K38/30 , C07K14/4743 , C07K14/65 , C07K2319/00 , Y10S930/27 , A61K2300/00
摘要: Peptides are provided that inhibit the interaction of an IGF with any one of its binding proteins and not to a human IGF receptor. These IGF agonist peptides are useful to increase serum and tissue levels of active IGFs in a mammal.
摘要翻译: 提供了抑制IGF与其任何一种结合蛋白而不是人IGF受体的相互作用的肽。 这些IGF激动剂肽可用于增加哺乳动物中活性IGF的血清和组织水平。
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