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公开(公告)号：US07375193B2
公开(公告)日：2008-05-20
申请号：US11537015
申请日：2006-09-29
IPC分类号： C07K16/00
CPC分类号： C07K16/22 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Humanized and variant anti-VEGF antibodies and various uses therefor are disclosed. The anti-VEGF antibodies have strong binding affinities for VEGF; inhibit VEGF-induced proliferation of endothelial cells in vitro; and inhibit tumor growth in vivo.
摘要翻译： 公开了人源化和变异的抗VEGF抗体及其各种用途。 抗VEGF抗体对VEGF具有很强的结合亲和力; 体外抑制VEGF诱导的内皮细胞增殖; 并在体内抑制肿瘤生长。
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公开(公告)号：US20080226629A1
公开(公告)日：2008-09-18
申请号：US12056724
申请日：2008-03-27
IPC分类号： A61K31/395 , C07K16/22
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/92
摘要： Humanized and variant anti-VEGF antibodies and various uses therefor are disclosed. The anti-VEGF antibodies have strong binding affinities for VEGF; inhibit VEGF-induced proliferation of endothelial cells in vitro; and inhibit tumor growth in vivo.
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公开(公告)号：US20080187534A1
公开(公告)日：2008-08-07
申请号：US12021232
申请日：2008-01-28
CPC分类号： C07K16/22 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Humanized and variant anti-VEGF antibodies and various uses therefor are disclosed. The anti-VEGF antibodies have strong binding affinities for VEGF; inhibit VEGF-induced proliferation of endothelial cells in vitro; and inhibit tumor growth in vivo.
摘要翻译： 公开了人源化和变异的抗VEGF抗体及其各种用途。 抗VEGF抗体对VEGF具有很强的结合亲和力; 体外抑制VEGF诱导的内皮细胞增殖; 并在体内抑制肿瘤生长。
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公开(公告)号：US07365166B2
公开(公告)日：2008-04-29
申请号：US11536603
申请日：2006-09-28
IPC分类号： C07K16/00
CPC分类号： C07K16/22 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Humanized and variant anti-VEGF antibodies and various uses therefor are disclosed. The anti-VEGF antibodies have strong binding affinities for VEGF; inhibit VEGF-induced proliferation of endothelial cells in vitro; and inhibit tumor growth in vivo.
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公开(公告)号：US07297334B2
公开(公告)日：2007-11-20
申请号：US10974591
申请日：2004-10-26
IPC分类号： A61K39/395
CPC分类号： C07K16/22 , A61K38/00 , C07K16/005 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/569 , C07K2317/73 , C07K2317/92
摘要： Humanized and variant anti-VEGF antibodies and various uses therefor are disclosed. The anti-VEGF antibodies have strong binding affinities for VEGF; inhibit VEGF-induced proliferation of endothelial cells in vitro; and inhibit tumor growth in vivo.
摘要翻译： 公开了人源化和变异的抗VEGF抗体及其各种用途。 抗VEGF抗体对VEGF具有很强的结合亲和力; 体外抑制VEGF诱导的内皮细胞增殖; 并在体内抑制肿瘤生长。
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公开(公告)号：US07169901B2
公开(公告)日：2007-01-30
申请号：US10234671
申请日：2002-09-03
IPC分类号： C07K16/00
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/92
摘要： Humanized and variant anti-VEGF antibodies and various uses therefor are disclosed. The anti-VEGF antibodies have strong binding affinities for VEGF; inhibit VEGF-induced proliferation of endothelial cells in vitro; and inhibit tumor growth in vivo.
摘要翻译： 公开了人源化和变异的抗VEGF抗体及其各种用途。 抗VEGF抗体对VEGF具有很强的结合亲和力; 体外抑制VEGF诱导的内皮细胞增殖; 并在体内抑制肿瘤生长。
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公开(公告)号：US20110052575A1
公开(公告)日：2011-03-03
申请号：US12768089
申请日：2010-04-27
IPC分类号： A61K39/395 , C07K16/22 , A61P35/00
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/92
摘要： Humanized and variant anti-VEGF antibodies and various uses therefor are disclosed. The anti-VEGF antibodies have strong binding affinities for VEGF; inhibit VEGF-induced proliferation of endothelial cells in vitro; and inhibit tumor growth in vivo.
摘要翻译： 公开了人源化和变异的抗VEGF抗体及其各种用途。 抗VEGF抗体对VEGF具有很强的结合亲和力; 体外抑制VEGF诱导的内皮细胞增殖; 并在体内抑制肿瘤生长。
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公开(公告)号：US07060269B1
公开(公告)日：2006-06-13
申请号：US09723752
申请日：2000-11-27
IPC分类号： A61K39/395
CPC分类号： C07K16/22 , A61K38/00 , C07K16/005 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/569 , C07K2317/73 , C07K2317/92
摘要： Humanized and variant anti-VEGF antibodies and various uses therefor are disclosed. The anti-VEGF antibodies have strong binding affinities for VEGF; inhibit VEGF-induced proliferation of endothelial cells in vitro; and inhibit tumor growth in vivo.
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公开(公告)号：US07799900B2
公开(公告)日：2010-09-21
申请号：US11147780
申请日：2005-06-07
申请人： Camellia W. Adams , Andrew C. Chan , Craig W. Crowley , Henry B. Lowman , Gerald R. Nakamura , Leonard G. Presta
发明人： Camellia W. Adams , Andrew C. Chan , Craig W. Crowley , Henry B. Lowman , Gerald R. Nakamura , Leonard G. Presta
IPC分类号： C12P21/08
CPC分类号： C07K16/2887 , A61K2039/505 , C07K2317/24 , C07K2317/41 , C07K2317/52 , C07K2317/522 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/75 , C07K2317/92
摘要： The invention provides humanized and chimeric anti-CD20 antibodies for treatment of CD20 positive malignancies and autoimmune diseases.
摘要翻译： 本发明提供用于治疗CD20阳性恶性肿瘤和自身免疫疾病的人源化和嵌合抗CD20抗体。
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公开(公告)号：US07157085B2
公开(公告)日：2007-01-02
申请号：US10791619
申请日：2004-03-02
IPC分类号： A61K39/395
CPC分类号： C07K16/4291 , A61K39/39566 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , A61K2300/00
摘要： The present invention relates to a method for adjusting the affinity of a polypeptide to a target molecule by a combination of steps, including: (1) the identification of aspartyl residues which are prone to isomerization; (2) the substitution of alternative residues and screening the resulting mutants for affinity against the target molecule. In a preferred embodiment, the method of subtituting residues is affinity maturation with phage display (AMPD). In a further preferred embodiment the polypeptide is an antibody and the target molecule is an antigen. In a further preferred embodiment, the antibody is anti-IgE and the target molecule is IgE. In another embodiment, the invention relates to an anti-IgE antibody having improved affinity to IgE.
摘要翻译： 本发明涉及通过以下步骤的组合来调节多肽与靶分子的亲和力的方法，包括：（1）鉴定易于异构化的天冬氨酰残基; （2）替代替代残基并筛选得到的突变体对靶分子的亲合力。 在优选的实施方案中，残基残基的方法是用噬菌体展示（AMPD）进行亲和力成熟。 在另一优选实施方案中，多肽是抗体，靶分子是抗原。 在另一个优选的实施方案中，抗体是抗IgE，靶分子是IgE。 在另一个实施方案中，本发明涉及对IgE具有改善的亲和力的抗IgE抗体。
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