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公开(公告)号:US07375193B2
公开(公告)日:2008-05-20
申请号:US11537015
申请日:2006-09-29
IPC分类号: C07K16/00
CPC分类号: C07K16/22 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要: Humanized and variant anti-VEGF antibodies and various uses therefor are disclosed. The anti-VEGF antibodies have strong binding affinities for VEGF; inhibit VEGF-induced proliferation of endothelial cells in vitro; and inhibit tumor growth in vivo.
摘要翻译: 公开了人源化和变异的抗VEGF抗体及其各种用途。 抗VEGF抗体对VEGF具有很强的结合亲和力; 体外抑制VEGF诱导的内皮细胞增殖; 并在体内抑制肿瘤生长。
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公开(公告)号:US20110052575A1
公开(公告)日:2011-03-03
申请号:US12768089
申请日:2010-04-27
IPC分类号: A61K39/395 , C07K16/22 , A61P35/00
CPC分类号: C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/92
摘要: Humanized and variant anti-VEGF antibodies and various uses therefor are disclosed. The anti-VEGF antibodies have strong binding affinities for VEGF; inhibit VEGF-induced proliferation of endothelial cells in vitro; and inhibit tumor growth in vivo.
摘要翻译: 公开了人源化和变异的抗VEGF抗体及其各种用途。 抗VEGF抗体对VEGF具有很强的结合亲和力; 体外抑制VEGF诱导的内皮细胞增殖; 并在体内抑制肿瘤生长。
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公开(公告)号:US20080226629A1
公开(公告)日:2008-09-18
申请号:US12056724
申请日:2008-03-27
IPC分类号: A61K31/395 , C07K16/22
CPC分类号: C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/92
摘要: Humanized and variant anti-VEGF antibodies and various uses therefor are disclosed. The anti-VEGF antibodies have strong binding affinities for VEGF; inhibit VEGF-induced proliferation of endothelial cells in vitro; and inhibit tumor growth in vivo.
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公开(公告)号:US20080187534A1
公开(公告)日:2008-08-07
申请号:US12021232
申请日:2008-01-28
CPC分类号: C07K16/22 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要: Humanized and variant anti-VEGF antibodies and various uses therefor are disclosed. The anti-VEGF antibodies have strong binding affinities for VEGF; inhibit VEGF-induced proliferation of endothelial cells in vitro; and inhibit tumor growth in vivo.
摘要翻译: 公开了人源化和变异的抗VEGF抗体及其各种用途。 抗VEGF抗体对VEGF具有很强的结合亲和力; 体外抑制VEGF诱导的内皮细胞增殖; 并在体内抑制肿瘤生长。
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公开(公告)号:US07365166B2
公开(公告)日:2008-04-29
申请号:US11536603
申请日:2006-09-28
IPC分类号: C07K16/00
CPC分类号: C07K16/22 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要: Humanized and variant anti-VEGF antibodies and various uses therefor are disclosed. The anti-VEGF antibodies have strong binding affinities for VEGF; inhibit VEGF-induced proliferation of endothelial cells in vitro; and inhibit tumor growth in vivo.
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公开(公告)号:US07297334B2
公开(公告)日:2007-11-20
申请号:US10974591
申请日:2004-10-26
IPC分类号: A61K39/395
CPC分类号: C07K16/22 , A61K38/00 , C07K16/005 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/569 , C07K2317/73 , C07K2317/92
摘要: Humanized and variant anti-VEGF antibodies and various uses therefor are disclosed. The anti-VEGF antibodies have strong binding affinities for VEGF; inhibit VEGF-induced proliferation of endothelial cells in vitro; and inhibit tumor growth in vivo.
摘要翻译: 公开了人源化和变异的抗VEGF抗体及其各种用途。 抗VEGF抗体对VEGF具有很强的结合亲和力; 体外抑制VEGF诱导的内皮细胞增殖; 并在体内抑制肿瘤生长。
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公开(公告)号:US07169901B2
公开(公告)日:2007-01-30
申请号:US10234671
申请日:2002-09-03
IPC分类号: C07K16/00
CPC分类号: C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/92
摘要: Humanized and variant anti-VEGF antibodies and various uses therefor are disclosed. The anti-VEGF antibodies have strong binding affinities for VEGF; inhibit VEGF-induced proliferation of endothelial cells in vitro; and inhibit tumor growth in vivo.
摘要翻译: 公开了人源化和变异的抗VEGF抗体及其各种用途。 抗VEGF抗体对VEGF具有很强的结合亲和力; 体外抑制VEGF诱导的内皮细胞增殖; 并在体内抑制肿瘤生长。
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公开(公告)号:US07060269B1
公开(公告)日:2006-06-13
申请号:US09723752
申请日:2000-11-27
IPC分类号: A61K39/395
CPC分类号: C07K16/22 , A61K38/00 , C07K16/005 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/569 , C07K2317/73 , C07K2317/92
摘要: Humanized and variant anti-VEGF antibodies and various uses therefor are disclosed. The anti-VEGF antibodies have strong binding affinities for VEGF; inhibit VEGF-induced proliferation of endothelial cells in vitro; and inhibit tumor growth in vivo.
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公开(公告)号:US08110548B2
公开(公告)日:2012-02-07
申请号:US11934582
申请日:2007-11-02
申请人: Yvonne Man-Yee Chen , Ross G. Clark , Andrea G. Cochran , Yves Dubaquie , Paul J. Fielder , Ellen Filvaroff , Henry B. Lowman , Deborah L. Mortensen , Iain C. A. F. Robinson , Nicholas J. Skelton
发明人: Yvonne Man-Yee Chen , Ross G. Clark , Andrea G. Cochran , Yves Dubaquie , Paul J. Fielder , Ellen Filvaroff , Henry B. Lowman , Deborah L. Mortensen , Iain C. A. F. Robinson , Nicholas J. Skelton
IPC分类号: A61K38/00
CPC分类号: C07K7/08 , A61K38/1709 , A61K38/30 , C07K14/4743 , C07K14/65 , C07K2319/00 , A61K2300/00
摘要: The present invention relates to a method for the treatment of a cartilage disorder, including cartilage damaged by injury or degenerative cartilagenous disorders. The method involves contacting the cartilage with an IGF-1 analog with altered affinity for IGF-binding proteins (IGFBPs) or an IGFBP displacer peptide that prevents the interaction of an IGF with an IGFBP and does not bind to a human IGF receptor.
摘要翻译: 本发明涉及一种治疗软骨障碍的方法,包括由损伤或退行性软骨疾病损伤的软骨。 该方法包括使软骨与IGF-1类似物接触,IGF-1类似物对IGF结合蛋白(IGFBPs)或IGFBP替代肽具有改变的亲和性,所述IGFBP置换肽阻止IGF与IGFBP的相互作用并且不结合人IGF受体。
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公开(公告)号:US06608028B1
公开(公告)日:2003-08-19
申请号:US09723251
申请日:2000-11-27
申请人: Yvonne Man-yee Chen , Ross G. Clark , Andrea G. Cochran , Henry B. Lowman , Iain C. A. F. Robinson , Nicholas J. Skelton
发明人: Yvonne Man-yee Chen , Ross G. Clark , Andrea G. Cochran , Henry B. Lowman , Iain C. A. F. Robinson , Nicholas J. Skelton
IPC分类号: A61K3810
CPC分类号: C07K7/08 , A61K38/30 , C07K14/4743 , C07K14/65 , C07K2319/00 , Y10S930/12 , Y10S930/26 , Y10S930/27 , A61K2300/00
摘要: Peptides are provided that inhibit the interaction of an IGF with any one of its binding proteins and not to a human IGF receptor. These IGF agonist peptides are useful to increase serum and tissue levels of active IGFs in a mammal.
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