发明申请
- 专利标题： HIGH AFFINITY VEGF-RECEPTOR ANTAGONISTS
- 专利标题（中）： 高亲和力VEGF受体拮抗剂
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申请号： US12950425申请日： 2010-11-19
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公开(公告)号： US20110077201A1公开(公告)日： 2011-03-31
- 发明人: Thomas Kodadek , D. Gomika Udugamasooriya , Rolf Brekken
- 申请人： Thomas Kodadek , D. Gomika Udugamasooriya , Rolf Brekken
- 主分类号： A61K38/08
- IPC分类号： A61K38/08 ; C12N5/071 ; C40B30/04 ; A61P35/00 ; A61P35/04 ; B82Y5/00
摘要：
A cell-based screen is reported can be used to identify specific receptor-binding compounds in a combinatorial library of peptoids (N-alkylglycine oligomers) displayed on beads. This strategy was applied to the isolation of Vascular Endothelial Growth Factor Receptor 2 (VEGFR2)-binding peptoids, which were optimized to create lead compounds with high affinity for VEGFR2. One of these peptoids was shown to be an antagonist of VEGF-VEGFR2 interaction and receptor function.
公开/授权文献
- US09233162B2 High affinity VEGF-receptor antagonists 公开/授权日：2016-01-12
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