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公开(公告)号：US08334239B2
公开(公告)日：2012-12-18
申请号：US12166042
申请日：2008-07-01
IPC分类号： C40B30/04
CPC分类号： A61K47/481 , A61K38/08 , A61K45/06 , A61K47/55 , A61K49/0043 , A61K2300/00
摘要： A cell-based screen is reported can be used to identify specific receptor-binding compounds in a combinatorial library of peptoids (N-alkylglycine oligomers) displayed on beads. This strategy was applied to the isolation of Vascular Endothelial Growth Factor Receptor 2 (VEGFR2)-binding peptoids, which were optimized to create lead compounds with high affinity for VEGFR2. One of these peptoids was shown to be an antagonist of VEGF-VEGFR2 interaction and receptor function.
摘要翻译： 据报道，基于细胞的筛选可以鉴定出显示在珠粒上的拟肽（N-烷基甘氨酸寡聚物）的组合文库中的特异性受体结合化合物。 该策略被应用于分离血管内皮生长因子受体2（VEGFR2）结合的拟肽，其被优化以产生对VEGFR2具有高亲和力的铅化合物。 这些拟肽中的一种被证明是VEGF-VEGFR2相互作用和受体功能的拮抗剂。
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公开(公告)号：US09233162B2
公开(公告)日：2016-01-12
申请号：US12950425
申请日：2010-11-19
IPC分类号： A61K38/08 , A61P35/00 , A61P35/04 , C12N5/071 , C40B30/04 , B82Y5/00 , A61K47/48 , A61K45/06 , A61K49/00
CPC分类号： A61K47/481 , A61K38/08 , A61K45/06 , A61K47/55 , A61K49/0043 , A61K2300/00
摘要： A cell-based screen is reported can be used to identify specific receptor-binding compounds in a combinatorial library of peptoids (N-alkylglycine oligomers) displayed on beads. This strategy was applied to the isolation of Vascular Endothelial Growth Factor Receptor 2 (VEGFR2)-binding peptoids, which were optimized to create lead compounds with high affinity for VEGFR2. One of these peptoids was shown to be an antagonist of VEGF-VEGFR2 interaction and receptor function.
摘要翻译： 据报道，基于细胞的筛选可以鉴定出显示在珠粒上的拟肽（N-烷基甘氨酸寡聚物）的组合文库中的特异性受体结合化合物。 该策略被应用于分离血管内皮生长因子受体2（VEGFR2）结合的拟肽，其被优化以产生对VEGFR2具有高亲和力的铅化合物。 这些拟肽中的一种被证明是VEGF-VEGFR2相互作用和受体功能的拮抗剂。
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公开(公告)号：US20110077201A1
公开(公告)日：2011-03-31
申请号：US12950425
申请日：2010-11-19
CPC分类号： A61K47/481 , A61K38/08 , A61K45/06 , A61K47/55 , A61K49/0043 , A61K2300/00
摘要： A cell-based screen is reported can be used to identify specific receptor-binding compounds in a combinatorial library of peptoids (N-alkylglycine oligomers) displayed on beads. This strategy was applied to the isolation of Vascular Endothelial Growth Factor Receptor 2 (VEGFR2)-binding peptoids, which were optimized to create lead compounds with high affinity for VEGFR2. One of these peptoids was shown to be an antagonist of VEGF-VEGFR2 interaction and receptor function.
摘要翻译： 据报道，基于细胞的筛选可以鉴定出显示在珠粒上的拟肽（N-烷基甘氨酸寡聚物）的组合文库中的特异性受体结合化合物。 该策略被应用于分离血管内皮生长因子受体2（VEGFR2）结合的拟肽，其被优化以产生对VEGFR2具有高亲和力的铅化合物。 这些拟肽中的一种被证明是VEGF-VEGFR2相互作用和受体功能的拮抗剂。
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4.发明申请公开(公告)号：US20100303835A1
公开(公告)日：2010-12-02
申请号：US12789711
申请日：2010-05-28
IPC分类号： A61K39/395 , G01N33/53 , C12N5/0783 , A61K35/12 , A61K35/14 , C07K2/00 , A61P37/00 , A61P37/06
CPC分类号： C07K7/06 , A61K49/0008 , A61M37/00 , G01N33/505
摘要： The present invention provides for the identification of autoreactive T cell populations from individuals having autoimmune diseases, such as multiple sclerosis and EAE. Peptoids recognized by autoreactive T cells can be used to identify various types of autoimmune disease, and can also be used to target therapies against such populations.
摘要翻译： 本发明提供从具有自身免疫疾病如多发性硬化和EAE的个体鉴定自身反应性T细胞群体。 由自身反应性T细胞识别的Pepto可用于鉴定各种类型的自身免疫疾病，并且也可用于靶向针对这些群体的治疗。
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公开(公告)号：US20090246124A1
公开(公告)日：2009-10-01
申请号：US12166042
申请日：2008-07-01
CPC分类号： A61K47/481 , A61K38/08 , A61K45/06 , A61K47/55 , A61K49/0043 , A61K2300/00
摘要： A cell-based screen is reported can be used to identify specific receptor-binding compounds in a combinatorial library of peptoids (N-alkylglycine oligomers) displayed on beads. This strategy was applied to the isolation of Vascular Endothelial Growth Factor Receptor 2 (VEGFR2)-binding peptoids, which were optimized to create lead compounds with high affinity for VEGFR2. One of these peptoids was shown to be an antagonist of VEGF-VEGFR2 interaction and receptor function.
摘要翻译： 据报道，基于细胞的筛选可以鉴定出显示在珠粒上的拟肽（N-烷基甘氨酸寡聚物）的组合文库中的特异性受体结合化合物。 该策略被应用于分离血管内皮生长因子受体2（VEGFR2）结合的拟肽，其被优化以产生对VEGFR2具有高亲和力的铅化合物。 这些拟肽中的一种被证明是VEGF-VEGFR2相互作用和受体功能的拮抗剂。
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