发明申请
- 专利标题： HOMING IN MESENCHYMAL STEM CELLS
- 专利标题（中）： 在MESENCHYMAL STEM细胞中呼吸
-
申请号： US12921396申请日： 2009-03-06
-
公开(公告)号： US20110165128A1公开(公告)日： 2011-07-07
- 发明人: Sergey V. Doronin , Irina A. Potapova , Ira S. Cohen , Michael R. Rosen , Richard B. Robinson , Peter R. Brink
- 申请人： Sergey V. Doronin , Irina A. Potapova , Ira S. Cohen , Michael R. Rosen , Richard B. Robinson , Peter R. Brink
- 申请人地址： US NY New York City
- 专利权人： Columbia University in the City of New York
- 当前专利权人： Columbia University in the City of New York
- 当前专利权人地址： US NY New York City
- 国际申请： PCT/US09/36414 WO 20090306
- 主分类号： A61K35/12
- IPC分类号： A61K35/12 ; C12N5/0775 ; A61P9/00 ; A61P9/10
摘要：
The present invention relates to expression of CXCR4 in mesenchymal stem cells (MSCs) and homing of MSCs to sites of injury. In particular, the invention provides expanded cultures of MSCs which maintain cell surface expression of CXCR4. The MSCs are capable of homing to sites of injury and are suitable for treatment of ischemic disorders, including cardiac disorders, bone and cartilage disorders, liver disorders, inflammatory disorders, and stroke.
信息查询
