发明申请
- 专利标题： Methods for Diagnosis, Prognosis and Methods of Treatment
- 专利标题（中）： 诊断方法，预后及治疗方法
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申请号： US13083156申请日： 2011-04-08
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公开(公告)号： US20110269154A1公开(公告)日： 2011-11-03
- 发明人: Wendy J. FANTL , David B. Rosen , Alessandra Cesano , Santosh K. Putta , James R. Hackett , Michael Walker , Jing Shi
- 申请人： Wendy J. FANTL , David B. Rosen , Alessandra Cesano , Santosh K. Putta , James R. Hackett , Michael Walker , Jing Shi
- 申请人地址： US CA South San Francisco
- 专利权人： Nodality, Inc.
- 当前专利权人： Nodality, Inc.
- 当前专利权人地址： US CA South San Francisco
- 主分类号： G01N33/567
- IPC分类号： G01N33/567 ; G01N33/574
摘要：
The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN.
公开/授权文献
- US08273544B2 Methods for diagnosis, prognosis and methods of treatment 公开/授权日：2012-09-25
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