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公开(公告)号：US08399206B2
公开(公告)日：2013-03-19
申请号：US12910769
申请日：2010-10-22
Applicant: Wendy J. Fantl , David B. Rosen , Alessandra Cesano , Santosh K. Putta , James R. Hackett , Michael Walker , Jing Shi
Inventor： Wendy J. Fantl , David B. Rosen , Alessandra Cesano , Santosh K. Putta , James R. Hackett , Michael Walker , Jing Shi
IPC: G01N33/53 , G01N33/567 , G01N33/00
CPC classification number: G01N33/57426 , A61K31/4709 , A61K31/513 , A61K31/704 , A61K31/7068 , A61K31/7076 , G01N33/50 , G01N33/5041 , G01N33/5044 , G01N33/5047 , G01N33/5055 , G01N33/5073 , G01N33/5094 , G01N33/53 , G01N33/574 , G01N33/57407 , G01N33/6893 , G01N2333/705 , G01N2800/22 , G01N2800/52
Abstract: The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN.
Abstract translation: 本发明提供了用于确定单细胞中多种蛋白质的活化状态的方法。 这种方法允许基于活化状态，表达标志物和其他标准快速检测复杂细胞群体中的异质性，以及在细胞群体内表现出相关的激活变化的细胞亚群的鉴定。 此外，这种方法允许细胞活动或性质的相关性。 此外，使用细胞激活的调节剂允许表征途径和细胞群体。 可以使用本发明分析的几种示例性疾病包括AML，MDS和MPN。
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Patent Agency Ranking
公开(公告)号：US20110104717A1
公开(公告)日：2011-05-05
申请号：US12910769
申请日：2010-10-22
Applicant: Wendy J. Fantl , David B. Rosen , Alessandra Cesano , Santosh K. Putta , James R. Hackett , Michael Walker , Jing Shi
Inventor： Wendy J. Fantl , David B. Rosen , Alessandra Cesano , Santosh K. Putta , James R. Hackett , Michael Walker , Jing Shi
IPC: G01N33/53
CPC classification number: G01N33/57426 , A61K31/4709 , A61K31/513 , A61K31/704 , A61K31/7068 , A61K31/7076 , G01N33/50 , G01N33/5041 , G01N33/5044 , G01N33/5047 , G01N33/5055 , G01N33/5073 , G01N33/5094 , G01N33/53 , G01N33/574 , G01N33/57407 , G01N33/6893 , G01N2333/705 , G01N2800/22 , G01N2800/52
Abstract: The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN.
Abstract translation: 本发明提供了用于确定单细胞中多种蛋白质的活化状态的方法。 这种方法允许基于活化状态，表达标志物和其他标准快速检测复杂细胞群体中的异质性，以及在细胞群体内表现出相关的激活变化的细胞亚群的鉴定。 此外，这种方法允许细胞活动或性质的相关性。 此外，使用细胞激活的调节剂允许表征途径和细胞群体。 可以使用本发明分析的几种示例性疾病包括AML，MDS和MPN。
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公开(公告)号：US20130034862A1
公开(公告)日：2013-02-07
申请号：US13596579
申请日：2012-08-28
Applicant: Wendy J. Fantl , David B. Rosen , Alessandra Cesano , Santosh K. Putta , James R. Hackett , Michael Walker , Jing Shi
Inventor： Wendy J. Fantl , David B. Rosen , Alessandra Cesano , Santosh K. Putta , James R. Hackett , Michael Walker , Jing Shi
CPC classification number: G01N33/57426 , A61K31/4709 , A61K31/513 , A61K31/704 , A61K31/7068 , A61K31/7076 , G01N33/50 , G01N33/5041 , G01N33/5044 , G01N33/5047 , G01N33/5055 , G01N33/5073 , G01N33/5094 , G01N33/53 , G01N33/574 , G01N33/57407 , G01N33/6893 , G01N2333/705 , G01N2800/22 , G01N2800/52
Abstract: The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN.
Abstract translation: 本发明提供了用于确定单细胞中多种蛋白质的活化状态的方法。 这种方法允许基于活化状态，表达标志物和其他标准快速检测复杂细胞群体中的异质性，以及在细胞群体内表现出相关的激活变化的细胞亚群的鉴定。 此外，这种方法允许细胞活动或性质的相关性。 此外，使用细胞激活的调节剂允许表征途径和细胞群体。 可以使用本发明分析的几种示例性疾病包括AML，MDS和MPN。
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公开(公告)号：US08273544B2
公开(公告)日：2012-09-25
申请号：US13083156
申请日：2011-04-08
Applicant: Wendy J. Fantl , David B. Rosen , Alessandra Cesano , Santosh K. Putta , James R. Hackett , Michael Walker , Jing Shi
Inventor： Wendy J. Fantl , David B. Rosen , Alessandra Cesano , Santosh K. Putta , James R. Hackett , Michael Walker , Jing Shi
IPC: G01N33/53 , G01N33/567 , G01N33/00
CPC classification number: G01N33/57426 , A61K31/4709 , A61K31/513 , A61K31/704 , A61K31/7068 , A61K31/7076 , G01N33/50 , G01N33/5041 , G01N33/5044 , G01N33/5047 , G01N33/5055 , G01N33/5073 , G01N33/5094 , G01N33/53 , G01N33/574 , G01N33/57407 , G01N33/6893 , G01N2333/705 , G01N2800/22 , G01N2800/52
Abstract: The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN.
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公开(公告)号：US20110269154A1
公开(公告)日：2011-11-03
申请号：US13083156
申请日：2011-04-08
Applicant: Wendy J. FANTL , David B. Rosen , Alessandra Cesano , Santosh K. Putta , James R. Hackett , Michael Walker , Jing Shi
Inventor： Wendy J. FANTL , David B. Rosen , Alessandra Cesano , Santosh K. Putta , James R. Hackett , Michael Walker , Jing Shi
IPC: G01N33/567 , G01N33/574
CPC classification number: G01N33/57426 , A61K31/4709 , A61K31/513 , A61K31/704 , A61K31/7068 , A61K31/7076 , G01N33/50 , G01N33/5041 , G01N33/5044 , G01N33/5047 , G01N33/5055 , G01N33/5073 , G01N33/5094 , G01N33/53 , G01N33/574 , G01N33/57407 , G01N33/6893 , G01N2333/705 , G01N2800/22 , G01N2800/52
Abstract: The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN.
Abstract translation: 本发明提供了用于确定单细胞中多种蛋白质的活化状态的方法。 这种方法允许基于活化状态，表达标志物和其他标准快速检测复杂细胞群体中的异质性，以及在细胞群体内表现出相关的激活变化的细胞亚群的鉴定。 此外，这种方法允许细胞活动或性质的相关性。 此外，使用细胞激活的调节剂允许表征途径和细胞群体。 可以使用本发明分析的几种示例性疾病包括AML，MDS和MPN。
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公开(公告)号：USD282917S
公开(公告)日：1986-03-11
申请号：US511777
申请日：1983-07-07
Applicant: James R. Hackett
Designer： James R. Hackett
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