发明申请
US20120009669A1 BIFUNCTIONAL COMPOUND WITH MONOSACCHARIDE AND N2S2 LIGAND, AND PREPARATION AND USE THEREOF
有权
具有单糖和N2S2配体的双功能化合物，其制备和使用
- 专利标题： BIFUNCTIONAL COMPOUND WITH MONOSACCHARIDE AND N2S2 LIGAND, AND PREPARATION AND USE THEREOF
- 专利标题（中）： 具有单糖和N2S2配体的双功能化合物，其制备和使用
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申请号： US13087664申请日： 2011-04-15
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公开(公告)号： US20120009669A1公开(公告)日： 2012-01-12
- 发明人: SHOW-WEN LIU , CHENG-HSIEN LIN , YU CHANG , CHENG-FANG HSU , TSYH-LANG LIN
- 申请人： SHOW-WEN LIU , CHENG-HSIEN LIN , YU CHANG , CHENG-FANG HSU , TSYH-LANG LIN
- 申请人地址： TW Taoyuan County
- 专利权人： Institute of Nuclear Energy Research Atomic Energy Council, Executive Yuan
- 当前专利权人： Institute of Nuclear Energy Research Atomic Energy Council, Executive Yuan
- 当前专利权人地址： TW Taoyuan County
- 优先权： TW099122659 20100709
- 主分类号： C07H15/04
- IPC分类号： C07H15/04 ; C12N5/071 ; C07K14/00
摘要：
A bifunctional compound with a monosaccharide and a N2S2 ligand, and more particularly, a bifunctional compound with a N2S2 ligand and aminohexylacetyl galactosamine (ah-GalNAc4) is provided. A method for preparing the bifunctional compound with a monosaccharide and a N2S2 ligand is also provided, including activating a carboxyl group in an organic ligand, reacting the activated carboxyl group with a galactopyranoside through amidation, and then hydrolyzing. The bifunctional compound of the present invention is widely useful in nuclear medicine for preparation of liver imaging agents for assisting in correct diagnosis of diseases.