Bifunctional compound with monosaccharide and N2S2 ligand, and preparation and use thereof
    2.
    发明授权
    Bifunctional compound with monosaccharide and N2S2 ligand, and preparation and use thereof 有权
    双官能化合物与单糖和N2S2配体,及其制备和应用

    公开(公告)号:US08551447B2

    公开(公告)日:2013-10-08

    申请号:US13087664

    申请日:2011-04-15

    IPC分类号: A61K38/00

    CPC分类号: C07H15/04

    摘要: A bifunctional compound with a monosaccharide and a N2S2 ligand, and more particularly, a bifunctional compound with a N2S2 ligand and aminohexylacetyl galactosamine (ah-GalNAc4) is provided. A method for preparing the bifunctional compound with a monosaccharide and a N2S2 ligand is also provided, including activating a carboxyl group in an organic ligand, reacting the activated carboxyl group with a galactopyranoside through amidation, and then hydrolyzing. The bifunctional compound of the present invention is widely useful in nuclear medicine for preparation of liver imaging agents for assisting in correct diagnosis of diseases.

    摘要翻译: 提供了具有单糖和N2S2配体的双官能化合物,更具体地,提供了具有N 2 S 2配体和氨基己基乙酰基半乳糖胺(ah-GalNAc 4)的双官能化合物。 还提供了用单糖和N 2 S 2配体制备双功能化合物的方法,包括活化有机配体中的羧基,通过酰胺化使活化的羧基与吡喃半乳糖苷反应,然后水解。 本发明的双功能化合物在制备用于辅助正确诊断疾病的肝成像剂的核医学中广泛有用。

    Apparatus for spraying etchant onto printed circuit board
    3.
    发明授权
    Apparatus for spraying etchant onto printed circuit board 有权
    用于在印刷电路板上喷涂蚀刻剂的装置

    公开(公告)号:US08377252B2

    公开(公告)日:2013-02-19

    申请号:US11614362

    申请日:2006-12-21

    IPC分类号: H01B13/00 B44C1/22 C23F1/00

    摘要: The present invention relates to an apparatus for spraying an etchant and a method for manufacturing a printed circuit board. In one exemplary embodiment the apparatus includes a manifold, a plurality of feed pipes in fluid communication with the manifold, each of the feed pipes having a plurality of spray nozzles mounted thereon, the feed pipes cooperatively constitute a spray region, and a pressure-boosting device configured for increasing a spray pressure of the spray nozzles which are located at a central area of the spray region. The apparatus can overcome “the puddle effect” on an upper surface of the printed circuit board.

    摘要翻译: 本发明涉及喷涂蚀刻剂的设备和印刷电路板的制造方法。 在一个示例性实施例中,设备包括歧管,与歧管流体连通的多个进料管,每个进料管具有安装在其上的多个喷嘴,进料管协同地构成喷射区域,并且加压 该装置被配置为增加位于喷射区域的中心区域处的喷嘴的喷雾压力。 该装置可以克服印刷电路板的上表面上的水坑效应。

    H3LMN compound used as radioactive agent for treatment of liver cancer and manufacturing method thereof
    4.
    发明授权
    H3LMN compound used as radioactive agent for treatment of liver cancer and manufacturing method thereof 有权
    用作肝癌放射性药物的H3LMN化合物及其制造方法

    公开(公告)号:US08329879B2

    公开(公告)日:2012-12-11

    申请号:US12558911

    申请日:2009-09-14

    IPC分类号: C07F13/00

    CPC分类号: C07C323/41 C07F13/005

    摘要: H3LMN series compounds used as radioactive agents for treatment of liver cancer and a manufacturing method thereof are revealed. 2-thioethylamine hydrochloride is reacted with triphenylmethanol for protection of thiol to obtain 2-[(triphenylmethyl)thio]ethylamine. Then obtain N-[2-((triphenylmethyl)thio)ethyl]chloroacetamide by a transamidation reaction between 2-[(triphenylmethyl)thio]ethylamine and chloroactyl chloride. Next produce a amine-amide-thiol ligand-N-[2-((triphenylmethyl)thio)ethyl][2-((triphenylmethyl)thio)ethylamino]acetamide by a substitution reaction of N-[2-((triphenylmethyl)thio)ethyl]chloroacetamide and 2-[(triphenylmethyl)thio]ethylamine. After respective reaction with 1-bromotetradecane, 1-bromohexadecane and ethyl 16-bromohexadecanoate, H3LMN series compounds are obtained. These amine-amide-dithiols quadridentate ligands can react with MO3+ (M=Tc or Re) to produce electrically neutral complexes. The complexes have high lipophilicity, allowing them soluble in lipiodol to be applied to radiation therapy for liver cancer.

    摘要翻译: 揭示了用作肝癌治疗放射剂的H3LMN系列化合物及其制造方法。 将2-硫代乙胺盐酸盐与三苯基甲醇反应以保护硫醇,得到2 - [(三苯基甲基)硫代]乙胺。 然后通过2 - [(三苯基甲基)硫代]乙胺和氯代酰氯的酰胺化反应获得N- [2 - ((三苯基甲基)硫基)乙基]氯乙酰胺。 接着通过N- [2 - ((三苯基甲基)硫代)的取代反应生成胺 - 酰胺 - 硫醇配体-N- [2 - ((三苯基甲基)硫代)乙基] [2 - ((三苯基甲基)硫基)乙基氨基] )乙基]氯乙酰胺和2 - [(三苯甲基)硫基]乙胺。 在与1-溴十四烷,1-溴十六烷和16-溴十六烷酸乙酯反应后,得到H3LMN系列化合物。 这些胺 - 酰胺 - 二硫醇三元配体可以与MO3 +(M = Tc或Re)反应以产生电中性络合物。 复合物具有高亲脂性,使其可溶于碘油以适用于放射治疗肝癌。

    Method for smoothing printed circuit boards
    6.
    发明授权
    Method for smoothing printed circuit boards 有权
    印刷电路板平滑方法

    公开(公告)号:US08227175B2

    公开(公告)日:2012-07-24

    申请号:US12467291

    申请日:2009-05-17

    IPC分类号: H05K3/00

    摘要: A method for smoothing a printed circuit board (PCB), comprising: providing a PCB having a first smooth outer surface and an opposite second outer surface, the second outer surface including a smooth region and a plurality of dimples; applying a liquid photoresist layer onto the second outer surface of the PCB to fill the dimples; solidifying the liquid photoresist in the dimples to obtain a solidified photoresist layer; polishing the solidified photoresist layer until a surface thereof being coplanar with the smooth region; and polishing the entire second outer surface until the solidified photoresist layer is removed, thereby obtaining a plain outer surface parallel to the first smooth outer surface.

    摘要翻译: 一种用于平滑印刷电路板(PCB)的方法,包括:提供具有第一光滑外表面和相对的第二外表面的PCB,所述第二外表面包括平滑区域和多个凹坑; 将液体光致抗蚀剂层施加到PCB的第二外表面上以填充凹坑; 在凹坑中固化液体光致抗蚀剂以获得固化的光致抗蚀剂层; 抛光固化的光致抗蚀剂层,直到其表面与光滑区域共面; 并且抛光整个第二外表面直到去除固化的光致抗蚀剂层,从而获得平行于第一光滑外表面的平原外表面。

    Multilayer printed circuit board
    7.
    发明授权
    Multilayer printed circuit board 有权
    多层印刷电路板

    公开(公告)号:US08101266B2

    公开(公告)日:2012-01-24

    申请号:US12135842

    申请日:2008-06-09

    IPC分类号: H01K1/00

    摘要: A multilayer printed circuit board includes a first printed circuit board, a second printed circuit board, an adhesive film, and a function layer. The adhesive film is sandwiched between the first printed circuit board and the second printed circuit board. The function layer is disposed between the first printed circuit board and the second printed circuit board for blocking water from passing therethrough and for screening electromagnetic interference between the first printed circuit board and the second printed circuit board.

    摘要翻译: 多层印刷电路板包括第一印刷电路板,第二印刷电路板,粘合膜和功能层。 粘合膜夹在第一印刷电路板和第二印刷电路板之间。 功能层设置在第一印刷电路板和第二印刷电路板之间,用于阻止水从其中通过,并用于屏蔽第一印刷电路板和第二印刷电路板之间的电磁干扰。

    Apparatus for recycling metal from metal ions containing waste solution
    9.
    发明授权
    Apparatus for recycling metal from metal ions containing waste solution 有权
    用于从含有废液的金属离子中回收金属的装置

    公开(公告)号:US08062580B2

    公开(公告)日:2011-11-22

    申请号:US12535909

    申请日:2009-08-05

    IPC分类号: C22B3/02

    摘要: An apparatus for recycling metals from metal ions containing waste solution includes a conveying device, a reducing agent supplier and a solution supplier. The conveying device includes a first ferromagnetic conveyor belt, a first roller, and a second roller. The first and second rollers are substantially horizontally arranged, and the second roller is arranged at a lower position relative to the first roller and spaced from the first roller. The ferromagnetic conveyor belt is wrapped around the first and second rollers. The reducing agent supplier is used for supplying a reducing agent onto the first conveyor belt, the ferromagnetic conveyor belt is capable of conveying the reducing agent from the second roller to the first roller. The solution supplier is configured for supplying the waste solution onto the first conveyor belt.

    摘要翻译: 用于从含金属离子的废液中回收金属的设备包括输送装置,还原剂供应商和溶液供应商。 输送装置包括第一铁磁输送带,第一辊和第二辊。 第一和第二辊基本上是水平布置的,并且第二辊布置在相对于第一辊子的下部位置并与第一辊子间隔开。 铁磁输送带缠绕在第一和第二辊子周围。 还原剂供应器用于将还原剂供应到第一传送带上,铁磁传送带能够将还原剂从第二辊输送到第一辊。 解决方案供应商被配置为将废溶液供应到第一传送带上。

    Radioactive mixture and manufacturing method thereof
    10.
    发明授权
    Radioactive mixture and manufacturing method thereof 有权
    放射性混合物及其制造方法

    公开(公告)号:US08048405B2

    公开(公告)日:2011-11-01

    申请号:US12354815

    申请日:2009-01-16

    IPC分类号: A61K49/00

    CPC分类号: A61K51/0478 A61K49/0438

    摘要: A radioactive mixture and a manufacturing method thereof are disclosed. The radioactive mixture (188Re-MN/Lipiodol mixture) is formed by chelating reaction of MN series compounds that are amine-amide-disulfide amine quadric-dentate chelate ligands with TcO4−/or ReO4−, and then dissolved in Lipiodol. Moreover, the 99mTc/or 188Re of the TcO4−/or ReO4− avoids bone marrow injuries caused by free 90Y. By the feature of the Lipiodol that stays in liver tumors for a long period, the radioactive mixture is applied to treat liver cancers by injection so that injuries caused by surgical operations can be prevented. 188Re-MN/Lipiodol is used for liver cancer, breast cancer or other solid tumors treatment. Re-188 MN or Re-188 MN/Lipiodol can be mixed with anticancer drugs, hydrogel, liposome, micelle or other nano-particles to form the multifunctional therapeutic modality.

    摘要翻译: 公开了放射性混合物及其制造方法。 通过胺胺 - 二硫化胺胺二齿螯合配体的MN系列化合物与TcO4-或ReO4-螯合反应形成放射性混合物(188Re-MN / Lipiodol混合物),然后溶于Lipiodol中。 此外,TcO4- /或ReO4的99mTc /或188Re避免了由自由90Y引起的骨髓损伤。 通过长时间停留在肝肿瘤中的碘碘醇的特征,通过注射施用放射性混合物来治疗肝癌,从而可以预防外科手术引起的损伤。 188Re-MN / Lipiodol用于肝癌,乳腺癌或其他实体瘤治疗。 Re-188 MN或Re-188 MN / Lipiodol可与抗癌药物,水凝胶,脂质体,胶束或其他纳米颗粒混合,形成多功能治疗方式。