发明申请
- 专利标题： IP-10 ANTIBODIES AND THEIR USES
- 专利标题（中）： IP-10抗体及其用途
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申请号： US13478786申请日： 2012-05-23
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公开(公告)号： US20120230998A1公开(公告)日： 2012-09-13
- 发明人: Shrikant DESHPANDE , Haichun HUANG , Mohan SRINIVASAN , Josephine M. CARDARELLI , Changyu WANG , David PASSMORE , Vangipuram RANGAN , Thomas E. LANE , Hans S. KEIRSTEAD , Michael T. LIU
- 申请人： Shrikant DESHPANDE , Haichun HUANG , Mohan SRINIVASAN , Josephine M. CARDARELLI , Changyu WANG , David PASSMORE , Vangipuram RANGAN , Thomas E. LANE , Hans S. KEIRSTEAD , Michael T. LIU
- 申请人地址： US NJ Princeton
- 专利权人： MEDAREX, INC.
- 当前专利权人： MEDAREX, INC.
- 当前专利权人地址： US NJ Princeton
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; A61P25/00 ; A61P19/02 ; A61P29/00 ; A61P1/00 ; A61P9/10 ; A61P17/00 ; A61P11/00 ; A61P25/28 ; A61K48/00 ; A61P13/12 ; C12N5/02 ; A61P3/10
摘要：
The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to IP-10 with high affinity, inhibit the binding of IP-10 to its receptor, inhibit IP-10-induced calcium flux and inhibit IP-10-induced cell migration. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting IP-10 activity using the antibodies of the invention, including methods for treating various inflammatory and autoimmune diseases.
公开/授权文献
- US08945546B2 IP-10 antibodies and their uses 公开/授权日：2015-02-03