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公开(公告)号：US08945546B2
公开(公告)日：2015-02-03
申请号：US13478786
申请日：2012-05-23
申请人： Shrikant Deshpande , Haichun Huang , Mohan Srinivasan , Josephine M. Cardarelli , Changyu Wang , David Passmore , Vangipuram Rangan , Thomas E. Lane , Hans S. Keirstead , Michael T. Liu
发明人： Shrikant Deshpande , Haichun Huang , Mohan Srinivasan , Josephine M. Cardarelli , Changyu Wang , David Passmore , Vangipuram Rangan , Thomas E. Lane , Hans S. Keirstead , Michael T. Liu
IPC分类号： A61K39/395 , A61K39/40 , C07K14/52 , C07K16/24 , A61K39/00
CPC分类号： C07K16/24 , A61K2039/505 , C07K14/522 , C07K2317/21 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要： The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to IP-10 with high affinity, inhibit the binding of IP-10 to its receptor, inhibit IP-10-induced calcium flux and inhibit IP-10-induced cell migration. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting IP-10 activity using the antibodies of the invention, including methods for treating various inflammatory and autoimmune diseases.
摘要翻译： 本发明提供以高亲和力结合IP-10的分离的单克隆抗体，特别是人抗体，抑制IP-10与其受体的结合，抑制IP-10诱导的钙通量并抑制IP-10诱导的细胞迁移 。 还提供了编码本发明抗体的核酸分子，表达载体，宿主细胞和用于表达本发明的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供了使用本发明的抗体来抑制IP-10活性的方法，包括治疗各种炎性和自身免疫性疾病的方法。
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2.发明授权Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury 有权衍生自人类胚胎干细胞的少突胶质细胞用于脊髓损伤的髓鞘再生和治疗公开(公告)号：US07579188B2
公开(公告)日：2009-08-25
申请号：US11637632
申请日：2006-12-11
CPC分类号： C12N5/0622 , A61K35/12 , C12N5/0623 , C12N2501/115 , C12N2501/395 , C12N2503/02 , C12N2506/02
摘要： This invention provides populations of neural cells bearing markers of glial cells, such as oligodendrocytes and their precursors. The populations are generated by differentiating pluripotent stem cells such as human embryonic stem cells under conditions that promote enrichment of cells with the desired phenotype or functional capability. Various combinations of differentiation factors and mitogens can be used to produce cell populations bearing markers of oligodendrocyte precursor cells. Upon further differentiation form complex processes characteristic of mature oligodendrocytes. The cells are capable of forming myelin sheaths, and can be used therapeutically improve function of the central nervous system.
摘要翻译： 本发明提供了具有神经胶质细胞标记物的神经细胞群体，例如少突胶质细胞及其前体。 通过在促进具有所需表型或功能能力的细胞富集的条件下分化多能干细胞例如人胚胎干细胞来产生群体。 分化因子和有丝分裂原的各种组合可用于产生具有少突胶质细胞前体细胞标志物的细胞群。 进一步分化形成成熟的少突胶质细胞特征的复杂过程。 细胞能够形成髓鞘，并且可以用于治疗性地改善中枢神经系统的功能。
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3.发明授权Immunological compositions and methods of use to transiently alter mammalian central nervous system myelin to promote neuronal regeneration 失效用于瞬时改变哺乳动物中枢神经系统髓鞘以促进神经元再生的免疫组合物和方法公开(公告)号：US06969516B1
公开(公告)日：2005-11-29
申请号：US09530234
申请日：1998-10-28
IPC分类号： A61K38/00 , A61K39/395 , A61P25/00 , A61P25/28 , A61P43/00 , A61K51/00 , C07K16/00 , C12N5/06
CPC分类号： A61K39/3955 , A61K2300/00
摘要： A method is described comprising the combined administration of a novel composition comprising serum complement proteins with complement-fixing antibodies to induce transient disruption of myelin and/or demyelination. The antibodies specifically bind to one or more epitopes of myelin, and complement proteins. A method is also described for promoting regrowth, repair, and regeneration of neurons in a mammalian subject. The methods can be used following immediate or chronic injury.
摘要翻译： 描述了一种方法，其包括将包含血清补体蛋白的新组合物与补体固定抗体组合施用以诱导髓磷脂的瞬时破坏和/或脱髓鞘。 抗体特异性结合髓鞘和补体蛋白的一个或多个表位。 还描述了一种用于促进哺乳动物受试者中神经元的再生长，修复和再生的方法。 这些方法可以在立即或慢性损伤后使用。
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公开(公告)号：US20120230998A1
公开(公告)日：2012-09-13
申请号：US13478786
申请日：2012-05-23
申请人： Shrikant DESHPANDE , Haichun HUANG , Mohan SRINIVASAN , Josephine M. CARDARELLI , Changyu WANG , David PASSMORE , Vangipuram RANGAN , Thomas E. LANE , Hans S. KEIRSTEAD , Michael T. LIU
发明人： Shrikant DESHPANDE , Haichun HUANG , Mohan SRINIVASAN , Josephine M. CARDARELLI , Changyu WANG , David PASSMORE , Vangipuram RANGAN , Thomas E. LANE , Hans S. KEIRSTEAD , Michael T. LIU
IPC分类号： A61K39/395 , A61P25/00 , A61P19/02 , A61P29/00 , A61P1/00 , A61P9/10 , A61P17/00 , A61P11/00 , A61P25/28 , A61K48/00 , A61P13/12 , C12N5/02 , A61P3/10
CPC分类号： C07K16/24 , A61K2039/505 , C07K14/522 , C07K2317/21 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要： The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to IP-10 with high affinity, inhibit the binding of IP-10 to its receptor, inhibit IP-10-induced calcium flux and inhibit IP-10-induced cell migration. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting IP-10 activity using the antibodies of the invention, including methods for treating various inflammatory and autoimmune diseases.
摘要翻译： 本发明提供以高亲和力结合IP-10的分离的单克隆抗体，特别是人抗体，抑制IP-10与其受体的结合，抑制IP-10诱导的钙通量并抑制IP-10诱导的细胞迁移 。 还提供了编码本发明抗体的核酸分子，表达载体，宿主细胞和用于表达本发明的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供了使用本发明的抗体来抑制IP-10活性的方法，包括治疗各种炎性和自身免疫性疾病的方法。
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公开(公告)号：US20100077497A1
公开(公告)日：2010-03-25
申请号：US12472877
申请日：2009-05-27
申请人： Shrikant DESHPANDE , Haichun HUANG , Mohan SRINIVASAN , Josephine M. CARDARELLI , Changyu WANG , David PASSMORE , Vangipuram RANGAN , Thomas E. LANE , Hans S. KEIRSTEAD , Michael T. LIU
发明人： Shrikant DESHPANDE , Haichun HUANG , Mohan SRINIVASAN , Josephine M. CARDARELLI , Changyu WANG , David PASSMORE , Vangipuram RANGAN , Thomas E. LANE , Hans S. KEIRSTEAD , Michael T. LIU
IPC分类号： A01K67/027 , C07K16/18 , A61K39/395 , C12N5/18 , C07H21/04 , C12N15/63 , A61P31/12 , A61P31/04
CPC分类号： C07K16/24 , A61K2039/505 , C07K14/522 , C07K2317/21 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要： The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to IP-10 with high affinity, inhibit the binding of IP-10 to its receptor, inhibit IP-10-induced calcium flux and inhibit IP-10-induced cell migration. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting IP-10 activity using the antibodies of the invention, including methods for treating various inflammatory and autoimmune diseases.
摘要翻译： 本发明提供以高亲和力结合IP-10的分离的单克隆抗体，特别是人抗体，抑制IP-10与其受体的结合，抑制IP-10诱导的钙通量并抑制IP-10诱导的细胞迁移 。 还提供了编码本发明抗体的核酸分子，表达载体，宿主细胞和用于表达本发明的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供了使用本发明的抗体来抑制IP-10活性的方法，包括治疗各种炎性和自身免疫性疾病的方法。
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6.发明申请OLIGODENDROCYTES DERIVED FROM HUMAN EMBRYONIC STEM CELLS FOR REMYELINATION AND TREATMENT OF SPINAL CORD INJURY 审中-公开从人类胚胎干细胞衍生的OLIGODENDROCYTES用于再感染和治疗脊髓损伤公开(公告)号：US20090232779A1
公开(公告)日：2009-09-17
申请号：US12357244
申请日：2009-01-21
CPC分类号： C12N5/0622 , A61K35/12 , C12N5/0623 , C12N2501/115 , C12N2501/395 , C12N2503/02 , C12N2506/02
摘要： This invention provides populations of neural cells bearing markers of glial cells, such as oligodendrocytes and their precursors. The populations are generated by differentiating pluripotent stem cells such as human embryonic stem cells under conditions that promote enrichment of cells with the desired phenotype or functional capability. Various combinations of differentiation factors and mitogens can be used to produce cell populations bearing markers of oligodendrocyte precursor cells. Upon further differentiation form complex processes characteristic of mature oligodendrocytes. The cells are capable of forming myelin sheaths, and can be used therapeutically improve function of the central nervous system.
摘要翻译： 本发明提供了具有神经胶质细胞标记物的神经细胞群体，例如少突胶质细胞及其前体。 通过在促进具有所需表型或功能能力的细胞富集的条件下分化多能干细胞例如人胚胎干细胞来产生群体。 分化因子和有丝分裂原的各种组合可用于产生具有少突胶质细胞前体细胞标志物的细胞群。 进一步分化形成成熟的少突胶质细胞特征的复杂过程。 细胞能够形成髓鞘，并且可以用于治疗性地改善中枢神经系统的功能。
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7.发明授权Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury 有权衍生自人类胚胎干细胞的少突胶质细胞用于脊髓损伤的髓鞘再生和治疗公开(公告)号：US07285415B2
公开(公告)日：2007-10-23
申请号：US10406817
申请日：2003-04-04
CPC分类号： C12N5/0622 , A61K35/12 , C12N5/0623 , C12N2501/115 , C12N2501/395 , C12N2503/02 , C12N2506/02
摘要： This invention provides populations of neural cells bearing markers of glial cells, such as oligodendrocytes and their precursors. The populations are generated by differentiating pluripotent stem cells such as human embryonic stem cells under conditions that promote enrichment of cells with the desired phenotype or functional capability. Various combinations of differentiation factors and mitogens can be used to produce cell populations that are over 95% homogeneous in morphological appearance, and the expression of oligodendrocyte markers such as GalC. The cells are capable of forming myelin sheaths, and can be used therapeutically improve function of the central nervous system.
摘要翻译： 本发明提供了具有神经胶质细胞标记物的神经细胞群体，例如少突胶质细胞及其前体。 通过在促进具有所需表型或功能能力的细胞富集的条件下分化多能干细胞例如人胚胎干细胞来产生群体。 分化因子和有丝分裂原的各种组合可用于产生在形态学外观上超过95％同质的细胞群，以及少突胶质细胞标记如GalC的表达。 细胞能够形成髓鞘，并且可以用于治疗性地改善中枢神经系统的功能。
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公开(公告)号：US08258266B2
公开(公告)日：2012-09-04
申请号：US12472877
申请日：2009-05-27
申请人： Shrikant Deshpande , Haichun Huang , Mohan Srinivasan , Josephine M. Cardarelli , Changyu Wang , David B. Passmore , Vangipuram Rangan , Thomas E. Lane , Hans S. Keirstead , Michael T. Liu
发明人： Shrikant Deshpande , Haichun Huang , Mohan Srinivasan , Josephine M. Cardarelli , Changyu Wang , David B. Passmore , Vangipuram Rangan , Thomas E. Lane , Hans S. Keirstead , Michael T. Liu
CPC分类号： C07K16/24 , A61K2039/505 , C07K14/522 , C07K2317/21 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要： The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to IP-10 with high affinity, inhibit the binding of IP-10 to its receptor, inhibit IP-10-induced calcium flux and inhibit IP-10-induced cell migration. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting IP-10 activity using the antibodies of the invention, including methods for treating various inflammatory and autoimmune diseases.
摘要翻译： 本发明提供以高亲和力结合IP-10的分离的单克隆抗体，特别是人抗体，抑制IP-10与其受体的结合，抑制IP-10诱导的钙通量并抑制IP-10诱导的细胞迁移 。 还提供了编码本发明抗体的核酸分子，表达载体，宿主细胞和用于表达本发明的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供了使用本发明的抗体来抑制IP-10活性的方法，包括治疗各种炎性和自身免疫性疾病的方法。
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9.发明授权Immunological composition and its method of use to transiently disrupt mammalian central nervous system myelin to promote neuronal regeneration 失效免疫组成及其使用方法瞬时破坏哺乳动物中枢神经系统髓鞘以促进神经元再生公开(公告)号：US06548061B1
公开(公告)日：2003-04-15
申请号：US09181719
申请日：1998-10-28
IPC分类号： A61K39395
CPC分类号： A61K39/3955 , A61K2300/00
摘要： Novel compositions are described comprising the combined administration of serum complement proteins with complement-fixing antibodies. The antibodies specifically bind to one or more epitopes of myelin, and complement proteins. These compositions are useful for promoting regrowth, repair, and regeneration of neurons in the CNS of a mammalian subject. The compositions and method can be used following immediate or chronic injury.
摘要翻译： 描述新的组合物，其包括将血清补体蛋白与补体定影抗体联合施用。 抗体特异性结合髓鞘和补体蛋白的一个或多个表位。 这些组合物可用于促进哺乳动物受试者的CNS中神经元的再生长，修复和再生。 组合物和方法可以在立即或慢性损伤后使用。
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