公开(公告)号：US20120230998A1

公开(公告)日：2012-09-13

申请号：US13478786

申请日：2012-05-23

申请人： Shrikant DESHPANDE ,  Haichun HUANG ,  Mohan SRINIVASAN ,  Josephine M. CARDARELLI ,  Changyu WANG ,  David PASSMORE ,  Vangipuram RANGAN ,  Thomas E. LANE ,  Hans S. KEIRSTEAD ,  Michael T. LIU

发明人： Shrikant DESHPANDE ,  Haichun HUANG ,  Mohan SRINIVASAN ,  Josephine M. CARDARELLI ,  Changyu WANG ,  David PASSMORE ,  Vangipuram RANGAN ,  Thomas E. LANE ,  Hans S. KEIRSTEAD ,  Michael T. LIU

IPC分类号： A61K39/395 ,  A61P25/00 ,  A61P19/02 ,  A61P29/00 ,  A61P1/00 ,  A61P9/10 ,  A61P17/00 ,  A61P11/00 ,  A61P25/28 ,  A61K48/00 ,  A61P13/12 ,  C12N5/02 ,  A61P3/10

CPC分类号： C07K16/24 ,  A61K2039/505 ,  C07K14/522 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92

摘要： The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to IP-10 with high affinity, inhibit the binding of IP-10 to its receptor, inhibit IP-10-induced calcium flux and inhibit IP-10-induced cell migration. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting IP-10 activity using the antibodies of the invention, including methods for treating various inflammatory and autoimmune diseases.

摘要翻译： 本发明提供以高亲和力结合IP-10的分离的单克隆抗体，特别是人抗体，抑制IP-10与其受体的结合，抑制IP-10诱导的钙通量并抑制IP-10诱导的细胞迁移 。 还提供了编码本发明抗体的核酸分子，表达载体，宿主细胞和用于表达本发明的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供了使用本发明的抗体来抑制IP-10活性的方法，包括治疗各种炎性和自身免疫性疾病的方法。

公开(公告)号：US20100077497A1

公开(公告)日：2010-03-25

申请号：US12472877

申请日：2009-05-27

申请人： Shrikant DESHPANDE ,  Haichun HUANG ,  Mohan SRINIVASAN ,  Josephine M. CARDARELLI ,  Changyu WANG ,  David PASSMORE ,  Vangipuram RANGAN ,  Thomas E. LANE ,  Hans S. KEIRSTEAD ,  Michael T. LIU

发明人： Shrikant DESHPANDE ,  Haichun HUANG ,  Mohan SRINIVASAN ,  Josephine M. CARDARELLI ,  Changyu WANG ,  David PASSMORE ,  Vangipuram RANGAN ,  Thomas E. LANE ,  Hans S. KEIRSTEAD ,  Michael T. LIU

IPC分类号： A01K67/027 ,  C07K16/18 ,  A61K39/395 ,  C12N5/18 ,  C07H21/04 ,  C12N15/63 ,  A61P31/12 ,  A61P31/04

CPC分类号： C07K16/24 ,  A61K2039/505 ,  C07K14/522 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92

摘要： The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to IP-10 with high affinity, inhibit the binding of IP-10 to its receptor, inhibit IP-10-induced calcium flux and inhibit IP-10-induced cell migration. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting IP-10 activity using the antibodies of the invention, including methods for treating various inflammatory and autoimmune diseases.

摘要翻译： 本发明提供以高亲和力结合IP-10的分离的单克隆抗体，特别是人抗体，抑制IP-10与其受体的结合，抑制IP-10诱导的钙通量并抑制IP-10诱导的细胞迁移 。 还提供了编码本发明抗体的核酸分子，表达载体，宿主细胞和用于表达本发明的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供了使用本发明的抗体来抑制IP-10活性的方法，包括治疗各种炎性和自身免疫性疾病的方法。