公开(公告)号：US20120230998A1

公开(公告)日：2012-09-13

申请号：US13478786

申请日：2012-05-23

申请人： Shrikant DESHPANDE ,  Haichun HUANG ,  Mohan SRINIVASAN ,  Josephine M. CARDARELLI ,  Changyu WANG ,  David PASSMORE ,  Vangipuram RANGAN ,  Thomas E. LANE ,  Hans S. KEIRSTEAD ,  Michael T. LIU

发明人： Shrikant DESHPANDE ,  Haichun HUANG ,  Mohan SRINIVASAN ,  Josephine M. CARDARELLI ,  Changyu WANG ,  David PASSMORE ,  Vangipuram RANGAN ,  Thomas E. LANE ,  Hans S. KEIRSTEAD ,  Michael T. LIU

IPC分类号： A61K39/395 ,  A61P25/00 ,  A61P19/02 ,  A61P29/00 ,  A61P1/00 ,  A61P9/10 ,  A61P17/00 ,  A61P11/00 ,  A61P25/28 ,  A61K48/00 ,  A61P13/12 ,  C12N5/02 ,  A61P3/10

CPC分类号： C07K16/24 ,  A61K2039/505 ,  C07K14/522 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92

摘要： The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to IP-10 with high affinity, inhibit the binding of IP-10 to its receptor, inhibit IP-10-induced calcium flux and inhibit IP-10-induced cell migration. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting IP-10 activity using the antibodies of the invention, including methods for treating various inflammatory and autoimmune diseases.

摘要翻译： 本发明提供以高亲和力结合IP-10的分离的单克隆抗体，特别是人抗体，抑制IP-10与其受体的结合，抑制IP-10诱导的钙通量并抑制IP-10诱导的细胞迁移 。 还提供了编码本发明抗体的核酸分子，表达载体，宿主细胞和用于表达本发明的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供了使用本发明的抗体来抑制IP-10活性的方法，包括治疗各种炎性和自身免疫性疾病的方法。

公开(公告)号：US20100077497A1

公开(公告)日：2010-03-25

申请号：US12472877

申请日：2009-05-27

申请人： Shrikant DESHPANDE ,  Haichun HUANG ,  Mohan SRINIVASAN ,  Josephine M. CARDARELLI ,  Changyu WANG ,  David PASSMORE ,  Vangipuram RANGAN ,  Thomas E. LANE ,  Hans S. KEIRSTEAD ,  Michael T. LIU

发明人： Shrikant DESHPANDE ,  Haichun HUANG ,  Mohan SRINIVASAN ,  Josephine M. CARDARELLI ,  Changyu WANG ,  David PASSMORE ,  Vangipuram RANGAN ,  Thomas E. LANE ,  Hans S. KEIRSTEAD ,  Michael T. LIU

IPC分类号： A01K67/027 ,  C07K16/18 ,  A61K39/395 ,  C12N5/18 ,  C07H21/04 ,  C12N15/63 ,  A61P31/12 ,  A61P31/04

CPC分类号： C07K16/24 ,  A61K2039/505 ,  C07K14/522 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92

摘要： The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to IP-10 with high affinity, inhibit the binding of IP-10 to its receptor, inhibit IP-10-induced calcium flux and inhibit IP-10-induced cell migration. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting IP-10 activity using the antibodies of the invention, including methods for treating various inflammatory and autoimmune diseases.

摘要翻译： 本发明提供以高亲和力结合IP-10的分离的单克隆抗体，特别是人抗体，抑制IP-10与其受体的结合，抑制IP-10诱导的钙通量并抑制IP-10诱导的细胞迁移 。 还提供了编码本发明抗体的核酸分子，表达载体，宿主细胞和用于表达本发明的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供了使用本发明的抗体来抑制IP-10活性的方法，包括治疗各种炎性和自身免疫性疾病的方法。

公开(公告)号：US20110028696A1

公开(公告)日：2011-02-03

申请号：US12903853

申请日：2010-10-13

申请人： Josephine M. CARDARELLI ,  David B. PASSMORE ,  Jenny ALBANESE ,  Lei ZHU

发明人： Josephine M. CARDARELLI ,  David B. PASSMORE ,  Jenny ALBANESE ,  Lei ZHU

IPC分类号： C07K16/28 ,  C07K19/00

CPC分类号： C07K16/3069 ,  A61K2039/505 ,  C07K2317/23 ,  C07K2317/41 ,  C07K2317/732 ,  C07K2317/77

摘要： The invention pertains to anti-PSMA antibodies that lack fucosyl residues. The antibodies of the invention exhibit increased antibody-dependent cellular cytotoxicity (ADCC) activity as compared to the fucosylated form of the antibodies. The invention also provides host cells that express the anti-PSMA antibodies that lack fucosyl residues, wherein the host cells are deficient for a fucosyl transferase. Methods of using the antibodies to inhibit the growth of PSMA+ cells, such as tumor cells, are also provided.

摘要翻译： 本发明涉及缺少岩藻糖基残基的抗PSMA抗体。 与抗体的岩藻糖基化形式相比，本发明的抗体表现出增加的抗体依赖性细胞毒性（ADCC）活性。 本发明还提供表达缺乏岩藻糖基残基的抗PSMA抗体的宿主细胞，其中宿主细胞对于岩藻糖基转移酶是缺乏的。 还提供了使用抗体抑制PSMA +细胞如肿瘤细胞生长的方法。

公开(公告)号：US20120251533A1

公开(公告)日：2012-10-04

申请号：US13462566

申请日：2012-05-02

申请人： Josephine M. CARDARELLI ,  Amelia Nancy BLACK

发明人： Josephine M. CARDARELLI ,  Amelia Nancy BLACK

IPC分类号： A61K39/395 ,  A61P7/06 ,  A61P19/02 ,  A61P1/00 ,  A61P13/12 ,  A61P1/04 ,  A61P3/10 ,  A61P31/18 ,  C12N5/07 ,  A61P17/00

CPC分类号： C07K16/2878 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/732

摘要： The invention pertains to anti-CD30 antibodies that lack fucosyl residues. The antibodies of the invention exhibit increased antibody-dependent cellular cytotoxicity (ADCC) activity, including the ability to lyse CD30-expressing cell lines that are not lysed by the fucosylated form of the antibodies. The invention also provides host cells that express the anti-CD30 antibodies that lack fucosyl residues, wherein the host cells are deficient for a fucosyl transferase. Methods of using the antibodies to inhibit the growth of CD30+ cells, such as tumor cells, are also provided.

摘要翻译： 本发明涉及缺乏岩藻糖基残基的抗-CD30抗体。 本发明的抗体表现出增加的抗体依赖性细胞毒性（ADCC）活性，包括裂解不被所述抗体的岩藻糖基化形式裂解的CD30表达细胞系的能力。 本发明还提供表达缺乏岩藻糖基残基的抗-CD30抗体的宿主细胞，其中宿主细胞对于岩藻糖基转移酶是缺陷的。 还提供了使用抗体抑制CD30 +细胞如肿瘤细胞生长的方法。