发明申请
- 专利标题： METHOD FOR PRODUCING MONATIN
- 专利标题（中）： 生产MONATIN的方法
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申请号： US13271280申请日： 2011-10-12
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公开(公告)号： US20120270279A1公开(公告)日： 2012-10-25
- 发明人: Yasuaki Takakura , Hiroomi Ogino , Masakazu Sugiyama , Kenichi Mori , Eri Tabuchi , Koki Ishikawa , Uno Tagami , Hidemi Fujii
- 申请人： Yasuaki Takakura , Hiroomi Ogino , Masakazu Sugiyama , Kenichi Mori , Eri Tabuchi , Koki Ishikawa , Uno Tagami , Hidemi Fujii
- 申请人地址： JP Tokyo
- 专利权人： AJINOMOTO CO. INC
- 当前专利权人： AJINOMOTO CO. INC
- 当前专利权人地址： JP Tokyo
- 主分类号： C12P13/04
- IPC分类号： C12P13/04 ; C12N1/21 ; C07H21/04 ; C12N1/15 ; C12N15/63 ; C12N9/10 ; C12N1/19
摘要：
The present invention provides a methodology for improving a yield of 2R,4R-Monatin. Specifically, the present invention provides a method for producing 2S,4R-Monatin or a salt thereof, comprising contacting 4R-IHOG with an L-amino acid aminotransferase in the presence of an L-amino acid to form the 2S,4R-Monatin; a method for producing 2R,4R-Monatin or a salt thereof, comprising isomerizing the 2S,4R-Monatin to form the 2R,4R-Monatin; and the like. These production methods may further comprise condensing indole-3-pyruvate and pyruvate to form the 4R-IHOG, and deaminating a tryptophan to form the indole-3-pyruvate.