发明申请
- 专利标题： 4-DIMETHYLAMINOBUTYRIC ACID DERIVATIVES
- 专利标题（中）： 4-二甲基氨基丁酸衍生物
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申请号： US13556250申请日： 2012-07-24
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公开(公告)号： US20120289554A1公开(公告)日： 2012-11-15
- 发明人: Mirjana Andjelkovic , Simona M. Ceccarelli , Odile Chomienne , Gerald Lewis Kaplan , Patrizio Mattei , Jefferson Wright Tilley
- 申请人： Mirjana Andjelkovic , Simona M. Ceccarelli , Odile Chomienne , Gerald Lewis Kaplan , Patrizio Mattei , Jefferson Wright Tilley
- 优先权： EP08155323.2 20080429
- 主分类号： A61K31/197
- IPC分类号： A61K31/197 ; C07C235/20 ; C07C233/51 ; C07D333/24 ; C07D277/30 ; C07D213/56 ; C07C317/28 ; C07C317/32 ; C07C231/14 ; C07C275/16 ; A61K31/381 ; A61K31/426 ; A61K31/4406 ; C07C315/04 ; C07C273/18 ; A61P3/10 ; A61P3/04 ; A61P9/12 ; A61P3/00 ; A61P3/06 ; A61P9/10 ; A61P9/04 ; A61P13/12 ; C07C235/12
摘要：
This invention relates to novel 4-dimethylaminobutyric acid derivatives of the formula wherein A1, A2, R1, m and n are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds inhibit carnitine palmitoyl transferase (CPT) activity, in particular CPT2 activity, and can be used as medicaments in methods for the treatment of diseases modulated by CPT2 inhibitors.