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公开(公告)号：US08344027B2
公开(公告)日：2013-01-01
申请号：US12430934
申请日：2009-04-28
申请人： Mirjana Andjelkovic , Simona M. Ceccarelli , Odile Chomienne , Gerald Lewis Kaplan , Patrizio Mattei , Jefferson Wright Tilley
发明人： Mirjana Andjelkovic , Simona M. Ceccarelli , Odile Chomienne , Gerald Lewis Kaplan , Patrizio Mattei , Jefferson Wright Tilley
IPC分类号： A61K31/195 , C07C229/00
CPC分类号： C07D213/56 , C07C237/12 , C07C275/16 , C07C317/44 , C07D277/30 , C07D333/24
摘要： This invention relates to novel 4-dimethylaminobutyric acid derivatives of the formula wherein A1, A2, R1, m and n are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds inhibit carnitine palmitoyl transferase (CPT) activity, in particular CPT2 activity, and can be used as medicaments in methods for the treatment of diseases modulated by CPT2 inhibitors.
摘要翻译： 本发明涉及下式的新型4-二甲基氨基丁酸衍生物，其中A1，A2，R1，m和n如说明书和权利要求中所定义，以及其药学上可接受的盐。 这些化合物抑制肉碱棕榈酰转移酶（CPT）活性，特别是CPT2活性，可用作治疗由CPT2抑制剂调节的疾病的方法中的药物。
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公开(公告)号：US20120289554A1
公开(公告)日：2012-11-15
申请号：US13556250
申请日：2012-07-24
申请人： Mirjana Andjelkovic , Simona M. Ceccarelli , Odile Chomienne , Gerald Lewis Kaplan , Patrizio Mattei , Jefferson Wright Tilley
发明人： Mirjana Andjelkovic , Simona M. Ceccarelli , Odile Chomienne , Gerald Lewis Kaplan , Patrizio Mattei , Jefferson Wright Tilley
IPC分类号： A61K31/197 , C07C235/20 , C07C233/51 , C07D333/24 , C07D277/30 , C07D213/56 , C07C317/28 , C07C317/32 , C07C231/14 , C07C275/16 , A61K31/381 , A61K31/426 , A61K31/4406 , C07C315/04 , C07C273/18 , A61P3/10 , A61P3/04 , A61P9/12 , A61P3/00 , A61P3/06 , A61P9/10 , A61P9/04 , A61P13/12 , C07C235/12
CPC分类号： C07D213/56 , C07C237/12 , C07C275/16 , C07C317/44 , C07D277/30 , C07D333/24
摘要： This invention relates to novel 4-dimethylaminobutyric acid derivatives of the formula wherein A1, A2, R1, m and n are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds inhibit carnitine palmitoyl transferase (CPT) activity, in particular CPT2 activity, and can be used as medicaments in methods for the treatment of diseases modulated by CPT2 inhibitors.
摘要翻译： 本发明涉及下式的新型4-二甲基氨基丁酸衍生物，其中A1，A2，R1，m和n如说明书和权利要求中所定义，以及其药学上可接受的盐。 这些化合物抑制肉碱棕榈酰转移酶（CPT）活性，特别是CPT2活性，可用作治疗由CPT2抑制剂调节的疾病的方法中的药物。
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公开(公告)号：US20090270505A1
公开(公告)日：2009-10-29
申请号：US12430934
申请日：2009-04-28
申请人： Mirjana Andjelkovic , Simona M. Ceccarelli , Odile Chomienne , Gerald Lewis Kaplan , Patrizio Mattei , Jefferson Wright Tilley
发明人： Mirjana Andjelkovic , Simona M. Ceccarelli , Odile Chomienne , Gerald Lewis Kaplan , Patrizio Mattei , Jefferson Wright Tilley
IPC分类号： A61K31/195 , C07C229/00
CPC分类号： C07D213/56 , C07C237/12 , C07C275/16 , C07C317/44 , C07D277/30 , C07D333/24
摘要： This invention relates to novel 4-dimethylaminobutyric acid derivatives of the formula wherein A1, A2, R1, m and n are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds inhibit carnitine palmitoyl transferase (CPT) activity, in particular CPT2 activity, and can be used as medicaments in methods for the treatment of diseases modulated by CPT2 inhibitors.
摘要翻译： 本发明涉及下式的新型4-二甲基氨基丁酸衍生物，其中A1，A2，R1，m和n如说明书和权利要求中所定义，以及其药学上可接受的盐。 这些化合物抑制肉碱棕榈酰转移酶（CPT）活性，特别是CPT2活性，可用作治疗由CPT2抑制剂调节的疾病的方法中的药物。
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公开(公告)号：US06916933B2
公开(公告)日：2005-07-12
申请号：US10670182
申请日：2003-09-24
IPC分类号： C07D213/64 , C07D213/70 , C07D211/72 , C07D401/00 , C07D405/00 , C07D417/00
CPC分类号： C07D213/64
摘要： Compounds of Formula I have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4 and are useful for treating disease whose symptoms and or damage are related to the binding of VCAM-1 to cells expressing VLA-4.
摘要翻译： 式I的化合物具有作为VCAM-1与表达VLA-4的细胞之间结合的抑制剂的活性，并且可用于治疗其症状和/或损伤与VCAM-1与表达VLA-4的细胞结合相关的疾病。
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公开(公告)号：US06388084B1
公开(公告)日：2002-05-14
申请号：US09717684
申请日：2000-11-21
IPC分类号： C07D21172
CPC分类号： C07D213/64
摘要： Compounds of Formula I have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4 and are useful for treating disease whose symptoms and or damage are related to the binding of VCAM-1 to cells expressing VLA-4.
摘要翻译： 式I的化合物具有作为VCAM-1与表达VLA-4的细胞之间结合的抑制剂的活性，并且可用于治疗其症状和/或损伤与VCAM-1与表达VLA-4的细胞结合相关的疾病。
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