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公开(公告)号:US08344027B2
公开(公告)日:2013-01-01
申请号:US12430934
申请日:2009-04-28
申请人: Mirjana Andjelkovic , Simona M. Ceccarelli , Odile Chomienne , Gerald Lewis Kaplan , Patrizio Mattei , Jefferson Wright Tilley
发明人: Mirjana Andjelkovic , Simona M. Ceccarelli , Odile Chomienne , Gerald Lewis Kaplan , Patrizio Mattei , Jefferson Wright Tilley
IPC分类号: A61K31/195 , C07C229/00
CPC分类号: C07D213/56 , C07C237/12 , C07C275/16 , C07C317/44 , C07D277/30 , C07D333/24
摘要: This invention relates to novel 4-dimethylaminobutyric acid derivatives of the formula wherein A1, A2, R1, m and n are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds inhibit carnitine palmitoyl transferase (CPT) activity, in particular CPT2 activity, and can be used as medicaments in methods for the treatment of diseases modulated by CPT2 inhibitors.
摘要翻译: 本发明涉及下式的新型4-二甲基氨基丁酸衍生物,其中A1,A2,R1,m和n如说明书和权利要求中所定义,以及其药学上可接受的盐。 这些化合物抑制肉碱棕榈酰转移酶(CPT)活性,特别是CPT2活性,可用作治疗由CPT2抑制剂调节的疾病的方法中的药物。
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公开(公告)号:US20120289554A1
公开(公告)日:2012-11-15
申请号:US13556250
申请日:2012-07-24
申请人: Mirjana Andjelkovic , Simona M. Ceccarelli , Odile Chomienne , Gerald Lewis Kaplan , Patrizio Mattei , Jefferson Wright Tilley
发明人: Mirjana Andjelkovic , Simona M. Ceccarelli , Odile Chomienne , Gerald Lewis Kaplan , Patrizio Mattei , Jefferson Wright Tilley
IPC分类号: A61K31/197 , C07C235/20 , C07C233/51 , C07D333/24 , C07D277/30 , C07D213/56 , C07C317/28 , C07C317/32 , C07C231/14 , C07C275/16 , A61K31/381 , A61K31/426 , A61K31/4406 , C07C315/04 , C07C273/18 , A61P3/10 , A61P3/04 , A61P9/12 , A61P3/00 , A61P3/06 , A61P9/10 , A61P9/04 , A61P13/12 , C07C235/12
CPC分类号: C07D213/56 , C07C237/12 , C07C275/16 , C07C317/44 , C07D277/30 , C07D333/24
摘要: This invention relates to novel 4-dimethylaminobutyric acid derivatives of the formula wherein A1, A2, R1, m and n are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds inhibit carnitine palmitoyl transferase (CPT) activity, in particular CPT2 activity, and can be used as medicaments in methods for the treatment of diseases modulated by CPT2 inhibitors.
摘要翻译: 本发明涉及下式的新型4-二甲基氨基丁酸衍生物,其中A1,A2,R1,m和n如说明书和权利要求中所定义,以及其药学上可接受的盐。 这些化合物抑制肉碱棕榈酰转移酶(CPT)活性,特别是CPT2活性,可用作治疗由CPT2抑制剂调节的疾病的方法中的药物。
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公开(公告)号:US20090270505A1
公开(公告)日:2009-10-29
申请号:US12430934
申请日:2009-04-28
申请人: Mirjana Andjelkovic , Simona M. Ceccarelli , Odile Chomienne , Gerald Lewis Kaplan , Patrizio Mattei , Jefferson Wright Tilley
发明人: Mirjana Andjelkovic , Simona M. Ceccarelli , Odile Chomienne , Gerald Lewis Kaplan , Patrizio Mattei , Jefferson Wright Tilley
IPC分类号: A61K31/195 , C07C229/00
CPC分类号: C07D213/56 , C07C237/12 , C07C275/16 , C07C317/44 , C07D277/30 , C07D333/24
摘要: This invention relates to novel 4-dimethylaminobutyric acid derivatives of the formula wherein A1, A2, R1, m and n are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds inhibit carnitine palmitoyl transferase (CPT) activity, in particular CPT2 activity, and can be used as medicaments in methods for the treatment of diseases modulated by CPT2 inhibitors.
摘要翻译: 本发明涉及下式的新型4-二甲基氨基丁酸衍生物,其中A1,A2,R1,m和n如说明书和权利要求中所定义,以及其药学上可接受的盐。 这些化合物抑制肉碱棕榈酰转移酶(CPT)活性,特别是CPT2活性,可用作治疗由CPT2抑制剂调节的疾病的方法中的药物。
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公开(公告)号:US08039487B2
公开(公告)日:2011-10-18
申请号:US12125976
申请日:2008-05-23
IPC分类号: C07D401/04 , C07D401/14 , A61K31/4535 , A61K31/4545 , A61P3/00 , A61P9/00
CPC分类号: C07D417/04 , C07D417/14
摘要: The invention is concerned with novel piperidine-amide derivatives of formula (I) wherein R1, R2, X and Y are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit L-CPT1 and may be used to treat diseases associated with L-CPT1.
摘要翻译: 本发明涉及式(I)的新的哌啶 - 酰胺衍生物,其中R 1,R 2,X和Y如说明书和权利要求书中所定义,以及其生理上可接受的盐和酯。 这些化合物抑制L-CPT1,可用于治疗与L-CPT1相关的疾病。
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公开(公告)号:US20090270500A1
公开(公告)日:2009-10-29
申请号:US12430941
申请日:2009-04-28
IPC分类号: A61K31/205 , C07C229/04 , A61P3/10
CPC分类号: A61K31/205 , A61K31/381 , C07C231/12 , C07C233/51 , C07C235/12 , C07D333/20 , C07D333/24
摘要: This invention relates to novel 4-trimethylammoniobutyrates of the formula wherein A1, R1, m and n are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds inhibit carnitine palmitoyl transferase (CPT) activity, in particular CPT2 activity, and can be used as medicaments.
摘要翻译: 本发明涉及下式的新型4-三甲基铵丁酸酯,其中A1,R1,m和n如说明书和权利要求书中所定义,以及其药学上可接受的盐。 这些化合物抑制肉碱棕榈酰转移酶(CPT)活性,特别是CPT2活性,可用作药物。
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公开(公告)号:US20080300279A1
公开(公告)日:2008-12-04
申请号:US12125976
申请日:2008-05-23
IPC分类号: A61K31/4535 , C07D401/04
CPC分类号: C07D417/04 , C07D417/14
摘要: The invention is concerned with novel piperidine-amide derivatives of formula (I) wherein R1, R2, X and Y are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit L-CPT1 and may be used to treat diseases associated with L-CPT1.
摘要翻译: 本发明涉及式(I)的新的哌啶 - 酰胺衍生物,其中R 1,R 2,X和Y如说明书和权利要求书中所定义,以及其生理上可接受的盐和酯。 这些化合物抑制L-CPT1,可用于治疗与L-CPT1相关的疾病。
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公开(公告)号:US08349893B2
公开(公告)日:2013-01-08
申请号:US12430941
申请日:2009-04-28
IPC分类号: A61K31/205 , C07C229/04 , A61P3/10
CPC分类号: A61K31/205 , A61K31/381 , C07C231/12 , C07C233/51 , C07C235/12 , C07D333/20 , C07D333/24
摘要: This invention relates to novel 4-trimethylammoniobutyrates of the formula wherein A1, R1, m and n are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds inhibit carnitine palmitoyl transferase (CPT) activity, in particular CPT2 activity, and can be used as medicaments.
摘要翻译: 本发明涉及下式的新型4-三甲基铵丁酸酯,其中A1,R1,m和n如说明书和权利要求书中所定义,以及其药学上可接受的盐。 这些化合物抑制肉碱棕榈酰转移酶(CPT)活性,特别是CPT2活性,可用作药物。
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公开(公告)号:US08071628B2
公开(公告)日:2011-12-06
申请号:US12877160
申请日:2010-09-08
IPC分类号: A61K31/4439 , A61K31/416 , A61K31/427 , A61K31/4245 , C07D231/56 , C07D409/12 , C07D405/12 , C07D413/12
CPC分类号: C07D231/56 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要: The invention is concerned with novel indazole derivatives of formula (I) wherein R1, R2, R3, R4, R5, R6, X and Y are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit L-CPT1 and can be used in the prevention or treatment of diseases which are modulated by L-CPT1 inhibitors.
摘要翻译: 本发明涉及式(I)的新的吲唑衍生物,其中R 1,R 2,R 3,R 4,R 5,R 6,X和Y如说明书和权利要求书中所定义,以及其生理上可接受的盐和酯。 这些化合物抑制L-CPT1,可用于预防或治疗由L-CPT1抑制剂调节的疾病。
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公开(公告)号:US20080103182A1
公开(公告)日:2008-05-01
申请号:US11875025
申请日:2007-10-19
IPC分类号: A61K31/416 , A61K31/4155 , A61K31/4245 , A61K31/4439 , C07D231/56 , C07D401/02 , C07D403/02 , C07D413/02
CPC分类号: C07D231/56 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要: The invention is concerned with novel indazole derivatives of formula (I) wherein R1, R2, R3, R4, R5, R6, X and Y are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit L-CPT1 and can be used in the prevention or treatment of diseases which are modulated by L-CPT1 inhibitors.
摘要翻译: 本发明涉及式(I)的新的吲唑衍生物,其中R 1,R 2,R 3,R 4, R 5,R 6,X 6,X和Y如说明书和权利要求书中所定义,以及其生理上可接受的盐和酯。 这些化合物抑制L-CPT1,可用于预防或治疗由L-CPT1抑制剂调节的疾病。
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10.
公开(公告)号:US08030308B2
公开(公告)日:2011-10-04
申请号:US12941374
申请日:2010-11-08
申请人: Jean Ackermann , Konrad Bleicher , Simona M. Ceccarelli , Odile Chomienne , Patrizio Mattei , Ulrike Obst Sander
发明人: Jean Ackermann , Konrad Bleicher , Simona M. Ceccarelli , Odile Chomienne , Patrizio Mattei , Ulrike Obst Sander
IPC分类号: C07D241/50 , C07D265/36 , C07D413/12 , A61K31/553
CPC分类号: C07D265/36 , C07D241/42 , C07D263/56 , C07D265/14 , C07D267/14 , C07D279/16 , C07D413/12 , C07D417/12 , C07D491/04
摘要: The invention is concerned with novel heterobicyclic derivatives of formula (I) wherein R1, R2, R3, R4, R5, R6, V, W, X and Y are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit L-CPT1 and can be used as medicaments.
摘要翻译: 本发明涉及式(I)的新型杂双环衍生物,其中R 1,R 2,R 3,R 4,R 5,R 6,V,W,X和Y如说明书和权利要求书中所定义,以及生理上可接受的盐 及其酯。 这些化合物抑制L-CPT1,可用作药物。
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