发明申请
- 专利标题： MOLECULES RELATED hERG ION CHANNELS AND THE USE THEREOF
- 专利标题（中）： 分子相关通道及其用途
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申请号： US13519424申请日： 2010-12-16
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公开(公告)号： US20120329865A1公开(公告)日： 2012-12-27
- 发明人: Huayun Deng , Ye Fang , Ann MeeJin Ferrie , Mingqian He , Weijun Niu , Haiyan Sun , Elizabeth Tran , Ying Wei
- 申请人： Huayun Deng , Ye Fang , Ann MeeJin Ferrie , Mingqian He , Weijun Niu , Haiyan Sun , Elizabeth Tran , Ying Wei
- 国际申请： PCT/US2010/060655 WO 20101216
- 主分类号： A61K31/341
- IPC分类号： A61K31/341 ; C12N5/071 ; A61P35/00 ; G01N21/17 ; A61K31/343 ; A61P35/02
摘要：
Disclosed are compounds having structural formula (I, II) or a pharmaceutically acceptable sale, solvate, clathrate, or prodrug thereof, wherein R1, R2, R3, R6, R5, and R4 are defined herein. These compounds can be useful as therapeutic agents for modulating hERG ion channels, and for improving prevention and treatment of hERG associated cardiac repolarization disorders.
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