Abstract:
A method and apparatus, as defined herein, for use in compound screening, compound profiling, or both assays, for example, against two different cellular targets in, for example, a single cell-type.
Abstract:
An optical sensor for label-independent detection, having improved spatial resolution and reduced angular sensitivity, the sensor including: a substrate; a waveguide grating adjacent the substrate; and a waveguide coat layer adjacent or over the waveguide grating, the waveguide coat layer having a thickness (W) of from 30 nm to 300 nm, the waveguide grating having a teeth height (H) of from 0.2×W to 1×W, and for example, a waveguide core thickness (Wcore=W−H) from 5 nm to 50 nm. Also disclosed is a well-plate article, a well-plate reader system, and methods of using the well-plate and sensor articles, as defined herein.
Abstract:
Disclosed are methods to characterize PI3K inhibitors and Rho kinase inhibitors using label-free cellular assays. Disclosed are also methods to characterize a cell whether it has a deregulated PI3K pathway or not.
Abstract:
A cervical brace for restraining movement of a head and neck vertebra of a patient relative to at least one of a chest and an abdomen of the patient. The brace includes a mount sized and shaped for attachment to at least one of the chest and the abdomen of the patient and a support extending upward from the mount to a position in use adjacent a rearward surface of the head of the patient. The brace includes a loop sized and shaped for receiving the head of the patient cantilevered from the support. The support includes at least one joint for adjusting at least one of a pitch, a yaw and a roll of the loop relative to the mount.
Abstract:
The disclosure provides methods for characterizing the toxicity of a candidate molecule to liver cells as defined herein; methods of culturing metabolically active liver cells on a biosensor as defined herein; and biosensor liver culture systems as defined herein.
Abstract:
Disclosed are compounds having structural formula (I, II) or a pharmaceutically acceptable sale, solvate, clathrate, or prodrug thereof, wherein R1, R2, R3, R6, R5, and R4 are defined herein. These compounds can be useful as therapeutic agents for modulating hERG ion channels, and for improving prevention and treatment of hERG associated cardiac repolarization disorders.
Abstract:
Disclosed is an apparatus for measuring ligand-induced cell activity as defined herein, the apparatus including: an optical biosensor having a contact surface including a compatibilizer zone, an optional surface modifier zone, and a live cell zone. The disclosure also provides a method of making the apparatus and methods for measuring ligand-induced live cell activity with the apparatus.
Abstract:
196. Disclosed are methods of incubating cells on biosensors, and methods using the disclosed incubation techniques to identify PDE4 modulators.
Abstract:
A method and apparatus, as defined herein, for use in compound screening, compound profiling, or both assays, for example, against two different cellular targets in, for example, a single cell-type.