发明申请
- 专利标题： GLUCOSE DEPENDENT INSULINOTROPIC POLYPEPTIDE ANALOGS, PHARMACEUTICAL COMPOSITIONS AND USE THEREOF
- 专利标题（中）： 葡萄糖依赖性胰岛素多肽类似物，药物组合物及其用途
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申请号： US14125061申请日： 2012-06-08
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公开(公告)号： US20140162945A1公开(公告)日： 2014-06-12
- 发明人: Tao Ma , Shusen Xu , Zhijun Liu , Bo Zhang , Ning Shen , Hai Yang , Wei Zhang , Yuhua Li , Sunghwan Moon , Maengsup Kim
- 申请人： Tao Ma , Shusen Xu , Zhijun Liu , Bo Zhang , Ning Shen , Hai Yang , Wei Zhang , Yuhua Li , Sunghwan Moon , Maengsup Kim
- 申请人地址： CN Beijing
- 专利权人： BEIJING HANMI PHARMACEUTICAL CO., LTD.
- 当前专利权人： BEIJING HANMI PHARMACEUTICAL CO., LTD.
- 当前专利权人地址： CN Beijing
- 优先权： CN201110156296.2 20110610
- 国际申请： PCT/CN2012/076677 WO 20120608
- 主分类号： C07K14/575
- IPC分类号： C07K14/575
摘要：
The present invention provides a GIP analog, which is derived from GIP (1-29, SEQ ID NO: 1), has both GLP-1 agonist activity and GIPR stimulation activity, and comprises an amino acid sequence represented by the following formula I: Tyr-A2-A3-Gly-Thr-Phe-A7-Ser-Asp-Tyr-Ser-A12-A13-A14-A15-Lys-A17-A18-A19-A20-A21-A22-A23-A24-Trp-Leu-A27-A28-A29-Y. The present invention also provides a pharmaceutical composition comprising the GIP analog and use thereof.
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