摘要:
The present invention provides a GIP analog, which is derived from GIP (1-29, SEQ ID NO: 1), has both GLP-1 agonist activity and GIPR stimulation activity, and comprises an amino acid sequence represented by the following formula I: Tyr-A2-A3-Gly-Thr-Phe-A7-Ser-Asp-Tyr-Ser-A12-A13-A14-A15-Lys-A17-A18-A19-A20-A21-A22-A23-A24-Trp-Leu- A27-A28-A29-Y. The present invention also provides a pharmaceutical composition comprising the GIP analog and use thereof.
摘要翻译:本发明提供衍生自GIP(1-29,SEQ ID NO:1)的GIP类似物具有GLP-1激动剂活性和GIPR刺激活性,并且包含由下式I表示的氨基酸序列: Tyr-A2-A3-Gly-Thr-Phe-A7-Ser-Asp-Tyr-Ser-A12-A13-A14-A15-Lys-A17-A18-A19-A20-A21-A22-A23-A24-Trp- Leu- A27-A28-A29-Y。 本发明还提供了包含GIP类似物及其用途的药物组合物。
摘要:
The present invention provides a GIP analog, which is derived from GIP (1-29, SEQ ID NO: 1), has both GLP-1 agonist activity and GIPR stimulation activity, and comprises an amino acid sequence represented by the following formula I: Tyr-A2-A3-Gly-Thr-Phe-A7-Ser-Asp-Tyr-Ser-A12-A13-A14-A15-Lys-A17-A18-A19-A20-A21-A22-A23-A24-Trp-Leu-A27-A28-A29-Y. The present invention also provides a pharmaceutical composition comprising the GIP analog and use thereof.
摘要翻译:本发明提供衍生自GIP(1-29,SEQ ID NO:1)的GIP类似物具有GLP-1激动剂活性和GIPR刺激活性,并且包含由下式I表示的氨基酸序列: Tyr-A2-A3-Gly-Thr-Phe-A7-Ser-Asp-Tyr-Ser-A12-A13-A14-A15-Lys-A17-A18-A19-A20-A21-A22-A23-A24-Trp- Leu-A27-A28-A29-Y。 本发明还提供了包含GIP类似物及其用途的药物组合物。
摘要:
A liquid crystal display, comprising an array substrate and a color filter substrate, wherein a combination type mark is disposed on both of the array substrate and the color filter substrate, and the combination type mark comprises a rough mark and a fine mark that is located around the rough mark; and wherein the rough mark on the array substrate corresponds to the rough mark on the color filter substrate, and the fine mark on the array substrate corresponds to the fine mark on the color filter substrate.
摘要:
The present invention provides for a stabilized biodegradable polymeric composition useful as a controlled release delivery system for peptide agents. The compositions of the present invention comprise a) a beneficial salt of a luteinizing hormone releasing hormone (LHRH) analogue formed with a strong acid that minimizes or prevents the interaction/reaction between the LHRH and the polymer in an organic solution; b) a biodegradable polymer; c) a pharmaceutically acceptable organic solvent; and d) optionally one or more excipients. The present invention also relates to a method of manufacturing and a method of use thereof.
摘要:
The present invention provides a novel liquid composition suitable for in-situ formation of a depot system to deliver a bioactive substance in a controlled manner. The composition of the present invention comprises: (a) a hydrophobic non-polymeric carrier material; (b) a water miscible biocompatible organic solvent that dissolves the hydrophobic non-polymeric material; (c) an ionic complex that is formed between an amphiphilic molecule and a bioactive substance having a net charge at neutral pH in water. The present invention also provides a method of manufacturing and use of the composition thereof.
摘要:
The present embodiments are directed to compositions and methods of delivering the compositions that comprise mitomycin C and superior magnetically targetable carrier particles. As the compositions are magnetically targetable, their use allows the localization of mitomycin C to particular locations within a patient. This allows for an increase in the effective concentration or a decrease in systemic exposure of mitomycin C in a patient.
摘要:
A method employs a database table that contains progressive prize pool status data for each progressive game that may be available in a given gaming system. Additional database tables store definitions for both contributions to the various progressive prize pools and awards to be made from the various progressive prize pools. A given game play request in the gaming system is identified with a particular contribution definition from the applicable database table in order to properly update the applicable progressive prize pool in view of the game play request and the wager associated with that game play request. Also, a given result in a game offered through the gaming system is identified with a particular award definition in order to identify when a progressive prize is to be awarded and to properly award the applicable progressive prize and update the progressive prize pool.
摘要:
The present invention relates to a conductive particle, a conductive adhesive with the conductive particles, a LCD panel with the conductive adhesive, a method of manufacturing of the conductive particle and a method of manufacturing of the conductive adhesive. The conductive particle comprising an outer coating layer of graphite and an inner core of an organic resin enclosed by the outer coating layer, and therefore the conductive particles can have good conductivity as well as good strength and elasticity.
摘要:
The present invention provides methods of forming a solid, biodegradable implant in-situ in a body by administering a liquid pharmaceutical composition comprising an effective amount of a biocompatible, water-insoluble, biodegradable polymer and an effective amount of a therapeutic peptide covalently modified with one or more lipophilic or amphiphilic moieties, which are dissolved or dispersed in a biocompatible, water-soluble organic solvent. This invention also provides related compositions and methods.
摘要:
The present invention provides a novel liquid composition suitable for in-situ formation of a depot system to deliver a bioactive substance in a controlled manner. The composition of the present invention comprises: (a) a hydrophobic non-polymeric carrier material; (b) a water miscible biocompatible organic solvent that dissolves the hydrophobic non-polymeric material; (c) an ionic complex that is formed between an amphiphilic molecule and a bioactive substance having a net charge at neutral pH in water. The present invention also provides a method of manufacturing and use of the composition thereof.