发明申请
- 专利标题： DUAL-ACTING OXAZOLE ANTIHYPERTENSIVE AGENTS
- 专利标题（中）： 双作用奥沙唑抗菌剂
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申请号： US14062004申请日： 2013-10-24
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公开(公告)号： US20140194426A1公开(公告)日： 2014-07-10
- 发明人: Paul R. Fatheree , Ryan Hudson , Robert Murray McKinnell
- 申请人： Paul R. Fatheree , Ryan Hudson , Robert Murray McKinnell
- 申请人地址： US CA South San Francisco
- 专利权人： THERAVANCE, INC.
- 当前专利权人： THERAVANCE, INC.
- 当前专利权人地址： US CA South San Francisco
- 主分类号： C07D413/14
- IPC分类号： C07D413/14 ; C07D263/34 ; C07D413/12 ; C07D413/10
摘要：
In one aspect, the invention relates to compounds having the formula: wherein: Ar, Z, R3, R4 and R5 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
公开/授权文献
- US09181206B2 Dual-acting oxazole antihypertensive agents 公开/授权日：2015-11-10
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