发明申请
US20150119576A1 METHOD FOR PRODUCTION OF 3-HYDROXYPROPAN-1-ONE COMPOUND, METHOD FOR PRODUCTION OF 2-PROPEN-1-ONE COMPOUND AND METHOD FOR PRODUCTION OF ISOXAZOLINE COMPOUND
审中-公开
3-羟基丙-1-酮化合物的生产方法,2-丙烯-1-酮化合物的生产方法和用于生产异辛唑化合物的方法
- 专利标题: METHOD FOR PRODUCTION OF 3-HYDROXYPROPAN-1-ONE COMPOUND, METHOD FOR PRODUCTION OF 2-PROPEN-1-ONE COMPOUND AND METHOD FOR PRODUCTION OF ISOXAZOLINE COMPOUND
- 专利标题(中): 3-羟基丙-1-酮化合物的生产方法,2-丙烯-1-酮化合物的生产方法和用于生产异辛唑化合物的方法
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申请号: US14584642申请日: 2014-12-29
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公开(公告)号: US20150119576A1公开(公告)日: 2015-04-30
- 发明人: Manabu YAOSAKA , Tomohisa UTSUNOMIYA , Yuji MORIYAMA , Tomohiro MATSUMOTO , Kazutaka MATOBA
- 申请人: NISSAN CHEMICAL INDUSTRIES, LTD.
- 主分类号: C07C45/72
- IPC分类号: C07C45/72 ; C07C231/12 ; C07D213/04 ; C07D413/14 ; C07D249/08 ; C07D233/60 ; C07D401/04 ; C07D413/12 ; C07C51/353 ; C07C67/343
摘要:
There is provided a novel intermediate for producing pesticides. A method for producing the compound of Formula (3) comprises reacting an aromatic ketone compound of Formula (4) and a substituted acetophenone compound of Formula (5) as starting raw materials in an organic solvent or water in the presence or absence of an additive in the presence of a base in a suspended state. A method may comprise dehydrating the compound of Formula (3). A method for producing compound (2) in one step comprises reacting compound (4) and compound (5) to obtain compound (3). Further, a method for producing an isoxazoline compound of Formula (1) comprises reacting compound (2) and a hydroxylamine in an aliphatic or an aromatic hydrocarbon solvent which is optionally substituted by a halogen atom by adding an additive selected from a phase-transfer catalyst, a C1-C6 alcohol and an aprotic polar solvent in the presence of a base and water.
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