公开(公告)号：US20150119576A1

公开(公告)日：2015-04-30

申请号：US14584642

申请日：2014-12-29

申请人： NISSAN CHEMICAL INDUSTRIES, LTD.

发明人： Manabu YAOSAKA ,  Tomohisa UTSUNOMIYA ,  Yuji MORIYAMA ,  Tomohiro MATSUMOTO ,  Kazutaka MATOBA

IPC分类号： C07C45/72 ,  C07C231/12 ,  C07D213/04 ,  C07D413/14 ,  C07D249/08 ,  C07D233/60 ,  C07D401/04 ,  C07D413/12 ,  C07C51/353 ,  C07C67/343

CPC分类号： C07C45/72 ,  C07C45/66 ,  C07C45/74 ,  C07C49/83 ,  C07C49/835 ,  C07C51/353 ,  C07C51/367 ,  C07C51/377 ,  C07C65/40 ,  C07C67/327 ,  C07C67/343 ,  C07C67/347 ,  C07C69/65 ,  C07C231/12 ,  C07C253/30 ,  C07C319/20 ,  C07D213/30 ,  C07D213/50 ,  C07D213/61 ,  C07D233/14 ,  C07D249/08 ,  C07D261/04 ,  C07D401/04 ,  C07C323/22 ,  C07C235/84 ,  C07C255/56 ,  C07C69/76 ,  C07C49/813 ,  C07C65/38

摘要： There is provided a novel intermediate for producing pesticides. A method for producing the compound of Formula (3) comprises reacting an aromatic ketone compound of Formula (4) and a substituted acetophenone compound of Formula (5) as starting raw materials in an organic solvent or water in the presence or absence of an additive in the presence of a base in a suspended state. A method may comprise dehydrating the compound of Formula (3). A method for producing compound (2) in one step comprises reacting compound (4) and compound (5) to obtain compound (3). Further, a method for producing an isoxazoline compound of Formula (1) comprises reacting compound (2) and a hydroxylamine in an aliphatic or an aromatic hydrocarbon solvent which is optionally substituted by a halogen atom by adding an additive selected from a phase-transfer catalyst, a C1-C6 alcohol and an aprotic polar solvent in the presence of a base and water.

摘要翻译： 提供了一种生产农药的新型中间体。 制备式（3）化合物的方法包括使式（4）的芳族酮化合物和式（5）的取代的苯乙酮化合物作为起始原料，在存在或不存在添加剂的情况下，在有机溶剂或水中反应 在有悬浮状态的基地的情况下。 一种方法可以包括使式（3）的化合物脱水。 一步法制备化合物（2）的方法包括使化合物（4）和化合物（5）反应得到化合物（3）。 此外，制备式（1）的异恶唑啉化合物的方法包括使任选被卤素原子取代的脂族或芳族烃溶剂中的化合物（2）与羟胺反应，加入选自相转移催化剂 ，C1-C6醇和非质子极性溶剂在碱和水的存在下反应。

公开(公告)号：US20170065565A1

公开(公告)日：2017-03-09

申请号：US15097002

申请日：2016-04-12

申请人： NISSAN CHEMICAL INDUSTRIES, LTD.

发明人： Takeshi Mita ,  Takamasa KIKUCHI ,  Takashi MIZUKOSHI ,  Manabu YAOSAKA ,  Mitsuaki KOMODA

IPC分类号： A61K31/421 ,  A61K9/00

CPC分类号： A61K31/421 ,  A01N43/80 ,  A61K9/0053 ,  C07C25/02 ,  C07C25/06 ,  C07C25/08 ,  C07C25/13 ,  C07C25/24 ,  C07C43/1742 ,  C07C43/1745 ,  C07C205/11 ,  C07C205/12 ,  C07C211/52 ,  C07C251/48 ,  C07C255/29 ,  C07C255/50 ,  C07C255/60 ,  C07C281/02 ,  C07C323/09 ,  C07D261/04 ,  C07D261/16 ,  C07D413/04 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/06 ,  C07D417/12 ,  C07F7/0812

摘要： A substituted alkenylbenzene compound of formula (4): wherein X1 is selected from the group consisting of halogen atom, —SF5, C1-C6halo alkyl, hydroxy C1-C6haloalkyl, C1-C6alkoxy C1-C6haloalkyl, C3-C8halocycloalkyl, C1-C6 haloalkoxy, C1-C3haloalkoxy C1-C3haloalkoxy, C1-C6haloalkylthio, C1-C6haloalkylsulfinyl and C1-C6haloalkylsulfonyl; X3 is selected from the group consisting of a hydrogen atom, halogen atom, cyano, nitro, C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy and C1-C6 alkylthio; X4 is selected from the group consisting of a hydrogen atom, halogen atom, cyano, C1-C4alkyl, C1-C4alkoxy and C1-C4haloalkoxy; R3 is —C(R3a)(R3b)R3c, where R3a and R3b independently of each other are a halogen atom, or R3a and R3b together form 3- to 6-membered ring together with the carbon atom bonding them by forming a C2-C5haloalkylene chain, and R3c is selected from the group consisting of a hydrogen atom, halogen atom, C1-C5alkyl, C1-C5haloalkyl, C1-C4haloalkoxy and C1-C4haloalkylthio, with a proviso that in case where X1 is a fluorine atom, chlorine atom or trifluoromethyl, and both X2 and X3 are a hydrogen atom, in case where both X1 and X2 are fluorine atom and X3 is a hydrogen atom, and in case where both X1 and X2 are trifluoromethyl and X3 is a hydrogen atom, R3c is a hydrogen atom, chlorine atom, bromine atom, iodine atom, C1-C5alkyl, C1-C5haloalkyl, C1-C4haloalkoxy or C1-C4haloalkylthio.

摘要翻译： 其中X 1选自卤素原子，-SF 5，C 1 -C 6卤代烷基，羟基C 1 -C 6卤代烷基，C 1 -C 6烷氧基C 1 -C 6卤代烷基，C 3 -C 8卤代环烷基，C 1 -C 6卤代烷氧基，C 1 -C 3卤代烷氧基，C 1 -C 3卤代烷氧基， C 6卤代烷硫基，C 1 -C 6卤代烷基亚磺酰基和C 1 -C 6卤代烷基磺酰基; X 3选自氢原子，卤素原子，氰基，硝基，C 1 -C 6烷基，C 1 -C 6卤代烷基，C 1 -C 6烷氧基和C 1 -C 6烷硫基; X 4选自氢原子，卤素原子，氰基，C 1 -C 4烷基，C 1 -C 4烷氧基和C 1 -C 4卤代烷氧基; R3是-C（R3a）（R3b）R3c，其中R3a和R3b彼此独立地是卤素原子，或者R3a和R3b与通过形成C2- C5卤代烷基链，R3c选自氢原子，卤素原子，C1-C5烷基，C1-C5卤代烷基，C1-C4卤代烷氧基和C1-C4卤代烷硫基，条件是在X1为氟原子的情况下，氯原子 或三氟甲基，X2和X3均为氢原子，X1和X2均为氟原子，X3为氢原子的情况下，X1和X2均为三氟甲基，X3为氢原子时，R3c为 氢原子，氯原子，溴原子，碘原子，C1-C5烷基，C1-C5卤代烷基，C1-C4卤代烷氧基或C1-C4卤代烷硫基。

公开(公告)号：US20140135496A1

公开(公告)日：2014-05-15

申请号：US14157048

申请日：2014-01-16

申请人： Nissan Chemical Industries, Ltd.

发明人： Takeshi MITA ,  Yuki FURUKAWA ,  Ken-ichi TOYAMA ,  Manabu YAOSAKA ,  Eitatsu IKEDA ,  Yoshihide MASUZAWA ,  Mitsuaki KOMODA

IPC分类号： C07C237/32 ,  C07D213/75 ,  C07D401/12 ,  C07D241/20 ,  C07D237/20 ,  C07D213/81 ,  C07C237/36 ,  C07D239/42

CPC分类号： C07C237/32 ,  A01N43/80 ,  C07C237/36 ,  C07D213/75 ,  C07D213/81 ,  C07D237/20 ,  C07D239/42 ,  C07D241/20 ,  C07D401/12 ,  C07D413/04

摘要： An isoxazoline-substituted benzamide compound of formula (1) or a salt thereof: wherein A1, A2 and A3 independently of one another are carbon atom or nitrogen atom, G is benzene ring, etc., W is oxygen atom or sulfur atom, etc., X is halogen atom, C1-C6haloalkyl, etc., Y ia halogen atm, C1-C6alkyl, etc., R1 is —CH═NOR1a, —C(O)OR1c, —C(O)NHR1d, phenyl substituted with (Z)p1, D-14, D-52, D-53, D-55 to D-59, etc., R1a is C1-C6alkyl, etc., R1c is C1-C6alkyl, etc., R1d is hydrogen atom, —C(O)R15, —C(O)OR15, etc., R2 is C1-C6alkyl, —CH2R14a, C1-C6alkynyl, —C(O)R15, —C(O)OR15, etc., further when R1 is —CH═NOR1a, —C(O)OR1c or —C(O)N(R1e)R1d, R2 may be hydrogen atom, R3 is C1-C6haloalkyl, etc., R14a is cyano, —OR25, etc., R15 is C1-C6alkyl, C1-C6haloalkyl, C1-C4alkoxy C1-C4alkyl, C1-C4alkylthio C1-C4alkyl, C3-C6cycloalkyl, C2-C6alkenyl, etc., R25 is C1-C4alkyl, C1-C4haloalkyl, —C(O)R32 or —C(O)OR32, etc., R32 is C1-C6alkyl or C3-C6cycloalkyl, etc., Z is halogen atom, cyano, nitro, C1-C6alkyl, C1-C6alkoxy, etc., m is an integer of 0 to 5, n is an integer of 0 to 4, p1 is an integer of 1 to 5. The pesticide containing these compounds.

摘要翻译： 式（1）的异恶唑啉取代的苯甲酰胺化合物或其盐：其中A1，A2和A3彼此独立地为碳原子或氮原子，G为苯环等，W为氧原子或硫原子等 ，X是卤素原子，C 1 -C 6卤代烷基等，卤素原子，C 1 -C 6烷基等，R 1是-CH = NOOR 1 a，-C（O）OR 1 c，-C（O）NHR 1d， （Z）p1，D-14，D-52，D-53，D-55〜D-59等，R1a为C1-C6烷基等，R1c为C1-C6烷基等，R1d为氢原子 ，-C（O）R 15，-C（O）OR 15等，R 2是C 1 -C 6烷基，-CH 2 R 14a，C 1 -C 6炔基，-C（O）R 15，-C（O）OR 15等 R1为-CH = NO1a，-C（O）OR1c或-C（O）N（R1e）R1d，R2为氢原子，R3为C1-C6卤代烷基等，R14a为氰基，-OR25等， R 15是C 1 -C 4烷基，C 1 -C 4烷基，C 1 -C 4烷基，C 1 -C 4烷氧基，C 1 -C 4烷基，C 1 -C 4烷硫基C 1 -C 4烷基，C 3 -C 6环烷基，C 2 -C 6链烯基等。 R32或-C（O）OR32等，R32是C1-C6烷基或C3-C6环烷基等，Z是卤素a 甲基，氰基，硝基，C 1 -C 6烷基，C 1 -C 6烷氧基等，m为0〜5的整数，n为0〜4的整数，p1为1〜5的整数，含有这些化合物的农药。

公开(公告)号：US20170233321A1

公开(公告)日：2017-08-17

申请号：US15586913

申请日：2017-05-04

申请人： NISSAN CHEMICAL INDUSTRIES, LTD.

发明人： Manabu YAOSAKA ,  Tomohisa UTSUNOMIYA ,  Yuji MORIYAMA ,  Tomohiro MATSUMOTO ,  Kazutaka MATOBA

IPC分类号： C07C45/72 ,  C07C51/367 ,  C07C231/12 ,  C07D413/12 ,  C07C67/343 ,  C07D249/08 ,  C07D233/60 ,  C07D401/04 ,  C07D413/14 ,  C07D213/04

CPC分类号： C07C45/72 ,  C07C45/66 ,  C07C45/74 ,  C07C49/83 ,  C07C49/835 ,  C07C51/353 ,  C07C51/367 ,  C07C51/377 ,  C07C65/40 ,  C07C67/327 ,  C07C67/343 ,  C07C67/347 ,  C07C69/65 ,  C07C231/12 ,  C07C253/30 ,  C07C319/20 ,  C07D213/30 ,  C07D213/50 ,  C07D213/61 ,  C07D233/14 ,  C07D249/08 ,  C07D261/04 ,  C07D401/04 ,  C07C323/22 ,  C07C235/84 ,  C07C255/56 ,  C07C69/76 ,  C07C49/813 ,  C07C65/38

摘要： There is provided a novel intermediate for producing pesticides. A method for producing the compound of Formula (3) comprises reacting an aromatic ketone compound of Formula (4) and a substituted acetophenone compound of Formula (5) as starting raw materials in an organic solvent or water in the presence or absence of an additive in the presence of a base in a suspended state. A method may comprise dehydrating the compound of Formula (3). A method for producing compound (2) in one step comprises reacting compound (4) and compound (5) to obtain compound (3). Further, a method for producing an isoxazoline compound of Formula (1) comprises reacting compound (2) and a hydroxylamine in an aliphatic or an aromatic hydrocarbon solvent which is optionally substituted by a halogen atom by adding an additive selected from a phase-transfer catalyst, a C1-C6 alcohol and an aprotic polar solvent in the presence of a base and water.

公开(公告)号：US20150105398A1

公开(公告)日：2015-04-16

申请号：US14568964

申请日：2014-12-12

申请人： Nissan Chemical Industries, Ltd.

发明人： Takeshi MITA ,  Takamasa KIKUCHI ,  Takashi MIZUKOSHI ,  Manabu YAOSAKA ,  Mitsuaki KOMODA

IPC分类号： C07D413/04 ,  C07D261/04

CPC分类号： A61K31/421 ,  A01N43/80 ,  A61K9/0053 ,  C07C25/02 ,  C07C25/06 ,  C07C25/08 ,  C07C25/13 ,  C07C25/24 ,  C07C43/1742 ,  C07C43/1745 ,  C07C205/11 ,  C07C205/12 ,  C07C211/52 ,  C07C251/48 ,  C07C255/29 ,  C07C255/50 ,  C07C255/60 ,  C07C281/02 ,  C07C323/09 ,  C07D261/04 ,  C07D261/16 ,  C07D413/04 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/06 ,  C07D417/12 ,  C07F7/0812

摘要： A substituted alkenylbenzene compound of formula (4): wherein X1 is selected from the group consisting of a halogen atom, —SF5, C1-C6haloalkyl, hydroxy C1-C6haloalkyl, C1-C6alkoxy C1-C6haloalkyl, C3-C8halocycloalkyl, C1-C6 haloalkoxy C1-C3haloalkoxy C1-C3haloalkoxy, C1-C6haloalkylthio, C1-C6haloalkylsulfinyl and C1-C6haloalkylsulfonyl; X3 is selected from the group consisting of a hydrogen atom, halogen atom, cyano, nitro, C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy and C1-C6 alkylthio; X4 is selected from the group consisting of a hydrogen atom, halogen atom, cyano, C1-C4alkyl, C1-C4alkoxy and C1-C4haloalkoxy; R3 is —C(R3a)(R3b)R3c, where R3a and R3b independently of each other are a halogen atom, or R3a and R3b together form 3- to 6-membered ring together with the carbon atom bonding them by forming a C2-C5haloalkylene chain, and R3c is selected from the group consisting of a hydrogen atom, halogen atom, C1-C5alkyl, C1-C5haloalkyl, C1-C4haloalkoxy and C1-C4haloalkylthio, with a proviso that in case here X1 is a fluorine atom, chlorine atom or trifluoromethyl, and both X2 and X3 are a hydrogen atom, in case where both X1 and X2 are fluorine atom and X3 is a hydrogen atom, and in case where both X1 and X2 are trifluoromethyl and X3 is a hydrogen atom, R3c is a hydrogen atom, chlorine atom, bromine atom, iodine atom, C1-C5alkyl, C1-C5haloalkyl, C1-C4haloalkoxy or C1-C4haloalkylthio.

摘要翻译： 式（4）的取代烯基苯化合物：其中X 1选自卤素原子，-SF 5，C 1 -C 6卤代烷基，羟基C 1 -C 6卤代烷基，C 1 -C 6烷氧基C 1 -C 6卤代烷基，C 3 -C 8卤代环烷基，C 1 -C 6卤代烷氧基 C 1 -C 3卤代烷氧基C 1 -C 3卤代烷氧基，C 1 -C 6卤代烷硫基，C 1 -C 6卤代烷基亚磺酰基和C 1 -C 6卤代烷基磺酰基; X 3选自氢原子，卤素原子，氰基，硝基，C 1 -C 6烷基，C 1 -C 6卤代烷基，C 1 -C 6烷氧基和C 1 -C 6烷硫基; X 4选自氢原子，卤素原子，氰基，C 1 -C 4烷基，C 1 -C 4烷氧基和C 1 -C 4卤代烷氧基; R3是-C（R3a）（R3b）R3c，其中R3a和R3b彼此独立地是卤素原子，或者R3a和R3b与通过形成C2- C5卤代烷基链，R3c选自氢原子，卤素原子，C1-C5烷基，C1-C5卤代烷基，C1-C4卤代烷氧基和C1-C4卤代烷硫基，条件是在这里X1是氟原子的情况下，氯原子 或三氟甲基，X2和X3均为氢原子，X1和X2均为氟原子，X3为氢原子的情况下，X1和X2均为三氟甲基，X3为氢原子时，R3c为 氢原子，氯原子，溴原子，碘原子，C1-C5烷基，C1-C5卤代烷基，C1-C4卤代烷氧基或C1-C4卤代烷硫基。