Invention Application
- Patent Title: MUTATED IMMUNOGLOBULIN-BINDING POLYPEPTIDES
- Patent Title (中): 突变型免疫抑制蛋白结合多肽
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Application No.: US14903837Application Date: 2014-07-08
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Publication No.: US20160159855A1Publication Date: 2016-06-09
- Inventor: Gustav Rodrigo , Mats Ander , Tomas BJORKMAN , Goran Bauren
- Applicant: GE HEALTHCARE BIO-SCIENCES AB
- Priority: SE1350859-3 20130710; SE1350860-1 20130710
- International Application: PCT/SE2014/050872 WO 20140708
- Main IPC: C07K1/22
- IPC: C07K1/22 ; C07K14/745 ; C07K16/00 ; C07K14/31
Abstract:
A polypeptide with improved alkaline stability, which polypeptide comprises a mutant of a B or C domain of Staphylococcus Protein A, as specified by SEQ ID NO 1 or SEQ ID NO 2, or of Protein Z, as specified by SEQ ID NO 3, wherein at least the glutamine residue at position 9 has been mutated to an amino acid other than asparagine. The invention also discloses multimers of said polypeptide, as well as separation matrices comprising the multimers or polypeptides.
Public/Granted literature
- US09896486B2 Mutated immunoglobulin-binding polypeptides Public/Granted day:2018-02-20
Information query
