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    Mutated Immunoglobulin-Binding Polypeptides
    2.
    发明申请
    Mutated Immunoglobulin-Binding Polypeptides 审中-公开
    突变的免疫球蛋白结合多肽

    公开(公告)号：US20160159857A1

    公开(公告)日：2016-06-09

    申请号：US14961164

    申请日：2015-12-07

    Applicant: GE Healthcare Bio-Sciences AB

    Inventor： Gustav Rodrigo ,  Mats Ander ,  Göran Baurén ,  Tomas Björkman

    IPC: C07K1/22 ,  C07K16/00 ,  C07K14/31

    CPC classification number: C07K14/31 ,  B01D15/3809 ,  B01J20/286 ,  B01J20/3204 ,  B01J20/3212 ,  B01J20/3219 ,  B01J20/3274 ,  C07K1/22 ,  C07K14/745 ,  C07K16/00

    Abstract: The invention discloses a polypeptide with improved alkaline stability, which polypeptide comprises a mutant of a B or C domain of Staphylococcus Protein A (SpA), as specified by SEQ ID NO 1 or SEQ ID NO 2, or of Protein Z, as specified by SEQ ID NO 3, comprising at least the mutation wherein the glutamine residue at position 9 has been mutated to a tryptophan, leucine, glutamic acid, valine or lysine. The invention also discloses multimers of the polypeptide, as well as separation matrices comprising the multimers or polypeptides.

    Abstract translation: 本发明公开了一种具有改善的碱稳定性的多肽，该多肽包含如SEQ ID NO：1或SEQ ID NO：2或蛋白Z所定义的葡萄球菌蛋白A（SpA）的B或C结构域的突变体，如 SEQ ID NO 3至少包含其中位置9处的谷氨酰胺残基突变为色氨酸，亮氨酸，谷氨酸，缬氨酸或赖氨酸的突变。 本发明还公开了多肽的多聚体，以及包含多聚体或多肽的分离基质。

    AFFINITY CHROMATOGRAPHY MATRIX
    4.
    发明申请
    AFFINITY CHROMATOGRAPHY MATRIX 审中-公开
    亲属色谱矩阵

    公开(公告)号：US20150080554A1

    公开(公告)日：2015-03-19

    申请号：US14385336

    申请日：2013-03-26

    Applicant: GE HEALTHCARE BIO-SCIENCES AB

    Inventor： Mats Ander ,  Goran Bauren ,  Tomas Bjorkman ,  Per-Mikael Aberg ,  Gustav Rodrigo

    IPC: C07K16/00 ,  C07K14/31 ,  G01N33/68 ,  B01J20/291

    CPC classification number: C07K16/00 ,  B01D15/3809 ,  B01J20/286 ,  B01J20/291 ,  B01J20/3212 ,  B01J20/3219 ,  B01J20/3274 ,  B01J2220/80 ,  C07K1/22 ,  C07K14/31 ,  G01N33/6854

    Abstract: The invention discloses an immunoglobulin-binding protein comprising one or more mutated immunoglobulin-binding domains (monomers) of staphylococcal Protein A (E, D, A, B, C) or protein Z or a functional variant thereof, wherein in at least one of the one or more mutated monomers, the asparagine or histidine at the position corresponding to H18 of the B domain of Protein A or of Protein Z has been deleted or substituted with a first amino acid residue which is not proline or asparagine and wherein, if the amino acid residue at position 57 is proline and the amino acid residue at position 28 is asparagine, then the amino acid residue at the position corresponding to H18 of the B domain of protein A or of protein Z is not serine, threonine or lysine.

    Abstract translation: 本发明公开了一种免疫球蛋白结合蛋白，其包含葡萄球菌蛋白A（E，D，A，B，C）或蛋白Z或其功能变体的一个或多个突变的免疫球蛋白结合结构域（单体），其中至少一个 一个或多个突变单体，在对应于蛋白A或蛋白Z的B结构域的H18的位置处的天冬酰胺或组氨酸已被缺失或被不是脯氨酸或天冬酰胺的第一氨基酸残基取代，并且其中，如果 第57位的氨基酸残基是脯氨酸，28位的氨基酸残基是天冬酰胺，则相应于蛋白A的B结构域或蛋白Z的H18位置的氨基酸残基不是丝氨酸，苏氨酸或赖氨酸。

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