A system and a method select a datapath through a meshed Input/Output (IO) fabric. A plurality of port controllers is coupled to interconnection logic. Each port controller is coupled to a corresponding communication link and outputs a detection signal if the corresponding communication link transitions from a first lower-power state to a second higher power state. The interconnection logic, responsive to the detection signal, is configured to output a first signal to one or more selected port controllers to transition the corresponding communication link coupled to the selected port controller from the first power state to the second power state based on a frequency of use of a datapath between the communication link corresponding to the port controller outputting the detection signal and the communication link corresponding to each of the one or more selected port controllers.