Methods and apparatus for managing connections be multiple internal integrated circuits (ICs) of for example, a high-speed internal device interface. Improved schemes for coordination of connection and disconnection events, and/or suspension and resumption of operation for a High-Speed Inter. Chip™ (HSIC) in are disclosed. In one exemplary embodiment, a “device”-initiated and “host”-initiated connect/disconnect procedure is disclosed, that provides improved dining, synchronization, and power consumption.