Invention Application
- Patent Title: MACROCYCLIC BENZODIAZEPINE DIMERS, CONJUGATES THEREOF, PREPARATION AND USES
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Application No.: US15606512Application Date: 2017-05-26
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Publication No.: US20170260205A1Publication Date: 2017-09-14
- Inventor: Yong ZHANG , Robert M. BORZILLERI , Andrew J. TEBBEN , Erik STANG , Andrew F. DONNELL , Gretchen M. SCHROEDER , Heidi L. PEREZ , Donna D. WEI
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Main IPC: C07D498/22
- IPC: C07D498/22 ; A61K31/5517 ; A61K31/5513 ; C07K16/30 ; C07D519/00
Abstract:
Macrocyclic benzodiazepine dimers having a structure represented by formula I where A and B are independently according to formulae Ia or Ib and the other variables in formulae I, Ia, and Ib are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used as the drug component in an antibody-drug conjugate (ADC).
Public/Granted literature
- US09902740B2 Macrocyclic benzodiazepine dimers, conjugates thereof, preparation and uses Public/Granted day:2018-02-27
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