公开(公告)号：US20170260205A1

公开(公告)日：2017-09-14

申请号：US15606512

申请日：2017-05-26

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Yong ZHANG ,  Robert M. BORZILLERI ,  Andrew J. TEBBEN ,  Erik STANG ,  Andrew F. DONNELL ,  Gretchen M. SCHROEDER ,  Heidi L. PEREZ ,  Donna D. WEI

IPC: C07D498/22 ,  A61K31/5517 ,  A61K31/5513 ,  C07K16/30 ,  C07D519/00

CPC classification number: C07D498/22 ,  A61K31/5513 ,  A61K31/5517 ,  A61K47/48384 ,  A61K47/48569 ,  A61K47/48592 ,  A61K47/48615 ,  A61K47/48638 ,  A61K47/48715 ,  A61K47/6801 ,  A61K47/6803 ,  A61K47/6851 ,  A61K47/6857 ,  A61K47/6859 ,  A61K47/6863 ,  A61K47/6869 ,  A61K47/6889 ,  C07D519/00 ,  C07K16/30 ,  C07K16/3023 ,  C07K16/3046 ,  C07K16/3069

Abstract: Macrocyclic benzodiazepine dimers having a structure represented by formula I where A and B are independently according to formulae Ia or Ib and the other variables in formulae I, Ia, and Ib are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used as the drug component in an antibody-drug conjugate (ADC).