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公开(公告)号：US20170260205A1
公开(公告)日：2017-09-14
申请号：US15606512
申请日：2017-05-26
发明人： Yong ZHANG , Robert M. BORZILLERI , Andrew J. TEBBEN , Erik STANG , Andrew F. DONNELL , Gretchen M. SCHROEDER , Heidi L. PEREZ , Donna D. WEI
IPC分类号： C07D498/22 , A61K31/5517 , A61K31/5513 , C07K16/30 , C07D519/00
CPC分类号： C07D498/22 , A61K31/5513 , A61K31/5517 , A61K47/48384 , A61K47/48569 , A61K47/48592 , A61K47/48615 , A61K47/48638 , A61K47/48715 , A61K47/6801 , A61K47/6803 , A61K47/6851 , A61K47/6857 , A61K47/6859 , A61K47/6863 , A61K47/6869 , A61K47/6889 , C07D519/00 , C07K16/30 , C07K16/3023 , C07K16/3046 , C07K16/3069
摘要： Macrocyclic benzodiazepine dimers having a structure represented by formula I where A and B are independently according to formulae Ia or Ib and the other variables in formulae I, Ia, and Ib are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used as the drug component in an antibody-drug conjugate (ADC).
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2.发明申请公开(公告)号：US20160376288A1
公开(公告)日：2016-12-29
申请号：US15189388
申请日：2016-06-22
发明人： Yong ZHANG , Robert M. BORZILLERI , Andrew J. TEBBEN , Erik M. STANG , Andrew F. DONNELL , Gretchen M. SCHROEDER , Heidi L. PEREZ , Donna D. WEI
IPC分类号： C07D498/22 , C07K16/30 , A61K47/48
CPC分类号： C07D498/22 , A61K31/5513 , A61K31/5517 , A61K47/48384 , A61K47/48569 , A61K47/48592 , A61K47/48615 , A61K47/48638 , A61K47/48715 , A61K47/6801 , A61K47/6803 , A61K47/6851 , A61K47/6857 , A61K47/6859 , A61K47/6863 , A61K47/6869 , A61K47/6889 , C07D519/00 , C07K16/30 , C07K16/3023 , C07K16/3046 , C07K16/3069
摘要： Macrocyclic benzodiazepine dimers having a structure represented by formula I where A and B are independently according to formulae Ia or Ib and the other variables in formulae I, Ia, and Ib are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used as the drug component in an antibody-drug conjugate (ADC).
摘要翻译： 并且式I，Ia和Ib中的其它变量如本申请中所定义。 这种二聚体可用作抗癌剂，特别是用作抗体 - 药物偶联物（ADC）中的药物成分时。
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