公开(公告)号：US20230144824A1

公开(公告)日：2023-05-11

申请号：US17793248

申请日：2021-01-26

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Liqi HE ,  Ashvinikumar V. GAVAI ,  Sanjeev GANGWAR ,  Qiang CONG ,  Yam B. POUDEL ,  Prasanna SIVAPRAKASAM ,  Christine M. TARBY ,  Patrice GILL ,  Andrew F. DONNELL ,  Murugaiah ANDAPPAN MURUGAIAH SUBBAIAH

IPC: C07D487/04

CPC classification number: C07D487/04

Abstract: Compounds according to formula I or II are useful as agonists of Toll-like receptor 7 (TLR7). Such compounds can be used in cancer treatment, especially in combination with an anti-cancer immunotherapy agent, or as a vaccine adjuvant.

公开(公告)号：US20170260205A1

公开(公告)日：2017-09-14

申请号：US15606512

申请日：2017-05-26

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Yong ZHANG ,  Robert M. BORZILLERI ,  Andrew J. TEBBEN ,  Erik STANG ,  Andrew F. DONNELL ,  Gretchen M. SCHROEDER ,  Heidi L. PEREZ ,  Donna D. WEI

IPC: C07D498/22 ,  A61K31/5517 ,  A61K31/5513 ,  C07K16/30 ,  C07D519/00

CPC classification number: C07D498/22 ,  A61K31/5513 ,  A61K31/5517 ,  A61K47/48384 ,  A61K47/48569 ,  A61K47/48592 ,  A61K47/48615 ,  A61K47/48638 ,  A61K47/48715 ,  A61K47/6801 ,  A61K47/6803 ,  A61K47/6851 ,  A61K47/6857 ,  A61K47/6859 ,  A61K47/6863 ,  A61K47/6869 ,  A61K47/6889 ,  C07D519/00 ,  C07K16/30 ,  C07K16/3023 ,  C07K16/3046 ,  C07K16/3069

Abstract: Macrocyclic benzodiazepine dimers having a structure represented by formula I where A and B are independently according to formulae Ia or Ib and the other variables in formulae I, Ia, and Ib are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used as the drug component in an antibody-drug conjugate (ADC).

公开(公告)号：US20230118688A1

公开(公告)日：2023-04-20

申请号：US17792869

申请日：2021-01-26

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Heng CHENG ,  Christine M. TARBY ,  Sanjeev GANGWAR ,  Ashvinikumar V. GAVAI ,  Walter L. JOHNSON ,  Yam B. POUDEL ,  Prasanna SIVAPRAKASAM ,  Patrice GILL ,  Andrew F. DONNELL ,  Murugaiah Andappan Murugaiah SUBBAIAH

IPC: A61K31/519 ,  C07D487/04 ,  A61K39/395

Abstract: Compounds according to formula I are useful as agonists of Toll-like receptor 7 (TLR7). Such compounds can be used in cancer treatment, especially in combination with an anti-cancer immunotherapy agent, or as a vaccine adjuvant.

公开(公告)号：US20160376288A1

公开(公告)日：2016-12-29

申请号：US15189388

申请日：2016-06-22

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Yong ZHANG ,  Robert M. BORZILLERI ,  Andrew J. TEBBEN ,  Erik M. STANG ,  Andrew F. DONNELL ,  Gretchen M. SCHROEDER ,  Heidi L. PEREZ ,  Donna D. WEI

IPC: C07D498/22 ,  C07K16/30 ,  A61K47/48

CPC classification number: C07D498/22 ,  A61K31/5513 ,  A61K31/5517 ,  A61K47/48384 ,  A61K47/48569 ,  A61K47/48592 ,  A61K47/48615 ,  A61K47/48638 ,  A61K47/48715 ,  A61K47/6801 ,  A61K47/6803 ,  A61K47/6851 ,  A61K47/6857 ,  A61K47/6859 ,  A61K47/6863 ,  A61K47/6869 ,  A61K47/6889 ,  C07D519/00 ,  C07K16/30 ,  C07K16/3023 ,  C07K16/3046 ,  C07K16/3069

Abstract: Macrocyclic benzodiazepine dimers having a structure represented by formula I where A and B are independently according to formulae Ia or Ib and the other variables in formulae I, Ia, and Ib are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used as the drug component in an antibody-drug conjugate (ADC).

Abstract translation: 并且式I，Ia和Ib中的其它变量如本申请中所定义。 这种二聚体可用作抗癌剂，特别是用作抗体 - 药物偶联物（ADC）中的药物成分时。