Methods and apparatus for managing connections between multiple internal integrated circuits (ICs) of, for example, a high-speed internal device interface. Improved schemes for coordination of connection and disconnection events, and/or suspension and resumption of operation for a High-Speed Inter-Chip™ (HSIC) interface are disclosed. In one exemplary embodiment, a “device”-initiated and “host”-initiated connect/disconnect procedure is disclosed, that provides improved timing, synchronization, and power consumption.