- 专利标题: METHODS AND DEVICES TO DETECT THE PRESENCE OF A CONDITION ASSOCIATED WITH ATP DEPLETION IN A SUBJECT
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申请号: US15580582申请日: 2016-06-03
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公开(公告)号: US20180155754A1公开(公告)日: 2018-06-07
- 发明人: Nicholas Dale , Chris Imray , Bruno Frenguelli
- 申请人: Sarissa Biomedical Limited
- 优先权: GB1509974.0 20150609
- 国际申请: PCT/GB2016/051641 WO 20160603
- 主分类号: C12Q1/00
- IPC分类号: C12Q1/00 ; C12Q1/26 ; C12Q1/48 ; C12Q1/34 ; G01N27/327
摘要:
The invention provides a method of determining a predisposition to a condition associated with ATP depletion, such as an ischaemic event, in a subject comprising: a. measuring the concentration of one or more purines in a body fluid of the subject, the purines being selected from adenosine, inosine, hypoxanthine, xanthine and ATP, and b. comparing the measured concentration with a threshold concentration of the one or more purines, wherein the threshold concentration is preferably in the range 2 [micro]M to 8 [micro]M and wherein a measured concentration higher than the threshold concentration indicates the presence of ischaemia.
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