Invention Application
- Patent Title: Systems and Methods for Detection of Aneuploidy
-
Application No.: US15887914Application Date: 2018-02-02
-
Publication No.: US20180173846A1Publication Date: 2018-06-21
- Inventor: Styrmir SIGURJONSSON , Naresh VANKAYALAPATI , Allison RYAN , Zachary DEMKO , Milena BANJEVIC
- Applicant: Natera, Inc.
- Applicant Address: US CA San Carlos
- Assignee: Natera, Inc.
- Current Assignee: Natera, Inc.
- Current Assignee Address: US CA San Carlos
- Main IPC: G06F19/22
- IPC: G06F19/22 ; G06F19/12

Abstract:
Provided herein are improved methods for detecting aneuploidy in a sample. The methods in certain embodiments are used for the analysis of circulating DNA in serum samples, such as circulating fetal DNA or circulating tumor DNA. In certain embodiments, chromosome or chromosome segments of interest are used to set a bias model and/or a control value for a z-score determination, in illustrative examples without the use of a control chromosome.
Information query